2017
DOI: 10.1074/jbc.m117.789974
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Human milk oligosaccharides inhibit growth of group B Streptococcus

Abstract: (group B , GBS) is a leading cause of invasive bacterial infections in newborns, typically acquired vertically during childbirth secondary to maternal vaginal colonization. Human milk oligosaccharides (HMOs) have important nutritional and biological activities that guide the development of the immune system of the infant and shape the composition of normal gut microbiota. In this manner, HMOs help protect against pathogen colonization and reduce the risk of infection. In the course of our studies of HMO-microb… Show more

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Cited by 139 publications
(127 citation statements)
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“…Comments on the patient recruitment and classification into groups of high and low risk for preterm birth Our study was originally designed to compare women with confirmed preterm labor (weeks [23][24][25][26][27][28][29][30][31][32][33][34] with gestational matched controls without contractions with regards to microbiome, HMOs and metabolites. We originally formed the groups of cases and controls (Fig.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Comments on the patient recruitment and classification into groups of high and low risk for preterm birth Our study was originally designed to compare women with confirmed preterm labor (weeks [23][24][25][26][27][28][29][30][31][32][33][34] with gestational matched controls without contractions with regards to microbiome, HMOs and metabolites. We originally formed the groups of cases and controls (Fig.…”
Section: Methodsmentioning
confidence: 99%
“…HMOs were found to serve as substrates for specific strains of genera such as Bifidobacterium and Bacteroides [21,22], and Lactobacillus [23,24]. Besides their prebiotic activities towards beneficial microbes, HMOs can also directly act on microbes as anti-adhesives [25][26][27][28] or antimicrobials [29].…”
mentioning
confidence: 99%
“…LNnT has been shown to reduce the number of Streptococcus pneumonia cells in the lungs of an animal model [7]. There is a unique antibacterial role for HMOs against the leading neonatal pathogen Streptococcus B. HMOs may act as a substrate to modify growth of these bacteria [23]. The anti-adhesive properties of HMOs also apply to some parasitic protozoa, e.g., Entamoeba histolytica, which cause amoebic dysentery or amoebic liver abscess.…”
Section: Prevention Of Pathogen Adhesionmentioning
confidence: 99%
“…Future research can help identify the relationships of individual HMOs, such as LNT, with the risk of GBS infection. The development of new anti-infective strategies based on the natural standard of human milk seems likely [23].…”
Section: New Possibilities Of Hmo Applicationsmentioning
confidence: 99%
“…While the Bode laboratory has evidence which suggests that HMOs may serve as alternative substrates capable of impairing growth kinetics, a definitive mechanism of inhibition has yet to be determined. 57,58 …”
Section: Hmo-mediated Pathogen Protectionmentioning
confidence: 99%