Human milk oligosaccharides in breast milk and 2-year outcome in preterm infants: An exploratory analysis

Rozé, Jean‐Christophe; Hartweg, Mickaël; Simon, Laure; Billard, Hélène; Chen, Yipu; Austin, Sean; Boscher, Cécile; Moyon, Thomas; Rodenas, Clara L. Garcia; Boquien, Clair‐Yves

doi:10.1016/j.clnu.2022.07.024

Cited by 13 publications

(45 citation statements)

References 51 publications

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“…Further, relationships are likely to vary depending on whether HMO concentration or intake is measured [ 45 , 59 ]. Intake of 3′SL at 2 months of age has been positively associated with infant weight, length, and fat-free mass, which is consistent with studies measuring 3′SL concentrations [ 59 , 78 , 90 ]. However, results in relation to intake are not always consistent with that of the concentration.…”

Section: Human Milk Oligosaccharides (Hmos)supporting

confidence: 86%

Section: Human Milk Oligosaccharides (Hmos)mentioning

confidence: 99%

“…Multiple studies, although inconsistent, have identified various associations between individual HMOs and/or HMO diversity and infant growth [ 77 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 ]. Most of the previous studies have measured HMOs using high-performance liquid chromatography–mass spectrometry (HPLC-MS) in conjunction with fluorescent derivatisation [ 59 , 77 , 78 , 84 , 85 , 86 , 87 , 88 , 90 , 91 ], and two have used nano-LC-chip/time-of-flight (TOF)-MS [ 83 , 89 ]. However, differences in study populations and design, including sample time point(s) and reporting styles for infant growth data, make it difficult to identify any consensus between studies, with contradictory associations reported for some HMOs ( Table 1 ).…”

Section: Human Milk Oligosaccharides (Hmos)mentioning

confidence: 99%

“…Associations between infant anthropometrics and the most abundant HMO, 3′SL (3′ sialyllactose), are widely reported [ 59 , 77 , 78 , 83 , 86 , 87 , 89 , 90 ]. Concentrations of 3′SL have been positively associated with infant weight [ 89 ], length [ 77 ], head circumference [ 77 , 83 ], weight for length [ 88 ], fat mass [ 78 ], and fat-free mass [ 59 , 90 ], except in one study that reported a negative association with infant length [ 88 ]. This discrepancy may be due to the time at which infant anthropometrics were measured (birth to 4 months in one study, and 5 and 9 months in the other) [ 77 , 88 ].…”

Section: Human Milk Oligosaccharides (Hmos)mentioning

confidence: 99%

“…Maternal secretor status influences HMO composition, particularly 2′FL (2′ fucosyllactose) and LNnT (lacto-N-neotetraose), both of which have been added to commercial formulas [ 92 ]. 2′FL concentration has been positively associated with infant weight [ 77 , 87 ], length [ 89 , 90 ], and fat mass [ 77 ] in both healthy and malnourished populations. 2′FL intake also has been positively associated with weight and fat mass [ 59 ].…”

Section: Human Milk Oligosaccharides (Hmos)mentioning

confidence: 99%

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Human Milk Microbiome and Microbiome-Related Products: Potential Modulators of Infant Growth

Palmer

Geddes

et al. 2022

Nutrients

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Infant growth trajectory may influence later-life obesity. Human milk provides a wide range of nutritional and bioactive components that are vital for infant growth. Compared to formula-fed infants, breastfed infants are less likely to develop later-onset obesity, highlighting the potential role of bioactive components present in human milk. Components of particular interest are the human milk microbiota, human milk oligosaccharides (HMOs), short-chain fatty acids (SCFAs), and antimicrobial proteins, each of which influence the infant gut microbiome, which in turn has been associated with infant body composition. SCFAs and antimicrobial proteins from human milk may also systemically influence infant metabolism. Although inconsistent, multiple studies have reported associations between HMOs and infant growth, while studies on other bioactive components in relation to infant growth are sparse. Moreover, these microbiome-related components may interact with each other within the mammary gland. Here, we review the evidence around the impact of human milk microbes, HMOs, SCFAs, and antimicrobial proteins on infant growth. Breastfeeding is a unique window of opportunity to promote optimal infant growth, with aberrant growth trajectories potentially creating short- and long-term public health burdens. Therefore, it is important to understand how bioactive components of human milk influence infant growth.

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Section: Human Milk Oligosaccharides (Hmos)supporting

confidence: 86%

Section: Human Milk Oligosaccharides (Hmos)mentioning

confidence: 99%

Section: Human Milk Oligosaccharides (Hmos)mentioning

confidence: 99%

Section: Human Milk Oligosaccharides (Hmos)mentioning

confidence: 99%

Section: Human Milk Oligosaccharides (Hmos)mentioning

confidence: 99%

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Human Milk Microbiome and Microbiome-Related Products: Potential Modulators of Infant Growth

Palmer

Geddes

et al. 2022

Nutrients

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Importance of human milk for infants in the clinical setting: Updates and mechanistic links

Nagel,

Elgersma,

Gallagher

et al. 2023

Nut in Clin Prac

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IntroductionHuman milk (HM) is the optimal source of nutrition for infants and has been implicated in multiple aspects of infant health. Although much of the existing literature has focused on the individual components that drive its nutrition content, examining HM as a biological system is needed for meaningful advancement of the field. Investigation of the nonnutritive bioactive components of HM and the maternal, infant, and environmental factors which affect these bioactives is important to better understand the importance of HM provision to infants. This information may inform care of clinical populations or infants who are critically ill, hospitalized, or who have chronic diseases and may benefit most from receiving HM.MethodsIn this narrative review, we reviewed literature examining maternal and infant influences on HM composition with a focus on studies published in the last 10 years that were applicable to clinical populations.ResultsWe found multiple studies examining HM components implicated in infant immune and gut health and neurodevelopment. Additional work is needed to understand how donor milk and formula may be used in situations of inadequate maternal HM. Furthermore, a better understanding of how maternal factors such as maternal genetics and metabolic health influence milk composition is needed.ConclusionIn this review, we affirm the importance of HM for all infants, especially clinical populations. An understanding of how HM composition is modulated by maternal and environmental factors is important to progress the field forward with respect to mechanistic links between HM biology and infant health outcomes.

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Recent advances of 3-fucosyllactose in health effects and production

Du,

Li,

Guang

et al. 2024

Arch Microbiol

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Human milk oligosaccharides in breast milk and 2-year outcome in preterm infants: An exploratory analysis

Cited by 13 publications

References 51 publications

Human Milk Microbiome and Microbiome-Related Products: Potential Modulators of Infant Growth

Human Milk Microbiome and Microbiome-Related Products: Potential Modulators of Infant Growth

Importance of human milk for infants in the clinical setting: Updates and mechanistic links

Recent advances of 3-fucosyllactose in health effects and production

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