Human leucocyte antigen determinants of susceptibility to Barrett's oesophagus in Asians – a preliminary study

Rajendra, Shanmugarajah; Ackroyd, Roger; Murad, Shahnaz; Mohan, Chandra; Ho, Jacqueline J; Goh, Kazutomo; Azrena, A.; Too, Chun-Lai

doi:10.1111/j.1365-2036.2005.02496.x

Cited by 25 publications

(26 citation statements)

References 39 publications

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“…This allele is important in the immunological control of HPV16 infection and is the most commonly found HLA-B specificity in American Caucasians, European Caucasians and Indians. The HLA-B7 allele has also been associated with Barrett’s oesophagus in one study 49. However, given the small number of patients studied, these results are only preliminary.…”

Section: Evidence For An Analogous Association Between Human Papillommentioning

confidence: 92%

Similar immunogenetics of Barrett’s oesophagus and cervical neoplasia: is HPV the common denominator?

Rajendra

Robertson²

2009

J Clin Pathol

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There are a number of similarities between cervical cancer and oesophageal adenocarcinoma. As cervical cancer is overwhelmingly associated with oncogenic human papillomavirus (HPV) infection, the possibility that HPV is also associated with the aetiology of oesophageal adenocarcinoma needs to be examined. This paper presents the evidence for such an association and a discussion of what further studies would be needed to confirm such an association. EVIDENCE FOR AN ANALOGOUS ASSOCIATION BETWEEN HUMAN PAPILLOMAVIRUS (HPV) AND CERVICAL CANCER AND OESOPHAGEAL ADENOCARCINOMAHPV has been identified as the major aetiological factor in cervical carcinogenesis, 1 being detected in 90-100% of cervical cancer specimens compared with 20% of controls. 2 In addition, the HPV viral genome has been identified in most of the precursor lesions of cervical intraepithelial neoplasia. 3 HPVs are epitheliotropic and were thought to preferentially infect squamous epithelia only. However, it is now known that much of the virus is present at the squamocolumnar junction. Moreover, a consistent, strong and robust association between infection by high-risk HPV types and risk of development of adenocarcinoma of the cervix has been demonstrated. 4 5The role of HPV-mediated tumorigenesis in cervical cancer raises the question of the possible pathogenic role of the virus in oesophageal squamous and adenocarcinoma, oropharyngeal cancers and other non-genital malignancies. The recent demonstration of an association between HPV infection and oropharyngeal cancers, and the demonstration that this association may be related to direct or indirect orogenital transmission, reveals the exposure of the upper gastrointestinal tract to HPV infection. 6 There is some evidence for a plausible role for HPV in the pathogenesis of squamous cell carcinoma of the oesophagus. 7 High-risk-type HPV infections (predominantly HPV16 and HPV18) are detected in about 15% and 23% of patients with oesophageal squamous carcinoma using PCR and in situ hybridisation techniques, respectively. 7 HPV detection rates in oesophageal cancer are highly variable in different geographical areas of the world and are significantly higher in high-risk areas than in low-risk regions. 7 Oesophageal squamous papillomas are believed to arise from a multistep process involving HPV and chronic reflux. 8

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Section: Evidence For An Analogous Association Between Human Papillommentioning

confidence: 92%

Similar immunogenetics of Barrett’s oesophagus and cervical neoplasia: is HPV the common denominator?

Rajendra

Robertson²

2009

J Clin Pathol

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“…5 Host cytotoxic (cytotoxic T lymphocyte) cells and helper T cells can potentially recognise these neo-antigens presented by human leucocyte antigen (HLA) class I or II molecules, respectively. 6 We recently reported that HLA B7 may be a susceptibility locus for Barrett's oesophagus, 7 although the precise mechanism of association remains elusive. HLA molecules perform a crucial function in the regulation of the immune response.…”

mentioning

confidence: 99%

Loss of human leucocyte antigen class I and gain of class II expression are early events in carcinogenesis: clues from a study of Barrett’s oesophagus

et al. 2006

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“…HLA class II antigens appear in pathological circumstances, like in inflammation, infection, tumour transformation and autoimmunity (20) . Other study demonstrated the association between Barrett's esophagus in Asians, particularly Indians, with HLA-B7; reinforcing a genetic component to gastroesophageal reflux disease (18) . The prevalence of GERD is differed in different ethnic countries across the world, there is a higher prevalence rates in Western countries compared with the Far East.…”

Section: Discussionmentioning

confidence: 84%

“…Other genetic factor is Human Leukocyte Antigen (HLA) system, which has an extensive polymorphism and considered as an excellent marker for population genetic analyses and disease association. Rajendra et al (18) found that inheritance of the HLA-B*07 gene confers an increased risk for Barrett's esophagus in south Asians (mostly south Indians) but not Orientals (Malays and Chinese). They also showed that HLA-B*07 positive patients with Barrett's esophagus had a significantly higher family history of GERD symptoms, compared with their HLA-B*07 negative counterparts.…”

Section: Introductionmentioning

confidence: 99%

Human leukocyte antigen HLADRB1 determinants susceptibility to gastroesophageal reflux disease

Mahdi

Hasan

Salih

2017

Arq. Gastroenterol.

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-Background -Gastroesophageal reflux disease (GERD) is characterized by diverse symptoms. There is an evidence for a genetic component to GERD as supported by familial aggregation of this disease. Objective -To investigate whether certain human leucocyte antigen genes HLA-DRB1 are associated with GERD. Methods -Patients and controls were prospectively recruited from GIT center at Al-Kindy Teaching Hospital (Baghdad-Iraq)

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Human leucocyte antigen determinants of susceptibility to Barrett's oesophagus in Asians – a preliminary study

Cited by 25 publications

References 39 publications

Similar immunogenetics of Barrett’s oesophagus and cervical neoplasia: is HPV the common denominator?

Similar immunogenetics of Barrett’s oesophagus and cervical neoplasia: is HPV the common denominator?

Loss of human leucocyte antigen class I and gain of class II expression are early events in carcinogenesis: clues from a study of Barrett’s oesophagus

Human leukocyte antigen HLADRB1 determinants susceptibility to gastroesophageal reflux disease

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