1997
DOI: 10.1542/peds.100.1.e10
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Human Monocytic Ehrlichiosis in Children

Abstract: ABSTRACT. Background. Much of what is known about human monocytic ehrlichiosis (HME) is based upon studies with adult patients.Purpose. To review our experience with HME to better understand the epidemiology, clinical manifestations, and outcome of this disease in children.Methods. Demographic, clinical, and laboratory data were gathered after review of the medical records of patients identified with HME.Results. Twelve patients with an median age of 7.4 years (range, 7 months to 13.7 years) were identified wi… Show more

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Cited by 58 publications
(21 citation statements)
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“…Renal failure, previously reported in 6% of adults with ehrlichiosis [6], has only recently been described in children [7]. Children with BUN >36 mg/dl are at higher risk of severe renal disease [5], as was the case in our patient. Although nephrotic syndrome has not been described as a complication of human ehrlichiosis, dogs inoculated with E. canis develop proteinuria in the nephrotic range during the acute phase of the infection [8].…”
Section: Discussionsupporting
confidence: 68%
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“…Renal failure, previously reported in 6% of adults with ehrlichiosis [6], has only recently been described in children [7]. Children with BUN >36 mg/dl are at higher risk of severe renal disease [5], as was the case in our patient. Although nephrotic syndrome has not been described as a complication of human ehrlichiosis, dogs inoculated with E. canis develop proteinuria in the nephrotic range during the acute phase of the infection [8].…”
Section: Discussionsupporting
confidence: 68%
“…Renal abnormalities with serum elevations of BUN and creatinine, proteinuria, or hematuria have been described [2,5]. Renal failure, previously reported in 6% of adults with ehrlichiosis [6], has only recently been described in children [7].…”
Section: Discussionmentioning
confidence: 99%
“…Laboratory abnormalities, however, are more pronounced in children with ehrlichiosis: thrombocytopenia is present in more than 90%, as are elevations of hepatic transaminases; leukopenia (<4000/mm 3 ) occurs in about 60% of patients. 1,11,12,15 Anaplasmosis Patients with anaplasmosis present with signs, symptoms, and laboratory findings similar to those observed in ehrlichiosis, with the notable exception that rash is present in fewer than 10% of patients with anaplasmosis. 1,3…”
Section: Ehrlichiosismentioning
confidence: 83%
“…At least one-third of all patients with serologically diagnosed RMSF or ehrlichiosis do not recall a preceding tick bite. 1,[11][12][13] Risk Factors…”
Section: Exposure Historymentioning
confidence: 99%
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