Human omentin-1 reduces vascular insulin resistance and hypertension in Otsuka Long-Evans Tokushima Fatty rats

Okamura, Yuta; Adachi, Ko; Niijima, Ryo; Kodama, Tomoko; Otani, Kosuke; Okada, Muneyoshi; Yamawaki, Hideyuki

doi:10.1007/s00210-023-02795-w

Cited by 2 publications

(2 citation statements)

References 31 publications

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“…It is possible that omentin-1 works by blocking the NF-κB pathway and triggering the AMPK-and Akt-dependent pathways [54]. Anti-diabetic medications may have an impact on the level of circulating omentin-1, which is inversely linked to the incidence of type 2 diabetes and associated complications, such as cardiomyopathy, retinopathy, and diabetic vascular disease [55].…”

Section: Insulin Sensitivitymentioning

confidence: 99%

“…Omentin-1's positive effects on vascular function, including vasodilation, anti-inflammatory actions, and potential anti-atherosclerotic effects, suggest potential applications in cardiovascular diseases [72,73]. Therapies aimed at increasing omentin-1 levels or enhancing its activity could be explored for conditions such as atherosclerosis, hypertension, and other cardiovascular disorders [45,55,74].…”

Section: Cardiovascular Diseasesmentioning

confidence: 99%

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Omentin: A Key Player in Glucose Homeostasis, Atheroprotection, and Anti-Inflammatory Potential for Cardiovascular Health in Obesity and Diabetes

Sena

2024

Biomedicines

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Omentin is an adipokine mainly produced by visceral fat tissue. It has two isoforms, omentin-1 and omentin-2. Omentin-1 is predominantly secreted by visceral adipose tissue, derived specifically from the stromal vascular fraction cells of white adipose tissue (WAT). Levels of omentin-1 are also expressed in other WAT depots, such as epicardial adipose tissue. Omentin-1 exerts several beneficial effects in glucose homeostasis in obesity and diabetes. In addition, research has suggested that omentin-1 may have atheroprotective (protective against the development of atherosclerosis) and anti-inflammatory effects, potentially contributing to cardiovascular health. This review highlights the potential therapeutic targets of omentin-1 in metabolic disorders.

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Section: Insulin Sensitivitymentioning

confidence: 99%

Section: Cardiovascular Diseasesmentioning

confidence: 99%

Omentin: A Key Player in Glucose Homeostasis, Atheroprotection, and Anti-Inflammatory Potential for Cardiovascular Health in Obesity and Diabetes

Sena

2024

Biomedicines

View full text Add to dashboard Cite

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Long-Term Prognostic Value of Adipocytokines in Patients with Acute Coronary Syndrome: An 8-Year Clinical Prospective Cohort Study

Wang,

Bu,

Wei

et al. 2024

JIR

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Purpose To elucidate the predictive values of adipocytokines in patients with acute coronary syndrome (ACS). Patients and Methods Overall, 297 patients with ACS were consecutively enrolled in this prospective cohort study between June 2015 and July 2017 and completed follow-up with a median follow-up time of 6.5 years. For consistency, the last visit date was June 20, 2023. Serum levels of retinol-binding protein-4 (RBP4), interleukin-1β (IL-1β), monocyte chemoattractant protein 1(MCP-1), adrenomedullin (ADM), netrin 1 (NTN 1), and omentin were measured using enzyme-linked immunosorbent assay. Follow-up data were collected during clinical visits or through telephone interviews at 1, 3, 6, 12 months, and annually. The primary endpoint was defined as major adverse cardiovascular events (MACEs), including all-cause mortality, rehospitalization for percutaneous coronary intervention, and severe angina requiring rehospitalization. Results All biomarkers displayed a good diagnostic ability of MACEs. The Kaplan–Meier curve showed that the cumulative survival rates of high level of RBP4, IL-1β, and MCP-1 and low level of the ADM, NTN1, and omentin had lower cumulative survival rates (Log rank tests: all p<0.05). After adjustment in the Cox hazard proportional model, the results were RBP4 ≥ 6.87 ng/mL, hazard ratio (HR)=2.512, p=0.003; IL-1β≥ 58.95 pg/mL, HR=3.809, p<0.001; MCP-1 ≥ 401.75 pg/mL, HR=4.047, p<0.001; ADM≤120.01 ng/mL, HR=3.930, p=0.008; NTN1 ≤63.7 pg/mL, HR=3.345, p=0.007; omentin ≤ 4.54 ng/mL, HR=2.830, p=0.004. P-values for interaction were > 0.05 in the sex, age, and dyslipidemia subgroups. Conclusion Pro-inflammation adipocytokines RBP4, IL-1β, and MCP-1 increased and anti-inflammation biomarkers ADM, NTN1, and omentin decreased were independently associated with a higher risk of MACEs in patients with ACS.

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Human omentin-1 reduces vascular insulin resistance and hypertension in Otsuka Long-Evans Tokushima Fatty rats

Cited by 2 publications

References 31 publications

Omentin: A Key Player in Glucose Homeostasis, Atheroprotection, and Anti-Inflammatory Potential for Cardiovascular Health in Obesity and Diabetes

Omentin: A Key Player in Glucose Homeostasis, Atheroprotection, and Anti-Inflammatory Potential for Cardiovascular Health in Obesity and Diabetes

Long-Term Prognostic Value of Adipocytokines in Patients with Acute Coronary Syndrome: An 8-Year Clinical Prospective Cohort Study

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