Abstract:Lymph node is a secondary lymphoid organ with highly organized and compartmentalized structure. Fibroblastic reticular cells (FRC) integrate LN structure, and are characterized by podoplanin expression (PDPN) and lack of CD31. FRCs are involved in several immune response processes but the mechanism is still under investigation. Another cell population present in the lymph node is the one lacking PDPN and CD31, so called, double negative population (DNC). FRCs and DNCs are described as chemokines producers, con… Show more
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