Through five experimental studies we measured moral reactions to brain implants. We used three different measurements: 1) moral approval, or the general acceptance of brain-enhancing implants and people getting such implants, 2) perceived unfairness of the enhancement and 3) dehumanization of persons using brain implants. In our vignettes, the enhancement was on one of three levels: a) it alleviated an ailment, b) it gave optimal human level performance or c) it gave superhuman performance. Studies 1 to 4 were about memory enhancement, Study 5A about en-hancing general intelligence and Study 5B about enhancing emotional stability.We successfully showed that moral approval, sense of fairness and dehumanization are rele-vant in contexts where moral implications of new technologies are being evaluated and that while people generally approve of curing ailments, they are more cautious of unfamiliar levels of en-hancement. Furthermore, we linked the tendency to condemn transhumanist technologies to fac-tors associated with disgust sensitivity (the binding orientation of the Moral Foundations Theory and sexual disgust) and found that science fiction hobbyism is linked to approval of brain im-plants. We also successfully ruled out possible idiosyncrasies associated with our stimulus materi-als and eliminated multiple alternative explanations common in the study of moral cognition