Human Metapneumovirus Infection in Young Children Hospitalized With Respiratory Tract Disease

Foulongne, Vincent; Guyon, G.; Rodière, M.; Segondy, Michel

doi:10.1097/01.inf.0000207480.55201.f6

Cited by 131 publications

(119 citation statements)

References 40 publications

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“…8 %). A similar seasonality has been observed in studies performed in temperate regions [10,17,19,20]. An interesting finding of this study was an unusually high frequency (51 .…”

Section: Discussionsupporting

confidence: 90%

Hospitalization rates for human metapneumovirus infection among 0- to 3-year-olds in Gipuzkoa (Basque Country), Spain

et al. 2008

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SUMMARYNumerous studies have been published on human metapneumovirus (HMPV) infection, but few have been population based. The main aim of this study was to estimate the incidence rate of hospitalization for community-acquired HMPV infection in infants and children aged <3 years. Between July 2004 and June 2007, 796 episodes (742 patients) of community-acquired acute respiratory infection were hospitalized. HMPV was detected in 90 episodes (11 . 3%). Fifty-nine episodes occurred in infants aged <1 year. The mean length of hospital stay was 6 . 2 days (range 2-31 days). Thirteen children required admission to the intensive care unit. Viral co-infections were detected in 46 episodes (51 . 1%). The incidence rate of hospitalization per 1000 inhabitants was 2 . 6 (95 % CI 2 . 1-3 . 2), lower than that for respiratory syncytial virus, but higher than that observed for the influenza and parainfluenza viruses. HMPV is a major respiratory pathogen that leads to a high hospitalization rate.

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“…8 %). A similar seasonality has been observed in studies performed in temperate regions [10,17,19,20]. An interesting finding of this study was an unusually high frequency (51 .…”

Section: Discussionsupporting

confidence: 90%

Hospitalization rates for human metapneumovirus infection among 0- to 3-year-olds in Gipuzkoa (Basque Country), Spain

et al. 2008

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“…The hMPV/RSV coinfection is frequent and could be more severe than infection by either virus and is marked by increased hospitalization rates (26,30,31).…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of Human Metapneumovirus and Respiratory Syncytial Virus and Coinfection With Both in Hospitalized Children With Acute Respiratory Infection in South of Iran

Moattari

Aleyasin

Fyruzi

et al. 2015

Arch Pediatr Infect Dis

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Background: Viral infections are the most frequent causes of morbidity and mortality due to respiratory dysfunction worldwide, especially in children under five years of age. Several studies have reported the association of human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) with acute respiratory infection. Objectives: The present study aimed to investigate the prevalence of hMPV, RSV, and their coinfection in children with respiratory symptoms hospitalized in Shiraz City, Fars Province, Iran. The study also attempted to determine the association between asthma and wheezing with hMPV, RSV, and coinfection with both in studied children. Patients and Methods:The study included 280 younger than five years old children with non-influenza infection that were hospitalized for respiratory infection from 2011 to 2013. Nasopharyngeal swabs were collected from patients and tested for RSV and hMPV with reverse transcriptase polymerase chain reaction. Results: The hMPV and RSV were detected in 44 (15.7%) and 84 (30.0%) samples, respectively. Coinfection with both viruses was found in ten patients (3.57%). The incidence of hMPV and RSV infections were observed in children younger than one year old. Infections occurred predominantly from October to April. The most common clinical symptoms were bronchiolitis, wheezing, and cough. Conclusions: Infection with hMPV and RSV are most frequent infections among pediatric patients with respiratory tract symptoms. Coinfection with these viruses may exacerbate the clinical symptoms and increase hospitalization rates, especially in children younger than one year old.

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“…RVs are the predominant aetiological agents associated with exacerbations; however, other viruses, such as coronavirus, influenza virus, adenovirus, RSV and parainfluenza virus, Mycoplasma pneumoniae and Chlamydophila pneumoniae have been also identified, although to a lesser extent [39]. Among the more recently identified viruses, human metapneumovirus has been associated with wheezing episodes, mostly in younger children, whereas bocavirus claims ,5% of asthma exacerbations [40][41][42]. Nevertheless, RV remains by far the major player in asthma exacerbations; it has also been associated with bronchiolitis, although clearly distinct from asthma-related diseases, and pneumonia [43,44].…”

Section: Infection Among Factors Precipitating Asthma Exacerbationsmentioning

confidence: 99%

Childhood asthma and infection: virus-induced exacerbations as determinants and modifiers: Figure 1–

Xepapadaki¹,

Papadopoulos²

2010

Eur Respir J

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Respiratory infections have been implicated in the origin and exacerbation of asthma in a variety of ways; however, systemisation of this knowledge in a way helpful for disease management remains suboptimal.Several conceptual issues need to be taken into account: the fact that the effects of an infection may vary according to genetic background, the current immune status of the host, and parallel environmental stimuli, in addition to the particular infectious agent itself. Moreover, childhood is a very special period because of the continuous processes taking place, such as neural, immune and respiratory maturation.Epidemiological studies have convincingly demonstrated that the majority of asthma exacerbations, in both adults and children, follow viral upper respiratory tract infections. Asthma exacerbations are still often unresponsive to current asthma treatment, and new therapeutic approaches are required.This review presents current knowledge on the associations between infection and exacerbation of established asthma with respect to definitions, epidemiology, mechanisms and treatment.

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Human Metapneumovirus Infection in Young Children Hospitalized With Respiratory Tract Disease

Abstract: hMPV is a frequent cause of RTD in young children. hMPV/RSV coinfection is frequent and could be more severe than a single hMPV or RSV infection.

Cited by 131 publications

References 40 publications

Hospitalization rates for human metapneumovirus infection among 0- to 3-year-olds in Gipuzkoa (Basque Country), Spain

Hospitalization rates for human metapneumovirus infection among 0- to 3-year-olds in Gipuzkoa (Basque Country), Spain

The Prevalence of Human Metapneumovirus and Respiratory Syncytial Virus and Coinfection With Both in Hospitalized Children With Acute Respiratory Infection in South of Iran

Childhood asthma and infection: virus-induced exacerbations as determinants and modifiers: Figure 1–

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