Human leukocyte antigen–G allele polymorphisms have evolved following three different evolutionary lineages based on intron sequences

Cervera, Isabel; Herráiz, M.; Peñaloza, J.; Barbolla, Maria Luz; Jurado, María; Macedo, Jacqueline; Vidart, José Antonio; Martı́nez-Laso, Jorge

doi:10.1016/j.humimm.2010.07.003

Cited by 12 publications

(5 citation statements)

References 38 publications

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“…These data also confirm the differences in evolution of the classic and nonclassic HLA class I alleles such as HLA-G‫,ء‬ where the introns are mainly involved in the maintenance polymorphism [37]. The evolution uses the same mechanisms but in a different way, depending of the usefulness of the proteins subjected to this evolutionary process.…”

Section: Phylogenetic Analysessupporting

confidence: 73%

Polymorphism of the HLA-B*15 group of alleles is generated following 5 lineages of evolution

Martı́nez-Laso¹,

Herráiz²,

Vidart³

et al. 2011

Human Immunology

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Section: Phylogenetic Analysessupporting

confidence: 73%

Polymorphism of the HLA-B*15 group of alleles is generated following 5 lineages of evolution

Martı́nez-Laso¹,

Herráiz²,

Vidart³

et al. 2011

Human Immunology

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“…The new allele described confirms that evolutionary forces to generate HLA‐G polymorphism are conducted to avoid new proteins with specific evolutionary mechanism as point mutation, gene conversion, convergent evolution or inversion event (present paper) mainly in introns (4).…”

supporting

confidence: 78%

The novel HLA‐G01:03:01:02* allele differs from G01:03:01:01* by a possible inversion event in intron 3

et al. 2011

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“…A recent study investigated the haplotype structure of the 3′ UTR of the HLA‐G gene (26). According to this study, the del/G haplotype fits in the so‐called UTR‐3′‐extended haplotype, which is associated with three alleles G*010401, G*010403 and G*010404, which are closely related in terms of evolution (27). Intriguingly, G*010401, the most prevalent allele associated to this haplotype, was previously shown to be a high producer allele (28).…”

Section: Discussionmentioning

confidence: 99%

Association of the HLA‐G gene +3142C>G polymorphism with systemic lupus erythematosus

et al. 2011

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Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease that affects several organs and systems. Its etiology remains unknown, although it is probably multifactorial. The human leukocyte antigen G (HLA-G) is a nonclassic major histocompatibility complex I molecule characterized by restricted expression and low DNA polymorphism. HLA-G plays a role in immunosuppression through different mechanisms. In inflammatory diseases, it has been postulated that HLA-G expression may be a possible mechanism of tissue protection against exacerbated inflammatory response. On the 3' untranslated region (3' UTR) of the HLA-G gene, there is an insertion/deletion polymorphism of 14 bp (rs1704) that was shown to influence the mRNA stability. The influence of this polymorphism in disease susceptibility is controversial. Also in the 3' UTR there is a single nucleotide polymorphism C/G (rs1063320) on the position +3142, at a possible binding site for microRNAs (miRNAs) and having an influence on miRNA affinity. In this study, we analyzed the +3142C>G and the 14 bp polymorphisms in 195 SLE European-derived female patients. Our findings show a significant increase of the +3142G allele frequency among patients as compared with controls (0.58 vs 0.47, P = 0.011). Also, patients presented a higher frequency of the GG genotype (OR = 1.90, 95% CI: 1.08-3.42). Double heterozygotes for the two polymorphisms presented a milder mean systemic lupus erythematosus disease activity index (SLEDAI) than heterozygotes for only one of the variants or non-heterozygous individuals (1.56 vs 3.15 and 3.26, respectively, corrected P = 0.044). These results suggest the involvement of the HLA-G molecule on SLE susceptibility and outcome.

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Human leukocyte antigen–G allele polymorphisms have evolved following three different evolutionary lineages based on intron sequences

Cited by 12 publications

References 38 publications

Polymorphism of the HLA-B*15 group of alleles is generated following 5 lineages of evolution

Polymorphism of the HLA-B*15 group of alleles is generated following 5 lineages of evolution

The novel HLA‐G01:03:01:02* allele differs from G01:03:01:01* by a possible inversion event in intron 3

Association of the HLA‐G gene +3142C>G polymorphism with systemic lupus erythematosus

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Human leukocyte antigen–G allele polymorphisms have evolved following three different evolutionary lineages based on intron sequences

Cited by 12 publications

References 38 publications

Polymorphism of the HLA-B*15 group of alleles is generated following 5 lineages of evolution

Polymorphism of the HLA-B*15 group of alleles is generated following 5 lineages of evolution

The novel HLA‐G*01:03:01:02 allele differs from G*01:03:01:01 by a possible inversion event in intron 3

Association of the HLA‐G gene +3142C>G polymorphism with systemic lupus erythematosus

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The novel HLA‐G01:03:01:02* allele differs from G01:03:01:01* by a possible inversion event in intron 3