Human Norovirus Genogroups Detected from Acute Gastroenteritis Patients in Seoul from May 2013 to April 2015

Ham, Heejin; Oh, Seah; Seung, Hyun-Jung; Jang, Jung-Im; Han, Changho

doi:10.4167/jbv.2015.45.4.376

Cited by 5 publications

(2 citation statements)

References 5 publications

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“…Therefore, it is possible that the novel GII.17 variants had already been circulating as an endemic strain in South Korea before March 2015. This possibility is strongly supported by a recent report of a noticeable increase in GII.17 in stool samples of hospitalized patients during first half of 2015 in Seoul, South Korea [ 48 ]. Moreover, increased detection of GII.17 NoV in acute gastroenteritis in children after November 2014 partly supports this possibility [ 49 ].…”

Section: Discussionsupporting

confidence: 56%

Occurrence of novel GII.17 and GII.21 norovirus variants in the coastal environment of South Korea in 2015

et al. 2017

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Human norovirus (HNoV), a positive-sense RNA virus, is the main causative agent of acute viral gastroenteritis. Multiple pandemic variants of the genogroup II genotype 4 (GII.4) of NoV have attracted great attention from researchers worldwide. However, novel variants of GII.17 have been overtaking those pandemic variants in some areas of East Asia. To investigate the environmental occurrence of GII in South Korea, we collected water samples from coastal streams and a neighboring waste water treatment plant in North Jeolla province (in March, July, and December of 2015). Based on capsid gene region C analysis, four different genotypes (GII.4, GII.13, GII.17, and GII.21) were detected, with much higher prevalence of GII.17 than of GII.4. Additional sequence analyses of the ORF1-ORF2 junction and ORF2 from the water samples revealed that the GII.17 sequences in this study were closely related to the novel strains of GII.P17-GII.17, the main causative variants of the 2014–2015 HNoV outbreak in China and Japan. In addition, the GII.P21-GII.21 variants were identified in this study and they had new amino acid sequence variations in the blockade epitopes of the P2 domain. From these results, we present two important findings: 1) the novel GII.P17-GII.17 variants appeared to be predominant in the study area, and 2) new GII.21 variants have emerged in South Korea.

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Section: Discussionsupporting

confidence: 56%

Occurrence of novel GII.17 and GII.21 norovirus variants in the coastal environment of South Korea in 2015

et al. 2017

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“…Group II NoV caused the predominant cause of acute gastroenteritis in many countries (71.4% of NoV affected patients in Korea) [910], and large portion of NoV outbreak caused by infected humans (64% in the US) [11]. To date, high-profile of outbreaks of acute gastroenteric illness in Korea have focused on the food and water borne transmission, and led to serious efforts to assess and control the food contamination and food handlers [12].…”

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confidence: 99%

Norovirus Outbreak in a Kindergarten: Human to Human Transmission among Children

Kim

Ryu

et al. 2019

Infect Chemother

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An outbreak of acute gastroenteritis was reported from a kindergarten on January 5, 2018 and investigation was conducted. A case was defined as a kindergartener presented with vomiting or diarrhea twice a day between January 1 and January 5, 2018. All kindergarteners were interviewed to identify the factor associated with case development. Fifteen (31.3%) children of a total of 48 were identified as cases, and four were confirmed to be Group II, Norovirus positive. In our study, based on the pattern of epidemic curve and different attack rate by classroom in a kindergarten, Norovirus was likely transmitted from human to human.

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Re-emergence of a GII.4 Norovirus Sydney 2012 Variant Equipped with GII.P16 RdRp and Its Predominance over Novel Variants of GII.17 in South Korea in 2016

et al. 2017

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Noroviruses are major causative pathogen of nonbacterial acute gastroenteritis worldwide. Of the seven genogroups of noroviruses suggested recently, genogroup II genotype 4 (GII.4) had been the most common genotype identified in hospitalized patients in the last few decades. However, since the latter half of 2014, new variants of GII.17 have been reported as the main causes of outbreaks over GII.4 in East Asia and have also occurred in America and Europe. In this study, we monitored norovirus GII in coastal streams at South Gyeongsang province and South Jeolla province of South Korea from March 2015 to May 2016. Norovirus GII.17 capsid sequences were predominantly detected until September 2015 in water samples. However, we found that the number of positive cases of the norovirus GII.4 Sydney 2012 capsid sequence has been increasing since December 2015, overtaking that of GII.17 in 2016. The RdRp genotype of this predominant GII.4 variant in 2016 was identified as GII.P16. The emergence and predominance of the GII.4 pandemic capsid sequence harboring a different RdRp genotype suggested the potential for a future pandemic.

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Human Norovirus Genogroups Detected from Acute Gastroenteritis Patients in Seoul from May 2013 to April 2015

Cited by 5 publications

References 5 publications

Occurrence of novel GII.17 and GII.21 norovirus variants in the coastal environment of South Korea in 2015

Occurrence of novel GII.17 and GII.21 norovirus variants in the coastal environment of South Korea in 2015

Norovirus Outbreak in a Kindergarten: Human to Human Transmission among Children

Re-emergence of a GII.4 Norovirus Sydney 2012 Variant Equipped with GII.P16 RdRp and Its Predominance over Novel Variants of GII.17 in South Korea in 2016

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