Human Muse cells-derived neural precursor cells as the novel seed cells for the repair of spinal cord injury

Chen, Xue; Yin, Xinyao; Zhao, Yayu; Wang, Chen-Chun; Du, Pan; Lu, Yichi; Jin, Hongbo; Yang, Chengcheng; Ying, Jia-Lu

doi:10.1016/j.bbrc.2021.06.070

Cited by 10 publications

(8 citation statements)

References 23 publications

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“…The efficiency of SSEA-3+ cells was confirmed also in vivo in multiple animal models [ 52 , 68 – 72 ]. SSEA-3+-MUSE cells integrated into a host tissue and differentiated into neural cells after transplantation, which facilitated neural reconstruction in an animal model of lacunar stroke [ 72 ].…”

Section: Markers For Stem Population Within Mscsmentioning

confidence: 85%

“…SSEA-3+-MUSE cells formed spheroids that were self-renewal and exhibited pluripotency—differentiated toward cells from all three germ layers upon in vitro culture and after in vivo transplantation [ 21 , 42 , 43 , 66 ]. SSEA-3+ cells were confirmed to differentiate in vitro toward cells from different germ layers, such as insulin-producing cells or neural precursor cells [ 67 , 68 ]. Blocking SSEA-3 in the MUSE population reduced proliferation, clonogenicity, expression of pluripotent genes SOX2 and OCT3/4, as well as differentiation toward cells from three germ layers [ 66 ].…”

Section: Markers For Stem Population Within Mscsmentioning

confidence: 99%

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Promising Markers in the Context of Mesenchymal Stem/Stromal Cells Subpopulations with Unique Properties

Smolinska,

Bzinkowska,

Rybkowska

et al. 2023

Stem Cells International

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The heterogeneity of the mesenchymal stem/stromal cells (MSCs) population poses a challenge to researchers and clinicians, especially those observed at the population level. What is more, the lack of precise evidences regarding MSCs developmental origin even further complicate this issue. As the available evidences indicate several possible pathways of MSCs formation, this diverse origin may be reflected in the unique subsets of cells found within the MSCs population. Such populations differ in specialization degree, proliferation, and immunomodulatory properties or exhibit other additional properties such as increased angiogenesis capacity. In this review article, we attempted to identify such outstanding populations according to the specific surface antigens or intracellular markers. Described groups were characterized depending on their specialization and potential therapeutic application. The reports presented here cover a wide variety of properties found in the recent literature, which is quite scarce for many candidates mentioned in this article. Even though the collected information would allow for better targeting of specific subpopulations in regenerative medicine to increase the effectiveness of MSC-based therapies.

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Section: Markers For Stem Population Within Mscsmentioning

confidence: 85%

Section: Markers For Stem Population Within Mscsmentioning

confidence: 99%

Promising Markers in the Context of Mesenchymal Stem/Stromal Cells Subpopulations with Unique Properties

Smolinska,

Bzinkowska,

Rybkowska

et al. 2023

Stem Cells International

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“…To date, Muse cells have been used in neurological diseases [63,66,[107][108][109][110][111][112], cardiac systemic diseases [39,49,55,75,[113][114][115][116], renal diseases [40,99,117], dermatological diseases [44,78,[118][119][120], liver diseases [29,41,67,101,121], and other diseases to demonstrate their desirable effects in treating and repairing damaged tissues. In these disease models, Muse cells can migrate to the lesion site and spontaneously differentiate into histocompatible cells such as neurons (ectoderm) [43,111,122], cardiomyocytes (mesoderm) [115,123], glomerulocytes (mesoderm) [40,117], vascular endothelial cells (mesoderm) [34,120]and hepatocytes (entoderm) [41,101,121].…”

Section: The Regenerative Potential Of Muse Cells Has Been Confirmedmentioning

confidence: 99%

Multilineage-Differentiating Stress-Enduring Cells: A Powerful Tool for Tissue Damage Repair

