Human meningitis caused by 
               Streptococcus suis

Zalas‐Więcek, Patrycja; Michalska, Anna; Grąbczewska, Edyta; Olczak, Anita; Pawłowska, Małgorzata; Gospodarek, Eugenia

doi:10.1099/jmm.0.046599-0

Cited by 26 publications

(23 citation statements)

References 13 publications

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“…Since then, this pathogen has spread all over the world. The human Streptococcus suis was epidemic in most Europe countries (3,4), as well as in Asian countries, such as Vietnam and Thailand (5-7). In China, two outbreaks of human streptococcosis have occurred, affecting more than 100 people and causing 39 deaths (8).…”

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Novel Variant Serotype of Streptococcus suis Isolated from Piglets with Meningitis

Pan

Wang³

et al. 2015

Appl Environ Microbiol

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cStreptococcus suis is an emerging zoonotic pathogen causing severe infections in pigs and humans. In previous studies, 33 serotypes of S. suis have been identified using serum agglutination. Here, we describe a novel S. suis strain, CZ130302, isolated from an outbreak of acute piglet meningitis in eastern China. Strong pathogenicity of meningitis caused by strain CZ130302 was reproduced in the BALB/c mouse model. The strain showed a high fatality rate (8/10), higher than those for known virulent serotype 2 strains P1/7 (1/10) and 9801 (2/10). Cell adhesion assay results with bEnd.3 and HEp2 cells showed that CZ130302 was significantly close to P1/7 and 9801. Both the agglutination test and its complementary test showed that strain CZ130302 had no strong cross-reaction with the other 33 S. suis serotypes. The multiplex PCR assays revealed no specified bands for all four sets used to detect the other 33 serotypes. In addition, genetic analysis of the whole cps gene clusters of all serotypes was performed in this study. The results of comparative genomics showed that the cps gene cluster of CZ130302, which was not previously reported, showed no homology to the gene sequences of the other strains. Especially, the wzy, wzx, and acetyltransferase genes of strain CZ130302 are phylogenetically distinct from strains of the other 33 serotypes. Therefore, this study suggested that strain CZ130302 represents a novel variant serotype of S. suis (designated serotype Chz) which has a high potential to be virulent and associated with meningitis in animals. Streptococcus suis causes meningitis and septicemia in pigs and is also known as a zoonotic agent (1). Human infections of S. suis were first reported in Denmark in 1968 (2). Since then, this pathogen has spread all over the world. The human Streptococcus suis was epidemic in most Europe countries (3, 4), as well as in Asian countries, such as Vietnam and Thailand (5-7). In China, two outbreaks of human streptococcosis have occurred, affecting more than 100 people and causing 39 deaths (8). More and more S. suis infections from China, Thailand, Hong Kong, Taiwan, and Singapore have been reported, which indicates that S. suis has been an important cause of adult meningitis, endocarditis, septicemia, and arthritis in Asia (9).The serotyping of S. suis isolates rests on the basis of the antigenicity of their capsular polysaccharides (CPs); 35 serotypes have been identified by agglutination tests (10). With the development of sequence analysis of 16S rRNA and cpn60 genes in S. suis, the original S. suis serotypes 32 and 34 were reclassified as Streptococcus orisratti (11). Phylogenetic analyses of the cps gene cluster, conserved Wzy polymerase, Wzx flippase, and glycosyltransferase are all taken as important means of classifying a novel serotype (12). Multiplex PCR assays against the specific genes of the cps clusters have also been developed to identify serotypes in S. suis (13)(14)(15).From March to May 2013, strain CZ130302 caused an outbreak of streptococcosis in piglets at ...

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Novel Variant Serotype of Streptococcus suis Isolated from Piglets with Meningitis

Pan

Wang³

et al. 2015

Appl Environ Microbiol

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“…É comensal nas vias aéreas superiores, aparelho reprodutivo e digestivo dos suínos afectados, que constituem o seu principal reservatório. 4,8 Estes podem ser portadores assintomáticos ou adoecerem, transmitindo a infecção entre si, por via vertical ou horizontal, e podendo infectar os humanos.…”

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“…2 Tal como sucede na meningite pneumocócica, é fundamental a instituição precoce da terapêutica, em dosagem e duração sobreponíveis aos utilizados naquela doença. 4 Ainda que controverso, 12 o uso de dexametasona, equaciona-se na tentativa de debelar a hipoacusia neurossensorial, sequela desta meningite em mais de 50% dos casos. 3 O presente caso clínico é o quinto relato de S. suis em Portugal [13][14][15] (Tabela 1).…”

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“…Efetivamente, indivíduos cuja atividade implique contacto com estes animais ou a manipulação da sua carne têm risco acrescido de adoecer face à população em geral. 4 Na última década os relatos de infecção causada por S. suis têm vindo a aumentar, devido à ocorrência de surtos epidémicos no Sudeste Asiático, onde a densidade de suínos é elevada, 5,6 pelo que é também classificada como zoonose emergente. 7 Além de descreverem o presente caso clínico, os autores revêm também os relatos de doença por S. suis publicados em Portugal: epidemiologia inerente, apresentação e evolução, alertando para um agente cuja prevalência não deve ser menosprezada.…”

