Human leucocyte antigen risk alleles for psoriatic arthritis among patients with psoriasis

Abstract

Certain HLA-B and HLA-C alleles confer susceptibility to PsA among patients with psoriasis and may be used to identify patients with PsC who may develop PsA.

Predictors for clinical outcome in psoriatic arthritis – what have we learned from cohort studies?

“…HLA-C*06 is the strongest genetic risk factor for psoriasis and also predisposes to earlier onset and more severe disease [53,54]. HLA-B alleles are associated with musculoskeletal manifestations and HLA-B*27, *B38, B*39 and B*08 were reported as specific genetic markers for PsA among patients with psoriasis, while HLA-C*06 has been associated with lower risk of developing PsA [55]. They reported that HLA-C*06 and DR*07 were associated with fewer damaged and involved joints (OR 0.59 for the presence of both alleles).…”

Genetic, Epigenetic and Pharmacogenetic Aspects of Psoriasis and Psoriatic Arthritis

“…6,8 A recent large fine-mapping study of psoriatic disease within the MHC region using an HLA-variant imputation approach, has shed new light regarding HLA associations within this region for PsV and PsA. 9 In this elegant study, Okada and colleagues 9 defined the 4-digit HLA allele and amino acid resolutions.…”

Management of patients with psoriatic arthritis

“…The highest positive predictive value is noted with HLA-B27, which is present in up to 50% of patients with psoriatic arthritis. 6 Histologically, synovial infl ammation in psoriatic arthritis has many similarities to rheumatoid arthritis. Both feature increased levels of activated T cells and infl ammatory cytokines and mediators, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-17, IL-23, and other cytokines.…”