Human milk: From complex tailored nutrition to bioactive impact on child cognition and behavior

Weerth, Carolina de; Aatsinki, Anna-Katariina; Azad, Meghan B.; Bartol, Frank F.; Bode, Lars; Collado, María Carmen; Dettmer, Amanda M.; Field, Catherine J.; Guilfoyle, Meagan; Hinde, Katie; Kőrösi, Anikó; Lustermans, Hellen; Shukri, Nurul Husna Mohd; Moore, Sophie E.; Pundir, Shikha; Rodríguez, Juan Miguel Díaz; Slupsky, Carolyn M.; Turner, Sarah; Goudoever, Johannes B. van; Ziomkiewicz, Anna; Beijers, Roseriet

doi:10.1080/10408398.2022.2053058

Cited by 33 publications

(24 citation statements)

References 466 publications

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“…Maternal health conditions impact the content of nutrients and bioactive components of human milk [ 166 ]. Whereas hMEVs transfer functional molecules from mothers to growing infants, studying alterations of hMEV functional cargos affected by maternal factors could serve as a key to understand intergenerational health consequences [ 76 , 77 , 79 , 82 ].…”

Section: Maternal Conditions Influence Hmev Composition and Child Hea...mentioning

confidence: 99%

Human Milk Extracellular Vesicles: A Biological System with Clinical Implications

Chutipongtanate

Morrow

Newburg

2022

Cells

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The consumption of human milk by a breastfeeding infant is associated with positive health outcomes, including lower risk of diarrheal disease, respiratory disease, otitis media, and in later life, less risk of chronic disease. These benefits may be mediated by antibodies, glycoproteins, glycolipids, oligosaccharides, and leukocytes. More recently, human milk extracellular vesicles (hMEVs) have been identified. HMEVs contain functional cargos, i.e., miRNAs and proteins, that may transmit information from the mother to promote infant growth and development. Maternal health conditions can influence hMEV composition. This review summarizes hMEV biogenesis and functional contents, reviews the functional evidence of hMEVs in the maternal–infant health relationship, and discusses challenges and opportunities in hMEV research.

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Section: Maternal Conditions Influence Hmev Composition and Child Hea...mentioning

confidence: 99%

Human Milk Extracellular Vesicles: A Biological System with Clinical Implications

Chutipongtanate

Morrow

Newburg

2022

Cells

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“…Lactose is the main carbohydrate in milk, constituting around 2–8% of milk [ 15 ]. Lactose concentration is relatively constant after the colostrum phase [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…The HMOs, based on glucose, galactose, and N -acetylglucosamine with varying terminal fucose and sialic acid linkages, are the third largest compound group after lactose and lipids [ 15 ]. The HMO profile is determined by genetic factors, gestational age and stage of lactation [ 7 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

1H NMR Metabolomics of Chinese Human Milk at Different Stages of Lactation among Secretors and Non-Secretors

et al. 2022

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Human milk is an intricate, bioactive food promoting infant health. We studied the composition of human milk samples collected over an 8-month lactation using 1H NMR metabolomics. A total of 72 human breast milk samples were collected from ten Chinese mothers at eight different time points. The concentrations of ten human milk oligosaccharides (HMOs), fucose and lactose were quantified. Six of the mothers were classified as Lewis-positive secretors (Se+Le+) and four as Lewis-positive non-secretors (Se−Le+) based on the levels of 2′-fucosyllactose (2′-FL), lacto-N-fucopentaose (LNFP) II, lactodifucotetraose (LDFT) and lacto-N-neotetraose (LNnT). Acetate, citrate, short/medium-chain fatty acids, glutamine and urea showed a time-dependent trend in relation to the stage of lactation. The concentrations of 2′-FL, 3-FL (3-fucosyllactose), 3′-SL (3′-sialyllactose), LDFT, LNFP I, LNFP II, LNFP III, LNnT, LNT (lacto-N-tetraose), and fucose were statistically different between secretors and non-secretors. A temporal difference of approximately 1–2 months between the development of non-secretor and secretor HMO profiles was shown. The results highlighted the importance of long-term breastfeeding, especially among non-secretors.

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“…Breastfeeding has long been recognized as the gold standard for infant care, which provides health benefits to both the mother and the infant. Breastfeeding is associated with a reduced risk of breast cancer, ovarian cancer, and type 2 diabetes in mothers, as well as a reduced risk of acute illness and gastrointestinal problems in infants [ 6 , 7 ]. It has been shown that breastfeeding has long-term benefits that lower the rate of obesity and predict better health and cognitive development later in life [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

The Associations of Breastfeeding and Postnatal Experiences With Postpartum Depression Among Mothers of Hospitalized Infants in Tertiary Hospitals

Shukri¹,

Senjaya²,

Zainudin³

et al. 2022

Cureus

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BackgroundPostpartum depression has been linked to undesirable outcomes for mother-infant dyads, interfering with childcare and breastfeeding practices. This study aimed to determine the prevalence of depressive symptoms among mothers during the postpartum period and its association with breastfeeding and postpartum experiences. MethodologyThis cross-sectional study involved mothers of hospitalized infants (n = 219) at two tertiary hospitals in Klang Valley, Malaysia. Mothers were screened for postpartum depression using the Edinburgh Postnatal Depression Scale with a cut-off of ≥12 for positive screening for depression. Mothers were asked to complete questionnaires on breastfeeding experience, which included breastfeeding self-efficacy and challenges. The questionnaires also collected information on postnatal experiences, including birth outcomes, anxiety and stress levels, and social support. Multiple linear regression was used to ascertain the association of postpartum depression levels with breastfeeding and postnatal experiences. ResultsOverall, 30% of mothers in this study screened positive for depression. Based on multiple linear regression, a higher score of postpartum depression was significantly associated with unpleasant breastfeeding and postnatal experiences reflected by increased scores of anxiety and stress, lower infant birth weight, increased breastfeeding problems, and lower level of social support (p < 0.005). ConclusionsMaternal emotions, birth outcomes, breastfeeding issues, and social support were associated with postpartum depression. Efforts should be made to increase maternal support, and screening for maternal depression during infant hospital stays should be encouraged.

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Human milk: From complex tailored nutrition to bioactive impact on child cognition and behavior

Cited by 33 publications

References 466 publications

Human Milk Extracellular Vesicles: A Biological System with Clinical Implications

Human Milk Extracellular Vesicles: A Biological System with Clinical Implications

1H NMR Metabolomics of Chinese Human Milk at Different Stages of Lactation among Secretors and Non-Secretors

The Associations of Breastfeeding and Postnatal Experiences With Postpartum Depression Among Mothers of Hospitalized Infants in Tertiary Hospitals

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