2022
DOI: 10.1111/obr.13409
|View full text |Cite
|
Sign up to set email alerts
|

Human microbiome and metabolic health: An overview of systematic reviews

Abstract: Summary To summarize the microbiome's role in metabolic disorders (insulin resistance, hyperglycemia, type 2 diabetes, obesity, hyperlipidemia, hypertension, nonalcoholic fatty liver disease [NAFLD], and metabolic syndrome), systematic reviews on observational or interventional studies (prebiotics/probiotics/synbiotics/transplant) were searched in MEDLINE and Embase until September 2020. The 87 selected systematic reviews included 57 meta‐analyses. Methodological quality (AMSTAR2) was moderate in 62%, 12% low,… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

1
50
0
2

Year Published

2022
2022
2024
2024

Publication Types

Select...
8
1
1

Relationship

0
10

Authors

Journals

citations
Cited by 73 publications
(53 citation statements)
references
References 143 publications
(312 reference statements)
1
50
0
2
Order By: Relevance
“…However, the prospective protocol may be not particularly useful, as our research team is very familiar with the overview using the evidence mapping approach (Lu et al, 2021a;Lu et al, 2021b;Lu et al, 2022). Second, similar to other published overviews (Lu et al, 2021a;Michels et al, 2022), only two large bibliographic databases, namely, PubMed and Embase were searched rather than searching other databases, such as the Cochrane Library, which is collected in PubMed, although may have a time lag. Third, only quantitative systematic reviews published in English were included and Chinese papers were excluded.…”
Section: Discussionmentioning
confidence: 99%
“…However, the prospective protocol may be not particularly useful, as our research team is very familiar with the overview using the evidence mapping approach (Lu et al, 2021a;Lu et al, 2021b;Lu et al, 2022). Second, similar to other published overviews (Lu et al, 2021a;Michels et al, 2022), only two large bibliographic databases, namely, PubMed and Embase were searched rather than searching other databases, such as the Cochrane Library, which is collected in PubMed, although may have a time lag. Third, only quantitative systematic reviews published in English were included and Chinese papers were excluded.…”
Section: Discussionmentioning
confidence: 99%
“…Even though the definition of a healthy microbiome is still missing, diverse medical conditions have been linked to certain microbiota patterns [ 14 ]. An altered microbiota generally characterised by loss of diversity and an enrichment of opportunistic pathogens has been reported for obesity, T2DM, and MetSyn [ 15 ]. In the case of MetSyn, detailed analyses of the microbiome variance depending on the type of comorbidities, and treatment regimens are still needed to improve patient outcomes.…”
Section: Discussionmentioning
confidence: 99%
“…S9), as butyrate-producing bacteria, were reduced in aged WT mice. Age associated reduction of Rikenellaceae was unique for FXR KO mice, the reduced Rikenellaceae is also found in metabolic disorders including NAFLD [55]. FXR KO mice also have a distinct gut microbiota structure in comparison to the WT, and Bacteroidaceae are expanded in FXR KO mice [4].…”
Section: Discussionmentioning
confidence: 99%