Human monoclonal antibodies: A tool for cancer detection <i>in vivo</i>

Ditzel, Henrik J.

doi:10.1111/j.1600-0463.1999.tb05692.x

APMIS

1999

DOI: 10.1111/j.1600-0463.1999.tb05692.x

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Human monoclonal antibodies: A tool for cancer detection in vivo

Henrik J. Ditzel

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2000

2023

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Cited by 2 publications

References 196 publications

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Human Antibodies in Cancer and Autoimmune Disease

Ditzel

2000

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In recent years, a number of novel human autoantigens and tumor-associated antigens have been identified using patient sera. Several of these antigens have been used as diagnostic markers, but defining their role in disease pathogenesis has been hampered by the lack of cloned human antibodies and antigens. Focusing on the solid cancers of the breast and colon and on autoimmune hematologic diseases, we are studying the role of human antibodies in disease pathogenesis. We have generated several human monoclonal autoimmune and cancer-associated antibodies, using antibody phage display technology, and have identified, cloned, and expressed their corresponding (novel) antigens. Using the monoclonal human antibodies as probes, we are elucidating the processes that lead to the generation of these antibodies and their possible pathogenic or protective effect. These studies may lead to the development of reagents for diagnosis and therapeutic intervention of these important diseases.

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Human Antibodies in Cancer and Autoimmune Disease

Ditzel

2000

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Improved Radioimmunodetection of Carcinomas with a Re-injection of Monoclonal Antibodies after Formation of Anti-mouse Antibodies

Werner

Coveñas

2023

CPD

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Scintigraphic imaging was satisfactory in animal experiments, i.e., in the radioimmunodetection with 125J anti-tissue polypeptide antigen monoclonal antibodies and implanted HELA cell carcinomas. Unlabeled anti-mouse antibodies (AMAB), in a surplus of 40:1, 200:1 and 4000:1 compared to the radioactive antibody, were administered five days after administering the 125I anti-TPA antibody (RAAB). In immunoscintigraphies, radioactivity accumulated in the liver immediately after administering the secondary antibody, and the tumor's imaging worsened. It can be expected that imunoscintigraphic imaging might improve when radioimmunodetection is re-performed after the formation of human anti-mouse antibodies (AMAB) and when the ratio of the primary to the secondary antibody is nearly equivalent because, in this ratio, the formation of immune complexes might be accelerated. It is possible to measure the quantity of formed anti-mouse antibodies (AMAB) with immunography measurements. A second administration of diagnostic or therapeutic monoclonal antibodies might lead to the formation of immune complexes if the quantities of the monoclonal antibodies and the anti-mouse antibodies have an equivalent ratio. A second performance of the radioimmunodetection four to eight weeks after the first radioimmunodetection can achieve better tumor imaging because human anti-mouse antibodies (AMAB) can be formed. Immune complexes of the radioactive antibody and the human anti-mouse antibody (AMAB) can be formed to concentrate radioactivity in the tumor

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Human monoclonal antibodies: A tool for cancer detection in vivo

Cited by 2 publications

References 196 publications

Human Antibodies in Cancer and Autoimmune Disease

Human Antibodies in Cancer and Autoimmune Disease

Improved Radioimmunodetection of Carcinomas with a Re-injection of Monoclonal Antibodies after Formation of Anti-mouse Antibodies

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