“…The Mps1 family of kinases has been described in several other species including mouse (esk/mMps1; Douville et al, 1992), S. cerevisiae (Mps1p; Winey et al, 1991), S. pombe (Mph1p; He et al, 1998), Xenopus laevis (xMps1; Abrieu et al, 2001), zebrafish (mps1/ncp; Poss et al, 2002) and Drosophila (Mps1; Fischer et al, 2004). In budding yeast (S. cerevisiae), this kinase is required for spindle pole duplication and spindle assembly checkpoint, whereas in mammals, although involved in spindle checkpoint, the kinase is thought to be involved in centrosome duplication, although this is debated (Weiss and Winey, 1996;Fisk and Winey, 2001; Stucke et al, 2002;Fisk et al, 2003). During mitosis, Mps1 localizes to kinetochores and is required for proper chromosome alignment and segregation as well as the recruitment of other mitotic checkpoint proteins in the event of unattached chromosome or uneven tension at the kinetochores (Abrieu et al, 2001;Stucke et al, 2004;Vigneron et al, 2004;Jelluma et al, 2008).…”