Human microvascular endothelial cells from different fetal organs demonstrate organ-specific CAM expression

Tumor endothelial marker 1 ( Tem1 ) functions in the growth and progression of abdominal tumors

“…The fact that dramatic effects were observed in abdominal but not s.c. tumors demonstrates that the associated processes were organ-site specific. It may be relevant that normal angiogenic factors can also be expressed in an organ site-specific fashion (13)(14)(15)(16)(17)(18). One of the most important implications of the work described here is that conventional animal models for studying tumorigenesis, employing s.c. inoculation of tumor cells, may not be optimal for assessing the physiologic parameters that govern tumor cell growth and invasion in their natural environment (19,20).…”

CD34-positive primitive vessels and other structures in human fetuses: An immunohistochemical study

“…In fact, using flow cytometry, Young et al found CD34-positive cells in fetal and adult skeletal muscle [1]. Invernici et al, using CD34-positive cell lines from 12-week fetuses, demonstrated a site-dependent difference in E-selectin, ICAM-1, and VCAM-1 expression after administration of IL-1b or TNF-a [13]. In the developing muscle and its associated structures, CD34-positive fibrous tissues may express such adhesion molecules to accelerate the formation of muscle fiber and tendon bundles.…”

“…Although no in situ morphological images were presented, Invernici et al [13] reported differences in the expression of adhesion molecules on CD34positive cultured cells obtained from the human fetal heart, kidney, liver, brain, aorta, and lung at 12 weeks of gestation. Therefore, there may be a regionspecific difference in the spatial distribution of CD34-positive cells.…”

Phenotypic Heterogeneity of the Endothelium

“…Such an approach has been used to assay for differences in gene or protein expression, enzyme activity, or signaling pathways. [145][146][147][148][149][150][151][152][153] Additional studies have examined the differential effects of 1 or more agonists on different types of ECs. 154 -159 These in vitro analyses, although interesting and potentially important, must be interpreted with caution.…”