Human Opioid μ-receptor A118G Polymorphism May Protect Against Central Pruritus by Epidural Morphine for Postcesarean Analgesia

Pruritus

“…These results may suggest that patients with the A118G SNP in the OPRM1 may be protected from the itch in cholestasis [27]. Indeed, the presence of the G or A allele in A118G SNP has been associated with a difference in the degree of pruritus secondary to epidural morphine [28]. In addition, ethnicity may inform the experience of side effects, including pruritus, from the administration of intravenous morphine in children [29].…”