Human Mycobacterium bovis infection in ten Latin American countries

Tuberculosis patients co-infected with Mycobacterium bovis and Mycobacterium tuberculosis in an urban area of Brazil

“…The proportion of M. bovis in this study (1.6%) was slightly lower than the 3.5% reported in a previous Brazilian study (Corrêa & Corrêa 1974), but higher than those reported in recent Brazilian studies that either could not find any profiles of M. bovis or found a much lower prevalence (de Kantor et al 2008). These recent findings ), including our own data, suggests that the importance of M. bovis in the global burden of PTB in Brazil is marginal .…”

“…In Latin America, the estimated proportion of zoonotic TB that is caused by M. bovis accounts for 2% and 8% of pulmonary (PTB) and extrapulmonary (EPTB) TB cases, respectively (Cosivi et al 1998, de Kantor et al 2008. In Brazil, a more representative study found that the proportion of zoonotic cases due to M. bovis was estimated to be 3.5% of all TB cases (Corrêa & Corrêa 1974).…”

“…The best estimate of the prevalence of zoonotic TB due to M. bovis in humans in Argentina, Brazil, Chile, Colombia, Costa Rica, Dominican Republic, Ecuador, Peru, Uruguay and Venezuela was published in (de Kantor et al 2008. In Chile, Colombia, Costa Rica, the Dominican Republic, Peru and Uruguay, M. bovis was most likely never isolated from humans and only four of these countries reported bacteriologically confirmed cases of M. bovis infection in humans.…”

“…Most of these cases were diagnosed in Argentina, where the mean prevalence of M. bovis cases in relation to those due to M. tuberculosis (2000)(2001)(2002)(2003)(2004)(2005)(2006) ranged from 0.34-1%, according to region. In most of these 10 countries, the low coverage of M. bovis-appropriate culture methods, including pyruvate-containing media, likely contributes to the underestimation of this infection (de Kantor et al 2008).…”

Avaliação da virulência micobacteriana e modulação da resposta imune durante a infecção por isolados clínicos de Mycobacterium bovis e Mycobacterium tuberculosis.

“…Estima-se que ela tenha sido responsável por cerca de 10-18% de todos os casos de tuberculose, existindo uma associação entre o número de casos humanos identificados e a prevalência da tuberculose na população bovina local (Abrahão, 1999 (Grange, 2001;Rua-Domenech, 2006;de Kantor et al, 2008;Rodriguez et al, 2010). Além disso, a transmissão do bacilo bovino de humano para humano também tem sido notificada (Torgerson, 2008;Shrikrishna et al, 2009 (Cosivi et al, 1998;Ayele et al, 2004 (Ayele et al, 2004).…”