Human osteoblast response to PTFE surfaces

Walsh, William R.; Olmedo, Margaret; Kim, H.D.; Zou, L.; Weiss, A.-P. C.

doi:10.1016/0267-6605(94)90118-x

Cited by 12 publications

(8 citation statements)

References 7 publications

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“…Hence, a strong interface with bone tissue cannot be achieved and an extended time period is required for in vivo fixation of the implant to occur. Previous short‐term (3 h, 3 days, and 5 days) in vitro cell studies have shown that ePTFE does not support human osteoblast growth 28, 33. Our strategy to improve the bone‐bonding ability of ePTFE has been to surface‐modify the material using γ‐irradiation‐induced grafting of the phosphate‐containing monomers, MAEP and MOEP 24–26.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and studies of blue light emitting polymers containing triphenylamine‐substituted fluorene and diphenylanthracene moiety

Barve

Raut

Mishra

et al. 2011

J of Applied Polymer Sci

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Photoluminescent (PL) polymers containing triphenylamine-substituted fluorene and diphenylanthracene (DPA) units were synthesized by aromatic nucleophilic substitution reaction. The light emitting polymers (LEPs) contains hole-transporting triphenylamine (TPA) groups at the C-9 position of fluorene and DPA-emitting segments in the main chain. The obtained polymers were soluble in various organic solvents and thermally stable. The synthesized polymers were successfully characterized by elemental analyses, FTIR and, 1 H NMR spectroscopy. The electrochemical measurements and optical properties of the polymers were also studied. The obtained polymers showed significant blue emission.

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Section: Resultsmentioning

confidence: 99%

Synthesis and studies of blue light emitting polymers containing triphenylamine‐substituted fluorene and diphenylanthracene moiety

Barve

Raut

Mishra

et al. 2011

J of Applied Polymer Sci

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“…22 We also seeded the MSC on noncoated e-P as control, because Friedmann et al 23 reported the good osteogenic response of noncoated e-P using osteoblastic cells. However, Walsh et al 10 concluded that the surfaces of e-P did not support osteoblast growth.…”

Section: Discussionmentioning

confidence: 97%

“…The loosening and bone tunnel enlargement might be due to inadequate affinity of the e-P ligaments for osteogenic cells, because the ligaments do not support osteoblast growth. 10 These results of the e-P in dental/orthopedic applications indicate the necessity of surface chemical modification of e-P, which permits sufficient cell attachment followed by osteogenic differentiation. We have developed an e-P coated with both a poly-amino-acid urethane copolymer (PAU) and collagen (abbreviated as e-PPC).…”

Section: Introductionmentioning

confidence: 95%

Osteogenic Potential of Mesenchymal Stem Cells on Expanded Polytetrafluoroethylene Coated with Both a Poly-Amino-Acid Urethane Copolymer and Collagen

Matsumoto

Hattori

Matsushima

et al. 2011

Tissue Engineering Part A

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We have developed an expanded polytetrafluoroethylene polymer (e-P) coated with both poly-amino-acid urethane copolymer and collagen (e-PPC) to be used for cell culture substrata. Rat mesenchymal stem cells (MSC) were cultured on the e-P and e-PPC polymers in the presence of dexamethasone. After 24 h, the MSC contacted well with the e-PPC surface and after 14 days, the MSC showed high levels of alkaline phosphatase activity, and calcium and bone-specific osteocalcin protein deposition. The MSC cultured on these polymers for 1 week were then implanted at rat subcutaneous sites and harvested after 4 weeks. Microcomputed tomography as well as histological analyses showed that any hard tissue could not be seen in implants of the MSC/e-P composites, whereas new bone formation could be detected in the MSC/e-PPC composites. These in vitro as well as in vivo results confirmed the importance of polymer surface to support the osteogenic differentiation, which resulted in new bone formation. The surface modification using poly-amino-acid urethane copolymer and collagen together with tissue engineering technology might facilitate bone anchoring to the polymers for dental and orthopedic applications.

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“…2,21,33 Animal and clinical follow-up studies have demonstrated significant fibrous ingrowth into the synthetic matrices, 14,22,42,44,48 without bony ingrowth. 54 Although the only clinical report in which Gore-Tex was used for CC stability showed good results, 41 complications associated with Gore-Tex implants have been reported in other orthopaedic applications, particularly ACL reconstruction. Although early reports on the use of Gore-Tex for ACL reconstruction were encouraging, [7][8][9]17,31,53 other studies showed mixed results with high failure rates, 18,19,45,47,58 often associated with tibial and femoral osteolysis.…”

Section: Discussionmentioning

confidence: 97%

Failure of acromioclavicular reconstruction using Gore-Tex graft due to aseptic foreign-body reaction and clavicle osteolysis: A case report

Stewart

Ahmad

2004

Journal of Shoulder and Elbow Surgery

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Human osteoblast response to PTFE surfaces

Cited by 12 publications

References 7 publications

Synthesis and studies of blue light emitting polymers containing triphenylamine‐substituted fluorene and diphenylanthracene moiety

Synthesis and studies of blue light emitting polymers containing triphenylamine‐substituted fluorene and diphenylanthracene moiety

Osteogenic Potential of Mesenchymal Stem Cells on Expanded Polytetrafluoroethylene Coated with Both a Poly-Amino-Acid Urethane Copolymer and Collagen

Failure of acromioclavicular reconstruction using Gore-Tex graft due to aseptic foreign-body reaction and clavicle osteolysis: A case report

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