Human Mast Cells Modulate Proliferation and Cytokine Production by CD8+ T Lymphocytes

Mast cells in vulnerable atherosclerotic plaques – a view to a kill

“…In addition, mast cells are present in most vascularized tissues, where they reside in the vicinity of blood vessels and lymphatic vessels [24]. Although mast cells are best known for their ability to release histamine and to induce IgE‐mediated type I hypersensitivity reactions [25, 26], they also initiate and regulate inflammatory responses, defend the host against bacterial and parasitic pathogens, regulate vascular functions, participate in wound healing and neovascularization and recruit and activate other types of inflammatory cells, and stromal cells, as well [27–30].…”

Expression of functional major histocompatility complex class II molecules on HMC-1 human mast cells

“…In the presence of interleukin-3 (IL-3) -secreting T cells rodent mast cell progenitors undergo proliferation and specific differentiation toward the mucosal phenotype [1][2][3][4][5], which is considered a major mechanism of defense during parasite infestation [6][7][8][9][10]. On the other hand, it is well established that both rodent and human mast cells are one main source for several cytokines [tumor necrosis factor ␣ (TNF-␣), IL-3, IL-4, IL-5, IL-6, IL-8, IL-13] [11][12][13][14][15][16][17][18][19] and growth factors [20,21] that can regulate directly or indirectly, the development, phenotype, and function of T [22][23][24][25][26][27][28] and B cells [21]. Subsequently, mast cells and T cells seem to complement the functions of each other, thus contributing to the cytokine pool that leads to chronic inflammation.…”

Products from human mast cell line cells enhance the production of interferon‐γ by CD8+ and CD4+ T cells

“…A possible implication of our findings might be that together with the decreased proliferation the increased levels of IFN‐γ over IL‐4 could account for a negative feedback system by which mast cells locally down‐regulate allergen‐induced Th2 responses both via the CD8 + 44 and the CD4 + T cells. However, whether HMC‐1 cells resemble normal mast cells and to what extent normal mast cells differ from mast cells from allergic subjects remains to be investigated.…”