Human neural stem cells in patients with chronic ischaemic stroke (PISCES): a phase 1, first-in-man study

Kalladka, Dheeraj; Sinden, John D.; Pollock, Kenneth H.; Haig, Caroline; McLean, John M.; Smith, W. G. J.; McConnachie, Alex; Santosh, Celestine; Bath, Philip M; Dunn, Lee; Muir, Keith W.

doi:10.1016/s0140-6736(16)30513-x

Cited by 359 publications

(351 citation statements)

References 32 publications

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“…Preliminary studies using stem cells in stroke patients have also produced encouraging results with respect to both safety and tolerability of the treatment, as well as some promising improvements in motor functioning (Kalladka et al, 2016;Steinberg et al, 2016). Whether such improvements are related to the intervention or to spontaneous recovery still needs to be fully evaluated in larger, randomized clinical trials.…”

Section: Future Possibilitiesmentioning

confidence: 99%

What Do Language Disorders Reveal about Brain–Language Relationships? From Classic Models to Network Approaches

Dronkers

Ivanova

Baldo

2017

J Int Neuropsychol Soc

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Studies of language disorders have shaped our understanding of brain-language relationships over the last two centuries. This article provides a review of this research and how our thinking has changed over the years regarding how the brain processes language. In the 19th century, a series of famous case studies linked distinct speech and language functions to specific portions of the left hemisphere of the brain, regions that later came to be known as Broca's and Wernicke's areas. One hundred years later, the emergence of new brain imaging tools allowed for the visualization of brain injuries in vivo that ushered in a new era of brain-behavior research and greatly expanded our understanding of the neural processes of language. Toward the end of the 20th century, sophisticated neuroimaging approaches allowed for the visualization of both structural and functional brain activity associated with language processing in both healthy individuals and in those with language disturbance. More recently, language is thought to be mediated by a much broader expanse of neural networks that covers a large number of cortical and subcortical regions and their interconnecting fiber pathways. Injury to both grey and white matter has been seen to affect the complexities of language in unique ways that have altered how we think about brain-language relationships. The findings that support this paradigm shift are described here along with the methodologies that helped to discover them, with some final thoughts on future directions, techniques, and treatment interventions for those with communication impairments. (JINS, 2017, 23, 741-754)

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Section: Future Possibilitiesmentioning

confidence: 99%

What Do Language Disorders Reveal about Brain–Language Relationships? From Classic Models to Network Approaches

Dronkers

Ivanova

Baldo

2017

J Int Neuropsychol Soc

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“…In summary, these ten selected articles from the recent ASTNR meeting highlight the potential applications for stem cell therapy in neurological disorders, detailing the laboratory evidence on the safety, efficacy, and mechanism of action of these transplantable cells, altogether forming the basis for the clinical trials [30][31][32][33]. Given the prevalence of stroke, many patients would greatly benefit from novel treatments that capitalize on the promising therapeutic benefits of stem cells.…”

Section: Resultsmentioning

confidence: 99%

An update on stem cell therapy for neurological disorders: cell death pathways as therapeutic targets

et al. 2017

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Here, we compiled ten papers detailing recent strides in the field of stem cell therapy, which address critical issues relevant to pursuing this experimental treatment for clinical applications in brain disorders. Topics include efficacy, safety, and mechanism of action underlying cell therapy, emerging technologies and combination pharmacotherapies with cell transplantation directed at improving the functional outcomes, and evaluation of key translational components of advancing novel therapeutics to the clinic, including the need for vis-à-vis comparisons with the gold standard of treatment post-injury (i.e., physical rehabilitation). A bioethics paper is also incorporated here to further appreciate the current status of cell therapy in the community setting. The overall goal of this special volume is to provoke a meaningful assessment of the lessons we have learned in recent years and to use such knowledge to carefully translate safe and effective applications of cell therapy, and its mechanism of action for the treatment of neurological disorders.

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“…44 This was undertaken as a single centre study with no control group. Safety was the primary outcome and patients were followed for 2 years post-implant.…”

Section: Late Subacute or Chronic Strokementioning

confidence: 99%

Clinical trial design for stem cell therapies in stroke: What have we learned?

Muir

2017

Neurochemistry International

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Stem cells of various sources have been investigated in a series of small, safety and feasibility-focused studies over the past 15 years. Understanding of mechanisms of action has evolved and the trial paradigms have become focused on two different approaches -one being an early subacute delivery of cells to reduce acute tissue injury and modify the tissue environment in a direction favourable to reparative processes (for example by being anti-inflammatory, antiapoptotic, and encouraging endogenous stem cell mobilisation); the other exploring later delivery of cells during the recovery phase after stroke to modulate the local environment in favour of angiogenesis and neurogenesis. The former approach has generally investigated intravenous or intra-arterial delivery of cells with an expected paracrine mode of action and no expected engraftment within the brain. The latter has explored direct intracerebral implantation adjacent to the infarct. Several relevant trials have been conducted, including two controlled trials of intravenously delivered bone marrow-derived cells in the early subacute stage, and two small singlearm phase 1 trials of intracerebrally implanted cells. The findings of these studies and their implications for future trial design are considered.Introduction:

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Human neural stem cells in patients with chronic ischaemic stroke (PISCES): a phase 1, first-in-man study

Abstract: ReNeuron Limited.

Cited by 359 publications

References 32 publications

What Do Language Disorders Reveal about Brain–Language Relationships? From Classic Models to Network Approaches

What Do Language Disorders Reveal about Brain–Language Relationships? From Classic Models to Network Approaches

An update on stem cell therapy for neurological disorders: cell death pathways as therapeutic targets

Clinical trial design for stem cell therapies in stroke: What have we learned?

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