Que,

Mai,

et al. 2024

Preprint

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Multilineage-differentiating stress-enduring (Muse) cells, a cell subgroup from mesenchymal stem cells (MSCs), are pluripotent cells with unique characteristics such as non-tumorigenic and pluripotent differentiation ability. After homing, Muse cells spontaneously differentiate into tissue component cells and supplement damaged/lost cells to participate in tissue repair. Importantly, Muse cells can survive in injured tissue for an extended period, stabilizing and promoting tissue repair. In addition, it has been confirmed that injection of exogenous Muse cells exerts anti-inflammatory, anti-apoptosis, anti-fibrosis, immunomodulatory, and paracrine protective effects in vivo. The discovery of Muse cells is an important breakthrough in regenerative medicine. The article provides a comprehensive review of the characteristics, sources, and potential mechanisms of Muse cells for tissue repair and regeneration. This review serves as a foundation for the further utilization of Muse cells as a key clinical tool in regenerative medicine.

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“…The low survival rate of MSCs after transplantation in SCI is the main cause of not using MSC in treating SCI. In addition to the low survival rates MSCs also have a low ability to differentiate neuron lineages [ 52 ].…”

Section: Therapeutic Applications Of Muse Cellsmentioning

confidence: 99%

“…Muse-NPCs have the features of neural stem cells since they can differentiate into oligodendrocytes, neurons, and astrocytes. Most significantly, Muse-NPCs had a greater differentiation rate and more noticeable benefits in biological activities when compared to BMSCs and Muse cells [ 52 ] ( Table 3 ).…”

Section: Therapeutic Applications Of Muse Cellsmentioning

confidence: 99%

Multilineage Differentiating Stress Enduring (Muse) Cells: A New Era of Stem Cell-Based Therapy

Alanazi,

Alhwity,

Almahlawi

et al. 2023

Cells

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Stem cell transplantation has recently demonstrated a significant therapeutic efficacy in various diseases. Multilineage-differentiating stress-enduring (Muse) cells are stress-tolerant endogenous pluripotent stem cells that were first reported in 2010. Muse cells can be found in the peripheral blood, bone marrow and connective tissue of nearly all body organs. Under basal conditions, they constantly move from the bone marrow to peripheral blood to supply various body organs. However, this rate greatly changes even within the same individual based on physical status and the presence of injury or illness. Muse cells can differentiate into all three-germ-layers, producing tissue-compatible cells with few errors, minimal immune rejection and without forming teratomas. They can also endure hostile environments, supporting their survival in damaged/injured tissues. Additionally, Muse cells express receptors for sphingosine-1-phosphate (S1P), which is a protein produced by damaged/injured tissues. Through the S1P–S1PR2 axis, circulating Muse cells can preferentially migrate to damaged sites following transplantation. In addition, Muse cells possess a unique immune privilege system, facilitating their use without the need for long-term immunosuppressant treatment or human leucocyte antigen matching. Moreover, they exhibit anti-inflammatory, anti-apoptotic and tissue-protective effects. These characteristics circumvent all challenges experienced with mesenchymal stem cells and induced pluripotent stem cells and encourage the wide application of Muse cells in clinical practice. Indeed, Muse cells have the potential to break through the limitations of current cell-based therapies, and many clinical trials have been conducted, applying intravenously administered Muse cells in stroke, myocardial infarction, neurological disorders and acute respiratory distress syndrome (ARDS) related to novel coronavirus (SARS-CoV-2) infection. Herein, we aim to highlight the unique biological properties of Muse cells and to elucidate the advantageous difference between Muse cells and other types of stem cells. Finally, we shed light on their current therapeutic applications and the major obstacles to their clinical implementation from laboratory to clinic.

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Human Muse cells-derived neural precursor cells as the novel seed cells for the repair of spinal cord injury

Cited by 10 publications

References 23 publications

Promising Markers in the Context of Mesenchymal Stem/Stromal Cells Subpopulations with Unique Properties

Promising Markers in the Context of Mesenchymal Stem/Stromal Cells Subpopulations with Unique Properties

Multilineage-Differentiating Stress-Enduring Cells: A Powerful Tool for Tissue Damage Repair

Multilineage Differentiating Stress Enduring (Muse) Cells: A New Era of Stem Cell-Based Therapy

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