Human monoclonal antibodies protect against viral-mediated pneumococcal superinfection
Aaron Gingerich,
Lauren Mahoney,
Anna L. McCormick
et al.
Abstract:IntroductionCommunity-acquired pneumonia (CAP) is a global health concern, with 25% of cases attributed to Streptococcus pneumoniae (Spn). Viral infections like influenza A virus (IAV), respiratory syncytial virus (RSV), and human metapneumovirus (hMPV) increase the risk of Spn, leading to severe complications due to compromised host immunity.MethodsWe evaluated the efficacy of an anti-PhtD monoclonal antibody (mAb) cocktail therapy (PhtD3 + 7) in improving survival rates in three viral/bacterial coinfection m… Show more
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