Human mast cell chemokines receptors: implications for mast cell tissue localization in asthma

Scott, K.; Bradding, Peter

doi:10.1111/j.1365-2222.2005.02277.x

Cited by 20 publications

(15 citation statements)

References 34 publications

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“…A variety of chemokine receptors are expressed in MCs that are differentiated from different origins. It has been reported that CC chemokine receptors, including CCR1 through CCR5, and CXC chemokine receptors including CXCR1 through CXCR6, are involved in mast cell migration (Scott and Bradding, 2005). Although CCR2-mediated signals in MCs stimulate histamine and leukotriene release, and further bronchial hyperreactivity, prior study of the regulation of CCR2 expression and CCR2-associated functional mechanism in MCs has been limited (Campbell et al, 1999).…”

Section: Discussionmentioning

confidence: 97%

“…The mechanism controlling MCs recruitment and movement within tissue is not known; however, the interaction of the chemokine receptor with the chemokine has been considered as a main regulatory signal for MCs attraction (Scott and Bradding, 2005). A variety of chemokine receptors are expressed in MCs that are differentiated from different origins.…”

Section: Discussionmentioning

confidence: 99%

“…XC receptor (XCR1) and CX 3 C receptor (CX 3 CR1) bind C (γ) chemokine and CX 3 C (δ) chemokine, respectively (Murphy et al, 2000). It has been reported that human MCs of different origin can express CC chemokine receptors: CCR1, CCR3, CCR4, CCR5 and CCR7 (Scott and Bradding, 2005). Recently, both CCR2 and CCR3 have been shown to play an important role in allergic inflammation induced by MCs (Campbell et al, 1999;Price et al, 2003).…”

Section: Introductionmentioning

confidence: 96%

See 2 more Smart Citations

Differential regulation of CC chemokine receptors by 9-cis retinoic acid in the human mast cell line, HMC-1

Yun

Lee

et al. 2006

Life Sciences

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

See 1 more Smart Citation

Differential regulation of CC chemokine receptors by 9-cis retinoic acid in the human mast cell line, HMC-1

Yun

Lee

et al. 2006

Life Sciences

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“…SCF (c-kit ligand) is produced by the epithelium, smooth muscle and fibroblasts and is upregulated in asthma (Al Muhsen et al 2004;Plante et al 2006). In addition, CXCL8 and CXCL10 produced by airway smooth muscle itself are not only important in the recruitment of mast cells into this compartment by interacting with their receptors CXCR3 and CXCR2 respectively, but also in their priming for enhanced mediator secretion (Woodman et al 2006;Scott & Bradding 2005). In the reverse direction, mast cells secrete CCL19 that, through its receptor CCR7, stimulates airway smooth muscle migration and probably contributes to the smooth muscle hyperplasia .…”

Section: Mast Cellsmentioning

confidence: 96%

Pathogenesis of Asthma

Holgate¹

2008

Clin Experimental Allergy

692

486

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While asthma is considered an inflammatory disorder of the conducting airways, it is becoming increasingly apparent that the disease is heterogeneous with respect to immunopathology, clinical phenotypes, response to therapies, and natural history. Once considered purely an allergic disorder dominated by Th2-type lymphocytes, IgE, mast cells, eosinophils, macrophages, and cytokines, the disease also involves local epithelial, mesenchymal, vascular and neurologic events that are involved in directing the Th2 phenotype to the lung and through aberrant injury-repair mechanisms to remodeling of the airway wall. Structural cells provide the necessary "soil" upon which the "seeds" of the inflammatory response are able to take root and maintain a chronic phenotype and upon which are superimposed acute and subacute episodes usually driven by environmental factors such as exposure to allergens, microorganisms, pollutants or caused by inadequate antiinflammatory treatment. Greater consideration of additional immunologic and inflammatory pathways are revealing new ways of intervening in the prevention and treatment of the disease. Thus increased focus on environmental factors beyond allergic exposure (such as virus infection, air pollution, and diet) are identifying targets in structural as well as immune and inflammatory cells at which to direct new interventions.

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“…However, the chemokine system is complex, and further work is urgently needed using human lung cells, as they differ from both cultured mast cells and those from animal models. For a more detailed discussion, see Scott and Bradding [32].…”

Section: Mast Cells and Smooth Musclementioning

confidence: 98%

New targets for modifying mast cell activation in asthma

Ennis

2006

Curr Allergy Asthma Rep

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Mast cells play a central role in innate immunity and in orchestrating the asthmatic response. Current medication relies on beta-agonists to relieve bronchoconstriction and steroids to reduce inflammation. However, recently drugs such as leukotriene-receptor antagonists and anti-immunoglobulin E have come on to the market. In this paper, a number of potential targets for modifying mast cell activation in asthma are reviewed. Some are already under study, including clinical trials (eg, tryptase inhibitors); others are more speculative (eg, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity). In each case, where data are available, the action of the agents on human lung mast cells is described.

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Human mast cell chemokines receptors: implications for mast cell tissue localization in asthma

Cited by 20 publications

References 34 publications

Differential regulation of CC chemokine receptors by 9-cis retinoic acid in the human mast cell line, HMC-1

Differential regulation of CC chemokine receptors by 9-cis retinoic acid in the human mast cell line, HMC-1

Pathogenesis of Asthma

New targets for modifying mast cell activation in asthma

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