Human Leukocyte Antigen-G, a New Parameter in the Follow-up of Liver Transplantation

Baştürk, Bilkay; Karakayalı, Feza; Emiroğlu, R; Sozer, Oktay; Haberal, A; Bal, Dominika; Haberal, Mehmet

doi:10.1016/j.transproceed.2005.12.108

Cited by 41 publications

(25 citation statements)

References 17 publications

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“…Studies carried out in transplant recipients have made the following observations: i) in renal allograft recipients, the presence of serum sHLA-G is positively correlated with functioning transplants [52], ii) heart transplanted patients displaying a significant increase in serum sHLA-G in the first month after transplantation have a lower incidence of severe rejection episodes than patients with low levels of the molecule [53], and iii) in liver transplanted patients, high serum levels of sHLA-G showed a positive correlation with normal liver function tests, whereas a fall in sHLA-G levels was rapidly followed by deterioration of liver functional parameters [25,54].…”

Section: Ii) Transplantationmentioning

confidence: 97%

Soluble HLA-G: Are they clinically relevant?

Pistoia¹,

Morandi²,

Wang³

et al. 2007

Seminars in Cancer Biology

162

182

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HLA-G is a non-classical HLA-class Ib molecule with multiple immunoregulatory properties. Its main function in physiological conditions is to abrogate maternal NK cell activity against foetal tissue and to establish immune tolerance at maternal-foetal interface. HLA-G is expressed not only as a membrane bound molecule on the surface of cells, but also as a soluble moiety in body fluids. The major isoforms of HLA-G present in serum are soluble HLA-G1 and HLA-G5 which are generated by shedding or proteolytic cleavage of the membrane bound isoform and by secretion of a soluble isoform, respectively.Here we review the data about soluble HLA-G (sHLA-G) serum levels in different pathological conditions, including immune-mediated disorders, transplantation, and malignancies. In particular, we focus on sHLA-G expression and function in human neuroblastoma, a pediatric tumor, with special emphasis on a novel potential immuno escape mechanism utilized by NB to instruct monocytes to produce and release sHLA-G. Finally, the potential clinical relevance of sHLA-G serum levels is discussed.

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Section: Ii) Transplantationmentioning

confidence: 97%

Soluble HLA-G: Are they clinically relevant?

Pistoia¹,

Morandi²,

Wang³

et al. 2007

Seminars in Cancer Biology

162

182

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“…The HLA polymorphism can also be involved. It was shown recently that soluble HLA-G was associated to immunological heart and liver tolerance [34][35][36].…”

Section: Ctla-4-mediated Tolerant T-cell Phenotype In Ltrmentioning

confidence: 99%

CTLA-4-mediated regulatory phenotype of T-cells in tolerant lung recipients

Botturi¹,

Lacoeuille²,

Thomas³

et al. 2008

Eur Respir J

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Obliterative bronchiolitis (OB) is the major cause of long-term lung allograft loss resulting from an unclear immune process occurring in the absence of the donor's immune cells. The present authors hypothesised that interactions of autologous dendritic cells (DCs) with Tcells could differ in OB patients compared with healthy lung transplant recipients (LTRs).Monocyte-derived DCs from 14 OB and 35 non-OB LTRs were cultured with autologous T-cells. T-regulatory (Treg) cells, co-receptors, cytokine production, DC phenotype and indoleamine 2,3-dioxygenase (IDO) expression were assessed by flow cytometry. Experiments were repeated in the presence of Pseudomonas aeruginosa or anti-co-receptor antibodies.DCs from non-OB LTR upregulated Treg cells, cytotoxic T-lymphocyte antigen (CTLA)-4 and interleukin (IL)-10. By contrast CD28 and inducible T-cell co-stimulator were downregulated concomitantly to IL-13 and IL-4. Compared to OB, non-OB DCs displayed an immature phenotype with lower CD80 and CD83 and higher IDO levels of expression. Stimulation by P. aeruginosa did not abolish the tolerogenic effects of DCs on non-OB T-cells. Finally, decreased Treg cells and IL-10 production were detected when adding anti-CTLA-4 antibodies in non-OB LTR.The present study demonstrates that dendritic cells from nonobliterative bronchiolitis lung transplant recipients induce a tolerant T-cell phenotype which is dependent on cytotoxic T-lymphocyte antigen-4 engagement.

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“…1 It was discovered in trophoblastic tissue, 2 and is expressed at high levels by this tissue. 3 The nonclassical HLA-G molecule is distinguished from classical HLA-class 1 by different features and properties, among them is its restricted tissue distribution and its biological properties leading to immune tolerance.…”

Section: Introductionmentioning

confidence: 99%

“…Besides treatment, the genetic background of donor and recipient and the presence of inflammatory mediators present in the graft milieu also may be responsible for HLA-G modulation. 1,12,13,15 The significance of sHLA-G in immunotolerance is a subject of ongoing research. 16 …”

Section: Introductionmentioning

confidence: 99%

Untitled

2015

Exp Clin Transplant

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Objectives: Studying immune tolerance induced by HLA-G in kidney allograft acceptance may help understanding of its mechanisms, hoping in the future to boaster it and decrease the immunosuppressive drugs given that are well known to have serious adverse effects. Materials and Methods: The current study sought to evaluate soluble HLA-G in 3 groups: kidney transplanted patients with no rejection episodes, transplanted patients with biopsy-proven renal rejection, and healthy age-matched non transplanted individuals.Three groups were studied: kidney transplanted patients with no rejection episodes (n = 43); transplanted patients with biopsy-proven renal rejection (n = 27); healthy, age-matched, nontransplanted individuals as controls (n = 42). Soluble HLA-G level was measured in the serum by a quantitative sandwich enzyme linked immunosorbent assay. Results: sHLAG level was significantly higher in the transplanted patients compared with the control. Prograf and not cyclosporine or Rapamune had positive effects on sHLAG levels. Patients with chronic rejection had a significant lower level of sHLAG compared with a graft stable group. No effect of donor type, infection or duration posttransplant, on sHLAG levels was found. Conclusions:The results of the current study are consistent with previous studies addressing the role of sHLAG in inducing immunotolerance postkidney transplant. The findings from the current study on the chronic rejection group, supports the on-going research of having a treatment with HLA-G/or derivate, which may constitute in the future a novel efficient anti-graft rejection therapy.

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Human Leukocyte Antigen-G, a New Parameter in the Follow-up of Liver Transplantation

Cited by 41 publications

References 17 publications

Soluble HLA-G: Are they clinically relevant?

Soluble HLA-G: Are they clinically relevant?

CTLA-4-mediated regulatory phenotype of T-cells in tolerant lung recipients

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