2020
DOI: 10.1101/2020.08.11.245985
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Human neonatal B cell immunity differs from the adult version by conserved Ig repertoires and rapid, but transient response dynamics

Abstract: SUMMARYThe human infant B cell system is considered premature or impaired. Here we show that neonates have mature and fully functional B cell subsets as seen in adults, albeit with distinct transcriptional programs providing accelerated responsiveness to T cell independent and T cell dependent stimulation and facilitated IgA class switching. Stimulation drives extensive differentiation into antibody secreting cells, thereby presumably limiting memory B cell formation. The neonatal Ig-repertoire is highly varia… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

1
3
0

Year Published

2021
2021
2021
2021

Publication Types

Select...
3

Relationship

1
2

Authors

Journals

citations
Cited by 3 publications
(4 citation statements)
references
References 86 publications
1
3
0
Order By: Relevance
“…Although our data lacked evidence for a specific selection or molecular distinctness of the human sMZ B cell subset, we calculated the enrichment of shared clonotypes (identical IGHV gene and at least 90% CDRIII amino acid identity in multiple donors) in our cohort. Such clonotypes were overall very rare, and most frequent in neonates and children <4 yr of age, in line with our previous observations ( Budeus et al, 2020 Preprint ). A marginal enrichment of IGHV-mutated clonotypes is detectable in young adults ( Fig.…”
Section: Resultssupporting
confidence: 91%
See 1 more Smart Citation
“…Although our data lacked evidence for a specific selection or molecular distinctness of the human sMZ B cell subset, we calculated the enrichment of shared clonotypes (identical IGHV gene and at least 90% CDRIII amino acid identity in multiple donors) in our cohort. Such clonotypes were overall very rare, and most frequent in neonates and children <4 yr of age, in line with our previous observations ( Budeus et al, 2020 Preprint ). A marginal enrichment of IGHV-mutated clonotypes is detectable in young adults ( Fig.…”
Section: Resultssupporting
confidence: 91%
“…(G) Clonotype frequency among all sequences from 15 donors with at least four available B cell subsets. Neonatal-derived clonotypes were retrieved from Budeus et al, and MBC-derived clonotypes were retrieved from Ig mutated sequences of class-switched B cells ( Budeus et al, 2020 Preprint ). The curve links the data points (gray area represents the 95% CI of the smoothed conditional means with loess fitting).…”
Section: Resultsmentioning
confidence: 99%
“…Vaginal swabs for these organisms, as well as for oncogenic human papilloma virus types, should be carried out at the same time. Repeat serology testing for human immunodeficiency virus and hepatitis B and C in the second and third trimesters may potentially provide the opportunity to prevent mother–child transmission 31 …”
Section: When To Investigate Urgentlymentioning
confidence: 99%
“…In young infants, deficits are evident at multiple steps in this process. With that noted, there is some debate regarding the relative contributions of inherent B cell dysfunction versus the influence exerted by accessory immune cells to the altered nature of the neonatal B cell response [ 12 , 38 , 39 , 40 , 41 ]. B cells from newborns and young infants display several unique qualities not seen in mature, immunocompetent humoral responses.…”
Section: The Antibody Response Of Young Infantsmentioning
confidence: 99%