Human Neutrophils Support Thrombin Generation in Peritonitis

Lakbakbi, Souad; Rieu, Philippe; Nguyên, Philippe

doi:10.3747/pdi.2014.00187

Cited by 2 publications

(1 citation statement)

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“…IIID8 is commercially available (4509, American Diagnostica) and binds to the N-terminal domain of the extracellular domain of TF (amino acids, 1-25) [ 48 , 49 ]. IIID8 has been used previously for immunofluorescence, flow cytometry, and western blot [ [52] , [53] , [54] , [55] , [56] ].…”

Section: Methodsmentioning

confidence: 99%

Detection of tissue factor–positive extracellular vesicles using the ExoView R100 system

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Hisada

Hazeldine

et al. 2023

Research and Practice in Thrombosis and Haemostasis

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Section: Methodsmentioning

confidence: 99%

Detection of tissue factor–positive extracellular vesicles using the ExoView R100 system

Price

Hisada

Hazeldine

et al. 2023

Research and Practice in Thrombosis and Haemostasis

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Tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in the peritoneal fluid in patients with peritonitis – is the key towards intraperitoneal adhesions and complications?

Ziętek

2020

Pomeranian Journal of Life Sciences

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IntroductionThe concentrations of tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in the peritoneal fluid and blood plasma in patients with peritonitis were examined. The fibrinogenesis of the peritoneal cavity is not well-known although it is regarded as the main cause of intraperitoneal adhesions and the complications that arise from this.Materials and methodsThe study enrolled a group of 77 consecutive patients with peritonitis, 28 women and 49 men aged 18–79 years (with an average age of 45 ±18 years). The patients were divided into 2 subgroups: those with complications (n = 64) and those without (n = 13). Concentrations of TF and TFPI in the peritoneal fluid and blood plasma of patients were examined.ResultsIn the peritoneal fluid, patients with complications had a higher concentration of TF (p < 0.007), but a lower concentration of TFPI (p < 0.0006). In blood plasma, TF was higher but TFPI was lower (p < 0.00001 in both). The area under curve (AUC) for TF and TFPI was 0.763 and 0.93 respectively, the cut-off point was 809.08 pg/mL and 21.6 pg/mL, respectively. The positive predictive value (PPV) and negative predictive value (NPV) for TF was 68% and 75% and for TFPI, 80% and 85%, respectively.ConclusionsThe data can be taken as an example of cross-linking between extravascular coagulation and intraperitoneal adhesions. On the basis of TF and TFPI, it is clearly illustrated that there is some connection between coagulation and peritoneal fibrinogenesis, which could be involved in the pathogenesis of many complications in abdominal surgery and also indicate therapeutic targets.

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Human Neutrophils Support Thrombin Generation in Peritonitis

Cited by 2 publications

References 10 publications

Detection of tissue factor–positive extracellular vesicles using the ExoView R100 system

Detection of tissue factor–positive extracellular vesicles using the ExoView R100 system

Tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in the peritoneal fluid in patients with peritonitis – is the key towards intraperitoneal adhesions and complications?

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