Human Mycobacterium bovis infection in Castile and León (Spain), 2006–2015

Nebreda-Mayoral, Teresa; Brezmes-Valdivieso, M. Fé; Gutiérrez-Zufiaurre, Nieves; Cruz, Susana García-de; Labayru-Echeverría, Cristina; López-Medrano, Ramiro; López-Urrutia-Lorente, Luis; Tinajas-Puertas, Almudena; Rivero-Lezcano, Octavio Miguel

doi:10.1016/j.eimce.2018.10.001

Cited by 4 publications

(4 citation statements)

References 17 publications

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“…In contrast, a previous study reported absence of polyresistant M. bovis strains isolated from livestock in the Iberian Peninsula (7). Similarly, cases of TB in humans caused by isoniazid-resistant M. bovis are infrequent in Spain (8), although a nosocomial outbreak caused by MDR M. bovis involving HIV-infected patients has been described (9). Only a few studies have examined treatment of isoniazid polydrug resistance (10), which is particularly dangerous because of the high risk that resistance to rifampin will develop, requiring full MDR TB treatment.…”

Section: Research Lettersmentioning

confidence: 78%

Polyresistant Mycobacterium bovis Infection in Human and Sympatric Sheep, Spain, 2017–2018

Val¹,

Romero²,

Tórtola³

et al. 2021

Emerg. Infect. Dis.

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The main etiologic agent of tuberculosis (TB) in livestock is Mycobacterium bovis ; human TB cases caused by M. bovis are rare. Analysis of a TB outbreak caused by polyresistant M. bovis involving a human and sympatric sheep in Spain suggests local circulation of drug-resistant M. bovis strains among livestock.

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Section: Research Lettersmentioning

confidence: 78%

Polyresistant Mycobacterium bovis Infection in Human and Sympatric Sheep, Spain, 2017–2018

Val¹,

Romero²,

Tórtola³

et al. 2021

Emerg. Infect. Dis.

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“…bovis (United Kingdom) [ 19 ]. In addition, surveillance data were used as a source of information for scientific research (Australia, France, United States, New Zealand, United Kingdom, The Netherlands, Mexico, Italy, and Spain) [ 13 , 15 – 17 , 19 , 23 – 30 ].…”

Section: Resultsmentioning

confidence: 99%

One Health and surveillance of zoonotic tuberculosis in selected low-income, middle-income and high-income countries: A systematic review

et al. 2022

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Background Little is known about zoonotic tuberculosis (zTB) due to Mycobacterium bovis burden across the globe. The aim of this study was to describe zTB surveillance programs in selected WHO signatory countries and to assess the relationship of the disease with the country’s income level and the risk of M. bovis transmission. Methods We searched the main articles databases and grey literature for guide documents published between 1980 and 2019. For inclusion, the articles and guide documents had to be in English, French, Portuguese, Spanish, or Italian. Only original articles and narrative and systematic reviews were accepted and the guide documents were required to be available on official websites. We excluded articles that did not focus on epidemiology, control and surveillance. We used bovine TB cases in livestock and wildlife populations as a proxy for the country’s risk of zTB using data from the World Organization for Animal Health (OIE) published from 2015 to 2018. Countries were classified according to income level (World Bank’s classification) and strength of zTB surveillance. The study was registered in PROSPERO under number CRD42018090603. Findings We included 13 articles and 208 guide documents including data from 119/194 countries (61.3%). We found a lack of surveillance data about zTB in over half (89.9%) of the 119 WHO signatory countries. Most surveillance systems perform passive surveillance and are not integrated into the One Health perspective, which was operating in 4/119 (3.4%) countries, all high-income. Many of these countries (71/119, 59.7%) have M. bovis circulating in their cattle herds, but only ~10% of them have implemented zTB surveillance activities. Interpretation Our findings highlight weaknesses in zTB surveillance worldwide, with a consequent lack of information that could support an adequate understanding of disease burden, especially in countries at major risk for M. bovis transmission. To meet this challenge, efforts will be needed to promote intersectoral policies, implementing the One Health strategy.

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“…Bovine tuberculosis is a chronic, deadly infection most often caused by Mycobacterium bovis (M. bovis) and Mycobacterium caprae (M. caprae), two species belonging to the Mycobacterium tuberculosis complex [1,2]. M. bovis most often infects cattle but also causes tuberculosis in other animal species and is a re-emerging cause of zoonotic tuberculosis in humans [3,4]. This disease poses a major threat to public health and creates socioeconomic problems, including loss of meat due to seizures in slaughterhouses and lower milk yields [5,6].…”

Section: Introductionmentioning

confidence: 99%

Whole Genome Sequence Analysis of Mycobacterium bovis Cattle Isolates, Algeria

et al. 2021

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Mycobacterium bovis (M. bovis), a Mycobacterium tuberculosis complex species responsible for tuberculosis in cattle and zoonotic tuberculosis in humans, is present in Algeria. In Algeria however, the M. bovis population structure is unknown, limiting understanding of the sources and transmission of bovine tuberculosis. In this study, we identified the whole genome sequence (WGS) of 13 M. bovis strains isolated from animals exhibiting lesions compatible with tuberculosis, which were slaughtered and inspected in five slaughterhouses in Algeria. We found that six isolates were grouped together with reference clinical strains of M. bovis genotype-Unknown2. One isolate was related to M. bovis genotype-Unknown7, one isolate was related to M. bovis genotype-Unknown4, three isolates belonged to M. bovis genotype-Europe 2 and there was one new clone for two M. bovis isolates. Two isolates from Blida exhibited no pairwise differences in single nucleotide polymorphisms. None of these 13 isolates were closely related to four zoonotic M. bovis isolates previously characterized in Algeria. In Algeria, the epidemiology of bovine tuberculosis in cattle is partly driven by cross border movements of animals and animal products.

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Human Mycobacterium bovis infection in Castile and León (Spain), 2006–2015

Cited by 4 publications

References 17 publications

Polyresistant Mycobacterium bovis Infection in Human and Sympatric Sheep, Spain, 2017–2018

Polyresistant Mycobacterium bovis Infection in Human and Sympatric Sheep, Spain, 2017–2018

One Health and surveillance of zoonotic tuberculosis in selected low-income, middle-income and high-income countries: A systematic review

Whole Genome Sequence Analysis of Mycobacterium bovis Cattle Isolates, Algeria

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