Human–mouse comparison of the multistage nature of radiation carcinogenesis in a mathematical model
Tatsuhiko Imaoka,
Satoshi Tanaka,
Masanori Tomita
et al.
Abstract:Mouse models are vital for assessing risk from environmental carcinogens, including ionizing radiation, yet the interspecies difference in the dose response precludes direct application of experimental evidence to humans. Herein, we take a mathematical approach to delineate the mechanism underlying the human–mouse difference in radiation‐related cancer risk. We used a multistage carcinogenesis model assuming a mutational action of radiation to analyze previous data on cancer mortality in the Japanese atomic bo… Show more
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