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Meningite Bacteriana Aguda como Doença Ocupacional

et al. 2014

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Streptococcus suis is a zoonotic pathogen with worldwide distribution, responsible for more than 700 human cases globally reported. This infection affects mostly men, exposed to pig or pork, which leads to its usual classification as an occupational disease. We report a case of acute bacterial meningitis in a 44 years old male. According to his past medical history, the patient had alcohol consumption and worked in a restaurant as a piglet griller. Microbiological examination of blood and CSF revealed S. suis. After 14 days of ceftriaxone the patient fully recovered. The authors review the clinical reports previously described in Portugal. In all of them was possible to identify risk exposition to pork. We alert to this microorganism’s importance in Portugal where it is probably underdiagnosed.<br /><strong>Keywords:</strong> Occupational Diseases; Occupational Exposure; Meningitis, Bacterial; Streptococcal Infections; Streptococcus suis; Portugal.

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“…U 24,2% pacjentów rozwijała się sepsa z objawami zespołu wstrząsu toksycznego. Częstość zakażeń o cięż-kim przebiegu była znacznie wyższa niż w przypadku dobrze poznanych paciorkowców wywołujących infekcje u ludzi (14,34). Mimo to nie udowodniono jeszcze, że zakażenia mogą przenosić się horyzontalnie z czło-wieka na człowieka.…”

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New insight into bacterial zoonotic pathogens posing health hazards to humans

Ciszewski¹,

Czekaj²,

Szewczyk³

2015

Med Pr

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StreszczenieW artykule omówiono zmiany, jakim podlegają patogeny zwierzęce, które na drodze ewolucji stały się chorobotwórcze dla ludzi. Ryzyko zakażenia dotyczy szczególnie osób mających bezpośredni kontakt ze zwierzętami w ramach obowiązków zawodowych -weterynarzy, hodowców, osób pracujących w zakładach zajmujących się ubojem lub przetwórstwem surowców pochodzenia zwierzęcego. W artykule przedstawiono drobnoustroje wskazywane w raportach epidemiologicznych Europejskiego Centrum Zapobiegania i Kontroli Chorób (European Centre for Disease Prevention and Control, ECDC), które od 19 lat gromadzi i publikuje w postaci raportów dane na temat zoonoz ze wszystkich krajów członkowskich Unii Europejskiej. Obecnie ECDC monitoruje występowanie chorób wywoływanych przez 11, uznanych za najważniejsze, czynników etiologicznych zoonoz, z których 7 stanowią patogeny bakteryjne: Salmonella spp., Campylobacter spp., Listeria monocytogenes, Mycobacterium bovis, Brucella spp., Coxiella burnetti oraz Verotoxin-producing E. coli (VTEC) / Shiga-like toxin-producing E. coli (STEC). Za szczególnie ważne uważa się te, które mogą rozprzestrzeniać się za pośrednictwem żywności. W artykule uwzględniono także wybrane nowe zagrożenia, niesione przez gatunki jeszcze niemonitorowane -paciorkowce Streptococcus iniae, S. suis i S. dysgalactiae oraz gronkowce Staphylococcus intermedius i S. pseudintermedius. Drobnoustroje te w ciągu ostatnich lat przełama-ły barierę międzygatunkową. Przyczyny tego zjawiska nie są znane, ale wiąże się je ze zmiennością drobnoustrojów oraz ich adaptacją do życia w zmieniającym się środowisku, co wynika z łatwości rearanżacji DNA i poziomego transferu genów. Skalę problemu nowych infekcji odzwierzęcych odzwierciedla istotny wzrost liczby publikacji w tej dziedzinie w ostatnich latach. Med. Pr. 2014;65(6):819-829 Słowa kluczowe: epidemiologia, bakteryjne infekcje odzwierzęce, ewolucja patogenów, przełamywanie barier międzygatunko-wych, różnorodność genetyczna, poziomy transfer genów AbstractThis article presents the problem of evolutionary changes of zoonotic pathogens responsible for human diseases. Everyone is exposed to the risk of zoonotic infection, particularly employees having direct contact with animals, i.e. veterinarians, breeders, butchers and workers of animal products' processing industry. The article focuses on pathogens monitored by the European Centre for Disease Prevention and Control (ECDC), which has been collecting statistical data on zoonoses from all European Union countries for 19 years and publishing collected data in annual epidemiological reports. Currently, the most important 11 pathogens responsible for causing human zoonotic diseases are being monitored, of which seven are bacteria: Salmonella spp., Campylobacter spp., Listeria monocytogenes, Mycobacterium bovis, Brucella spp., Coxiella burnetti and Verotoxin-producing E. coli (VTEC) / Shiga-like toxin producing E. coli (STEC). As particularly important are considered foodborne pathogens. The article also includes new emerging zoonotic ba...

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Human meningitis caused by Streptococcus suis

Cited by 26 publications

References 13 publications

Novel Variant Serotype of Streptococcus suis Isolated from Piglets with Meningitis

Novel Variant Serotype of Streptococcus suis Isolated from Piglets with Meningitis

Meningite Bacteriana Aguda como Doença Ocupacional

New insight into bacterial zoonotic pathogens posing health hazards to humans

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