Human Meniscus Allografts’ in Vivo Size and Motion Characteristics

Rankin, Marc; Noyes, Frank R.; Barber-Westin, Sue D.; Hushek, Stephen G.; Seow, Albert

doi:10.1177/0363546505278706

Cited by 37 publications

(26 citation statements)

References 40 publications

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“…In our study, extrusion of meniscal allografts in either the coronal or sagittal plane obviously changed with time; the anterior horn and the posterior horn both moved anteriorly because they belong to an integral unit. These areas had synergic movement similar to that in the studies by Rankin et al 23 and Scholes et al 24 …”

Section: Discussionsupporting

confidence: 77%

Correlation analysis of potential factors influencing graft maturity based on MRI after lateral meniscal allograft transplantation

Ren

Zhang

Yu³

et al. 2020

Sci Rep

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The aim of this respective study was to assess the graft signal/noise quotient (SNQ) value and associated factors based on magnetic resonance imaging (MRI) after lateral meniscal allograft transplantation (LMAT). Patients with LMAT were included. The SNQ, width of the anterior horn (WAH), width of the midbody (WMB), width of the posterior horn (WPH) of each lateral meniscus, coronal graft extrusion (CGE), the anterior cartilage meniscus distance (ACMD) and the posterior cartilage meniscus distance (PCMD) were measured using MRI and tested by multivariate stepwise regression analysis. The relative percentage of extrusion (PRE) was calculated. Seventy-one male patients were examined, and 7 patients were lost to follow-up. The SNQ of the meniscus increased from immediately after surgery to 6 months postoperatively, decreased from 6 to 12 months, increased from 12 to 24 months, and increased from 24 to 36 months. The mean SNQ had a significant negative association with the WPH and CGE at 6 months (p < 0.05), the WPH at 1 year (p < 0.05), the PRE of CGE (CPRE) at 2 years (p < 0.05), and the PCMD, CPRE, and PRE of the PCMD (PPRE) at 3 years (p < 0.01) postoperatively. Multivariate stepwise regression analysis showed that the WPH at 6 months, WPH at 1 year, WMD and PCMD at 2 years, and WMD, ACMD and CGE at 3 years were significant independent factors correlated with the mean SNQ of grafts in different periods. Maturation of meniscal grafts fluctuated with time. The maturation process occupied the main role before 1 year postoperatively, but after the maturation process, tearing of the meniscal allograft played the leading role. Changes in an allograft's location had an obvious association with the SNQ. The WPH influenced the graft SNQ value at 6 months and 1 year postoperatively, but after the maturation process, the WMB and graft extrusion played the same roles.

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Section: Discussionsupporting

confidence: 77%

Correlation analysis of potential factors influencing graft maturity based on MRI after lateral meniscal allograft transplantation

Ren

Zhang

Yu³

et al. 2020

Sci Rep

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“…Based on a subpopulation of 1497 patients there is a complication rate of 15.6% (2.0%–51.4%) or 663 reported complications. A meniscal tear of the allograft is the most frequent complication, followed by debris removal in the joint space [5, 7, 9–16, 18, 19, 21–27, 29–31, 34–40, 42, 44, 45, 47, 50–58] (see Appendix C for a complete overview of all complications reported).…”

Section: Resultsmentioning

confidence: 99%

“…When evaluating the allograft with arthroscopy most authors refer to good integration of the allograft in situ. Some studies refer to shrinking of the allograft [9, 14, 29, 32, 36, 50, 56]. …”

Section: Discussionmentioning

confidence: 99%

Meniscal allograft transplantation: a meta-analysis

Bruycker

Verdonk

2017

SICOT-J

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Purpose: This meta-analysis evaluates the mid- to long-term survival outcome of MAT (meniscal allograft transplantation). Potential prognosticators, with particular focus on chondral status and age of the patient at the time of transplantation, were also analysed. Study design: Meta-analysis. Methods: An online database search was performed using following search string: “meniscal allograft transplantation” and “outcome”. A total of 65 articles were analysed for a total of 3157 performed MAT with a mean follow-up of 5.4 years. Subjective and clinical data was analysed. Results: The subjective and objective results of 2977 patients (3157 allografts) were analysed; 70% were male, 30% were female. Thirty-eight percent received an isolated MAT. All other patients underwent at least one concomitant procedure. Lysholm, Knee injury and Osteoarthritis Outcome (KOOS), International Knee Documentation Committee (IKDC) and Visual Analogue Scale (VAS) scores were analysed. All scores showed a good patient satisfaction at long-term follow-up. The mean overall survival rate was 80.9%. Complication rates were comparable to standard meniscal repair surgery. There was a degenerative evolution in osteoarthritis with at least one grade in 1760 radiographically analysed patients. Concomitant procedures seem to have no effect on the outcome. Age at transplantation is a negative prognosticator. The body mass index (BMI) of the patient shows a slightly negative correlation with the outcome of MAT. Conclusions: MAT is a viable solution for the younger patient with chronic pain in the meniscectomised knee joint. The complications are not severe and comparable to meniscal repair. The overall failure rate at final follow-up is acceptable and the allograft heals well in most cases, but MAT cannot be seen as a definitive solution for post-meniscectomy pain. The correct approach to the chronic painful total meniscectomised knee joint thus requires consideration of all pathologies including alignment, stability, meniscal abnormality and cartilage degeneration. It requires possibly combined but appropriate action in that order.

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“…42,45,46,53 A 100% follow-up was obtained in these prospective studies. The cryopreserved transplants were followed a mean of 40 months (range, 24-69 months) postoperatively and the irradiated transplants a mean of 44 months postoperatively (range, 22-111 months).…”

Section: Meniscus Transplantationmentioning

confidence: 92%

Meniscus Repair and Transplantation: A Comprehensive Update

Noyes¹,

Heckmann²,

Barber-Westin³

2012

Journal of Orthopaedic & Sports Physical Therapy

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101

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Synopsis Preservation of meniscal tissue is paramount for long-term joint function, especially in younger patients who are athletically active. Many studies have reported encouraging results following repair of meniscus tears for both simple longitudinal tears located in the periphery and complex multiplanar tears that extend into the central third avascular region. This operation is usually indicated in active patients who have tibiofemoral joint line pain and are less than 50 years of age. However, not all meniscus tears are repairable, especially if considerable damage has occurred. In select patients, meniscus transplantation may restore partial load-bearing meniscus function, decrease symptoms, and provide chondroprotective effects. The initial postoperative goal after both meniscus repair and transplantation is to prevent excessive weight bearing, as high compressive and shear forces can disrupt healing meniscus repair sites and transplants. Immediate knee motion and muscle strengthening are initiated the day after surgery. Variations are built into the rehabilitation protocol according to the type, location, and size of the meniscus repair, if concomitant procedures are performed, and if articular cartilage damage is present. Meniscus repairs located in the periphery heal rapidly, whereas complex multiplanar repairs tend to heal more slowly and require greater caution. The authors have reported the efficacy of the rehabilitation programs and the results of meniscus repair and transplantation in many studies. J Orthop Sports Phys Ther 2012;42(3):274–290, Epub 4 September 2011. doi:10.2519/jospt.2012.3588

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Human Meniscus Allografts’ in Vivo Size and Motion Characteristics

Cited by 37 publications

References 40 publications

Correlation analysis of potential factors influencing graft maturity based on MRI after lateral meniscal allograft transplantation

Correlation analysis of potential factors influencing graft maturity based on MRI after lateral meniscal allograft transplantation

Meniscal allograft transplantation: a meta-analysis

Meniscus Repair and Transplantation: A Comprehensive Update

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