Human nasal mucosa ectomesenchymal stem cells derived extracellular vesicles loaded omentum/chitosan composite scaffolds enhance skull defects regeneration

Shi, Wentao; Gao, Yan; Wu, Yiqing; Tang, Yushi; Bian, Lu; Que, Yunduan; Liu, Long; Bai, Xu; Tang, Hong; Lu, Xiaojie; Wang, Qing

doi:10.1016/j.ijbiomac.2023.125924

Cited by 1 publication

(4 citation statements)

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Section: Alginatementioning

confidence: 99%

“…In vivo experiments showed that a large amount of new bone formation occurred at the injured site eight weeks after implantation (Figure 4E). [111] After an indepth exploration of the mechanism of action, they observed that EVs derived from human nasal mucosa MSCs with high retention and sustained release significantly enhanced the activity of TG2, the extracellular matrix signaling pathway, facilitating the osteogenic differentiation of suture MSCs. [111] Researchers have discovered that chitosan-based delivery platforms can play a crucial role in cartilage repair.…”

Section: Chitosanmentioning

confidence: 99%

“…[111] After an indepth exploration of the mechanism of action, they observed that EVs derived from human nasal mucosa MSCs with high retention and sustained release significantly enhanced the activity of TG2, the extracellular matrix signaling pathway, facilitating the osteogenic differentiation of suture MSCs. [111] Researchers have discovered that chitosan-based delivery platforms can play a crucial role in cartilage repair. In addressing this non-self-healing tissue, Li et al used chitosan to couple EVs derived from adiposederived MSCs to reverse the expression induced by cartilage injury.…”

Section: Chitosanmentioning

confidence: 99%

mentioning

confidence: 99%

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Extracellular Vesicles in the Repair of Bone and Cartilage Injury: From Macro‐Delivery to Micro‐Modification

Xu,

Li,

et al. 2024

Advanced Therapeutics

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Extracellular vesicles (EVs) are intermediaries in intercellular signal transmission and material exchange and have attracted significant attention from researchers in bone and cartilage repair. These nanoscale vesicles hold immense potential in facilitating bone and cartilage repair and regeneration by regulating the microenvironment at an injury site. However, their in vivo utilization is limited by their self‐clearance and random distribution. Therefore, various delivery platforms have been developed to improve EV targeting and retention rates in target organs while achieving a controlled release of EVs. Additionally, engineering modification of EVs has been proposed to effectively enhance EVs' intrinsic targeting and drug‐loading abilities and further improve their therapeutic effects on bone and cartilage injuries. This review aims to introduce the biogenesis of EVs and their regulatory mechanisms in the microenvironment of bone and cartilage injuries and comprehensively discuss the application of EV‐delivery platforms of different materials and various EV engineering modification methods in treating bone and cartilage injuries. The review's findings could help advance EV research and develop new strategies for improving the therapy of bone and cartilage injuries.This article is protected by copyright. All rights reserved

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Section: Alginatementioning

confidence: 99%

Section: Chitosanmentioning

confidence: 99%