Human Papilloma Virus–Associated Lips Verrucous Carcinoma in HIV-Infected Male

Socio, Giuseppe Vittorio De; Bidovanets, Olena; Tomassini, Gian Marco; Fanelli, Luca; Simonetti, S.

doi:10.1177/2325957417711255

Cited by 6 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, the number of HPV + HNC cases are increasing in HIV/AIDS population compared to non-HPV + HNC cases (in the same population). It is worth mentioning that in some HIV patients, HPV + HNC (especially HPV + OSCCs) have been reported concurrently with HPV-associated anal cancers [61,62], especially in men who have sex with men. Overall, the number of HPV + HNC cases (i.e., in HIV/AIDS and non-HIV/AIDS populations) are higher in men compared to women [59,63,64].…”

Section: Influence Of Immunosuppression In Hpv + Hncmentioning

confidence: 99%

“…While most patients with HIV/HPV co-infections on HAART therapy have a reduced risk of developing HPV-associated cancer (cervical cancer) compared to patients on non-HAART therapy (reviewed in ref. [93]), some HIV/HPV patients on HAART therapy seem to have a high risk of developing HPV-associated oral lesions/cancers [62,94,95]; the risk is suggested to be due to longer life expectancy as a result of HAART therapy. It is unclear why HAART therapy may have different indirect effects on HPV + HNC versus HPV-associated cervical cancers.…”

Section: Challenges Associated With Hpv + Hncmentioning

confidence: 99%

See 1 more Smart Citation

A Current Update on Human Papillomavirus-Associated Head and Neck Cancers

Tumban

2019

Viruses

179

163

View full text Add to dashboard Cite

Human papillomavirus (HPV) infection is the cause of a growing percentage of head and neck cancers (HNC); primarily, a subset of oral squamous cell carcinoma, oropharyngeal squamous cell carcinoma, and laryngeal squamous cell carcinoma. The majority of HPV-associated head and neck cancers (HPV + HNC) are caused by HPV16; additionally, co-factors such as smoking and immunosuppression contribute to the progression of HPV + HNC by interfering with tumor suppressor miRNA and impairing mediators of the immune system. This review summarizes current studies on HPV + HNC, ranging from potential modes of oral transmission of HPV (sexual, self-inoculation, vertical and horizontal transmissions), discrepancy in the distribution of HPV + HNC between anatomical sites in the head and neck region, and to studies showing that HPV vaccines have the potential to protect against oral HPV infection (especially against the HPV types included in the vaccines). The review concludes with a discussion of major challenges in the field and prospects for the future: challenges in diagnosing HPV + HNC at early stages of the disease, measures to reduce discrepancy in the prevalence of HPV + HNC cases between anatomical sites, and suggestions to assess whether fomites/breast milk can transmit HPV to the oral cavity.

show abstract

Section: Influence Of Immunosuppression In Hpv + Hncmentioning

confidence: 99%

Section: Challenges Associated With Hpv + Hncmentioning

confidence: 99%

A Current Update on Human Papillomavirus-Associated Head and Neck Cancers

Tumban

2019

Viruses

179

163

View full text Add to dashboard Cite

show abstract

“…Developing the cancerous lesion after HPV infection may be associated with the immune status of the patients. De Socio et al has reported a case of HPVassociated lips verrucous carcinoma in HIV-infected male patient [13]. HIV-positive patients have a 2 to 3 times higher prevalence of oral HPV infection than HIVnegative patients.…”

Section: Association Between Vce and Human Papilloma Virus Infectionmentioning

confidence: 99%

Verrucous Carcinoma of the Esophagus: Its Unique Etiology and Association with Human Papilloma Virus

2020

J Cancer Immunol

View full text Add to dashboard Cite

Verrucous carcinoma of the esophagus (VCE) is a rare variant of esophageal squamous cell carcinoma. Most cases of VCE presents as an exophytic, slow-growing mass with a superficial growth pattern. Even when VCE exhibits a characteristic pattern during an endoscopic examination, it is very difficult to make a definitive diagnosis of VCE preoperatively, because biopsy specimens are only characterized by nonspecific acanthosis and hyperkeratosis or parakeratosis associated with inflammation. As well as the characteristics of VCE, the etiology of the disease is even unique. VCE is typically associated with chronic mucosal irritation such as reflux esophagitis, achalasia, and lye ingestion that has resulted in esophageal inflammation or a long-term local disease process in addition to the classic risk factors of nicotine and alcohol consumption. Recent studies had indicated that human papilloma virus (HPV) infection might be associated with VCE. While HPV may be related to VCE initiation, involvement of HPV in the etiology of VCE requires further investigation. VCE's etiology and therapeutic strategy, including the vaccination against HPV, should be established.

show abstract