Human milk and infant intestinal mucosal glycans guide succession of the neonatal intestinal microbiota

Newburg, David S.; Morelli, Lorenzo

doi:10.1038/pr.2014.178

Cited by 76 publications

(66 citation statements)

References 37 publications

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“…In humans, vaginal birth inoculates the newborn with a set of strains that can be matched to the mother, whereas caesarean section results in colonization with skin microbes originating from various caregivers (Dominguez-Bello et al, 2010). Breast milk is also an important source of microbiota and antibodies that shape the gut microbiome (Newburg and Morelli, 2015), and introduction of solid foods brings rapid shifts in the bacterial community composition toward an adult-like microbiome (Koenig et al, 2011). Vertical transmission from mother to infant gut microbiota is sometimes behaviorally increased in mammals by feeding mother's fecal matter to their infants.…”

Section: Community Structure Of the Vertebrate Gut And Plant Root Micmentioning

confidence: 99%

Microbiota and Host Nutrition across Plant and Animal Kingdoms

Hacquard¹,

Garrido‐Oter²,

González³

et al. 2015

Cell Host & Microbe

630

470

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Plants and animals each have evolved specialized organs dedicated to nutrient acquisition, and these harbor specific bacterial communities that extend the host's metabolic repertoire. Similar forces driving microbial community establishment in the gut and plant roots include diet/soil-type, host genotype, and immune system as well as microbe-microbe interactions. Here we show that there is no overlap of abundant bacterial taxa between the microbiotas of the mammalian gut and plant roots, whereas taxa overlap does exist between fish gut and plant root communities. A comparison of root and gut microbiota composition in multiple host species belonging to the same evolutionary lineage reveals host phylogenetic signals in both eukaryotic kingdoms. The reasons underlying striking differences in microbiota composition in independently evolved, yet functionally related, organs in plants and animals remain unclear but might include differences in start inoculum and niche-specific factors such as oxygen levels, temperature, pH, and organic carbon availability.

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Section: Community Structure Of the Vertebrate Gut And Plant Root Micmentioning

confidence: 99%

Microbiota and Host Nutrition across Plant and Animal Kingdoms

Hacquard¹,

Garrido‐Oter²,

González³

et al. 2015

Cell Host & Microbe

630

470

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show abstract

“…Mothers provide critical functional and stable components over time to the microbiota. 4 Secondary sources of inocula include mouths and skin of kin, animals and objects, and the human milk microbiome. Under the guidance of diet, and especially the human milk oligosaccharides (HMOSs), microbiota continues the profound changes that are an essential part of succession and maturation.…”

Section: Neonatal Gut Microbiomementioning

confidence: 99%

“…These core members of the gut microbiota are not commensals, in which the bacteria benefit but not the host, but rather, the relationship between these bacteria and the host are more properly described as mutualism. 4 The nature of the early colonizing organisms can influence the ultimate composition of the microbiota and its interaction with the intestinal mucosa, which can bias the developing immune system toward homeostasis or dysregulation. As depicted in Figure 2, early pioneer microbiota colonization stimulates the expression of intestinal fucosyltranferase 2 at mucosal epithelial cells, which in turn, promotes fucosylation of epithelial surface molecules, fucose-dependent succession, and gut homeostasis.…”

Section: Interaction Between Microbiota and Host Mucosamentioning

confidence: 99%

“…The first defined species were pathogens, including culturable Enterobacteriaceae, Enterococci, and Staphylococci. 4 Because of the antimicrobial activity of human milk, the number of colony-forming units of these pathogenic microbes in human milk remains relatively low over time. More recently, DNA-based culture-independent techniques have revealed more microbes in human milk.…”

Section: Human Milk Contains Live Microbiotamentioning

confidence: 99%

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Neonatal Gut Microbiota and Human Milk Glycans Cooperate to Attenuate Infection and Inflammation

Newburg

He²

2015

Clinical Obstetrics &Amp; Gynecology

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Glycans of the intestinal mucosa and oligosaccharides of human milk influence the early colonization of the infant gut and establishment of mucosal homeostasis, and differences in colonization of the gut influence the ontogeny of glycans on the surface of the intestinal mucosa, proinflammatory signaling, homeostasis, and resilience to insult. This interkingdom reciprocal interaction is typical of a mutualistic symbiotic relationship. The period in which the infant gut most needs protection from hypersensitive inflammation overlaps with the recommended period of exclusive nursing; electively substituting artificial formula that lacks human milk protective glycans seems ill advised, especially for premature infants.

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“…Deep sequencing allowed to characterize in detail these populations, revealing that the human microbiota differs radically at different body sites and among individuals [2,3]. Historically microorganisms that colonize us at birth come from our mothers's vaginal tract and breast milk [7][8][9] . During the development of our immune system we are then exposed to microbial communities that enter our body through water, food, and the environment where we grow adult.…”

Section: Introductionmentioning

confidence: 99%

Mycobiota: Micro-Eukaryotes Inhabiting Our Body as Commensals or Opportunistic Pathogens

Rizzetto¹,

Filippo²,

Cavalieri³

2015

Fungal Genom Biol

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The advent of metagenomics has profoundly revolutionized our way to describe microbial communities and discover sequence based biomarkers of health and disease. Similarly to bacteria commensal fungi are an essential part of human ecosystems being involved in the normal development of the immune system and for the maintenance of healthy tissues and physiological processes. More and more frequently patterns of fungal species are associated to immune disorders and increasing evidences are accumulating of the importance to study the co-occurrence of fungal flora and its microbial counterpart to understand the cross-talk between opportunistic fungi and the mammalian host. Here we critically analyze the studies investigating thefungal communities inhabiting ourbody, addressing at what extent the selection of the approaches and the molecular markers used determine the results obtained.

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Human milk and infant intestinal mucosal glycans guide succession of the neonatal intestinal microbiota

Cited by 76 publications

References 37 publications

Microbiota and Host Nutrition across Plant and Animal Kingdoms

Microbiota and Host Nutrition across Plant and Animal Kingdoms

Neonatal Gut Microbiota and Human Milk Glycans Cooperate to Attenuate Infection and Inflammation

Mycobiota: Micro-Eukaryotes Inhabiting Our Body as Commensals or Opportunistic Pathogens

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