Human leucocyte antigen-G polymorphisms are associated with cervical squamous cell carcinoma risk in Taiwanese women

HLA‐G 3′ untranslated region polymorphic sites associated with increased HLA‐G production are more frequent in patients exhibiting differentiated thyroid tumours

“…The present study showed higher frequency of G allele and of the +3142GG genotype in colloidal goitre and a higher frequency of the heterozygous +3142CG genotype in thyroid cancer, and these genotypes have been associated with decreased and increased sHLA‐G expression, respectively . In other types of cancer, the +3142CC genotype and C allele are associated with susceptibility to cervical squamous cell carcinoma …”

“…32 In other types of cancer, the +3142CC genotype and C allele are associated with susceptibility to cervical squamous cell carcinoma. 33 The presence of an Adenine at position +3187 modifies an AUrich motif in HLA-G mRNA, decreasing its stability and consequently HLA-G production. 14,34 Individuals exhibiting the +3187AA genotype presented decreased sHLA-G production compared to +3187GG and +3187AG genotypes.…”

Human leucocyte antigen‐G 14‐bp InDel polymorphism and oral squamous cell carcinoma risk in Chinese Han population: A case–control study

“…Mounting evidence indicates that HLA‐G is involved in the development and progression of human cancers, and numerous studies have been conducted to explore the potential relationship of HLA‐G 14‐bp InDel polymorphism with cancer risk, such as breast cancer (Jeong et al, ), colorectal cancer (Garziera et al, ) and cervical squamous cell carcinoma (Yang et al, ). A meta‐analysis by Li et al () showed that HLA‐G 14‐bp InDel polymorphism contributes to breast cancer susceptibility, but is not associated with the overall cancer risk.…”

Familial clustering of oropharyngeal squamous cell carcinoma in the Utah population

“…Prolonged infection has been linked with a higher risk of developing HPV‐associated malignant processes, suggesting that immune‐mediated clearance of HPV infection underlies, at least in part, the development of HPV malignancies. Supporting this are findings from multiple studies linking polymorphisms in immune mediators to an increased risk of cervical cancer . For HPV‐associated oropharyngeal cancer, polymorphisms in immune mediators, such as transforming growth factor‐beta1 and tumor necrosis factor‐alpha, as well as pathways critical to genome integrity and programmed cell death, such as p53 and p73, are linked to an increased risk of oropharyngeal cancer …”

“…Supporting this are findings from multiple studies linking polymorphisms in immune mediators to an increased risk of cervical cancer. [14][15][16][17][18][19] For HPV-associated oropharyngeal cancer, polymorphisms in immune mediators, such as transforming growth factor-beta1 and tumor necrosis factoralpha, as well as pathways critical to genome integrity and programmed cell death, such as p53 and p73, are linked to an increased risk of oropharyngeal cancer. [20][21][22][23][24][25][26] Given elevated rates of both oropharyngeal as well as cervical cancer in relatives of patients with oropharyngeal SCC, education regarding the relationship between HPV and cancer should be offered to the patient and extended to their family members.…”