Human papilloma virus genotyping in women with abnormal cytology

Olejniczak, Tomasz; Rabiega-Gmyrek, Dorota; Niepsuj-Biniaś, Joanna; Jachowski, Paweł; Guglas-Bochyńska, Bogna; A, Latos Bieleńska; Woźniak, Jakub; Opala, Tomasz

doi:10.17772/gp/58639

Cited by 3 publications

(2 citation statements)

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“…It is estimated that, in 8–14% of cases, co-infection occurs with miscellaneous types of the virus. Taking into consideration the features of oncogenic potential, HPV viruses have been divided into such types as: Low Risk HPV types include HPV 6; 11; 40; 42; 43; 44; 54; 61; 72; and 81 as well as High Risk HPV types associated with an increased risk of neoplastic transformation: types 16; 18; 26; 31; 33; 35; 39; 45; 51; 52; 53; 56; 58; 59; 66; 68; 73; and 82 [ 10 , 13 , 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Sexual Behavior and the Awareness Level of Common Risk Factors for the Development of Cervical, Anogenital and Oropharyngeal Cancer among Women Subjected to HR HPV DNA-Testing

Wencel-Wawrzeńczyk

Lewitowicz

Lewandowska

et al. 2022

IJERPH

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The human papillomavirus (HPV) is a significant health problem that increases the risk of developing precancerous lesions, cancer of the anogenital area, as well as mouth and throat cancers. The aim of the study was to analyze the awareness level of common risk factors and the preferred sexual behavior of women aged 18–68, who underwent a molecular evaluation of common HR-HPV from material collected from the cervix. The study was conducted at the Jan Kochanowski University in Kielce, Collegium Medicum, in the period from December 2019 to August 2020 on a group of 201 women. A diagnostic survey and the HR-HPV molecular test were used in the research. All of the obtained samples were subjected to identification of and testing for the presence of HR-HPV by the Cobas 4800 platform (Roche Diagnostic©, Basel, Switzerland). We presented the statistically significant relationships between the age of the respondents and the awareness of the impact. The women aged over 43 years old presented the widest spectrum of information concerning HPV-related lesions. Conclusion: Our study highlights the necessity of educating women about the prevention of sexually transmitted infections.

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Section: Introductionmentioning

confidence: 99%

Sexual Behavior and the Awareness Level of Common Risk Factors for the Development of Cervical, Anogenital and Oropharyngeal Cancer among Women Subjected to HR HPV DNA-Testing

Wencel-Wawrzeńczyk

Lewitowicz

Lewandowska

et al. 2022

IJERPH

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“…The important aspects in preventing the development of cervical cancer involve both cytological examination and the detection of HPV infection [5,6]. The current guidelines of the Polish Society of Gynecologists and Obstetricians recommend performing an HPV test in case of obtaining an abnormal cytology result (ASC-US, LSIL) as an alternative to a repeat cytology test [7]. There are many methods for detecting HPV infection, which we can divide into three main groups: nucleic acid hybridization assays, signal amplification assays and nucleic acid amplification assays [5].…”

Section: Introductionmentioning

confidence: 99%

Food and drug administration — approved molecular methods for detecting human papillomavirus infection

Sitarz

Szostek

2019

Ginekol Pol

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In the world, there are many tests that allow the detection of HPV infection. These tests are based on different operating principles and have different levels of sensitivity. The first test to detect HPV infection was approved by the Food and Drug Administration in 2003. Since then, the FDA has approved five more commercial tests for this purpose, the last one in 2018. This paper discusses the principles of molecular tests to detect HPV, which have been approved by the FDA, the main differences between them, as well as their advantages and disadvantages.

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Pap Cytology and Human Papillomavirus (HPV) Genotypes in Western Romania: A Retrospective Analysis

Ciurescu,

Ioan,

Gorun

et al. 2024

Cureus

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Background and objectiveVigorous proactive measures are needed to combat cervical cancer, linked to the human papillomavirus (HPV). HPV genotyping aids in identifying high-risk strains, enabling targeted screening and risk assessment. This informs treatment decisions, reducing cervical cancer cases. In light of this, we conducted a retrospective analysis of Pap cytology and HPV genotypes to assess western Romania's new screening program. Understanding HPV prevalence, genotype correlations, and risk factors will help refine risk stratification models and enhance public health strategies. MethodologyThis retrospective study analyzed Pap smears from 195 patients with a mean age of 40 years [standard deviation (SD): 12 years], with a peak of incidence between 25 and 30 years. The patient cohort, with equal representation from urban and rural areas, comprised sexually active women of reproductive age presenting to the Gynaecology Ambulatory of the Municipal Emergency Clinical Hospital Timișoara over two years. Patients not sexually active and those in menopause were excluded. HPV genotyping was done on 67 patients. Data were analyzed using JASP, employing descriptive statistics, frequency tables, contingency tables, chi-squared test, odds ratio, and Fisher's exact test. ResultsAmong 195 patients undergoing Pap smear tests, the most prevalent finding was negative (77.95%), indicating no abnormal cells detected. A smaller proportion of patients exhibited low-grade squamous intraepithelial lesions (LSIL, 11.28%) or atypical squamous cells of undetermined significance (ASC-US, 8.72%) findings. High-grade lesions (HSIL, ASC-H) were rare. For cytology grading, Category II (CII) was the most prevalent (75.90%), followed by Category III (CIII, 24.10%). HPV genotyping was performed on a subset of patients (n=67). Among them, Type 16 was the most frequent (28.36%), followed by Other high-risk types (20.89%), Type 16 (28.35%), and Type 18 (13.43%). HPV testing was not performed for 65.64% of the patients. Overall, the study suggests that a significant majority of the patients had normal Pap smears. However, a small proportion did have abnormal findings, including HPV infection. These findings highlight the importance of Pap smear screening for early detection of cervical abnormalities. ConclusionsOur study from western Romania highlights the importance of HPV testing and Pap cytology in cervical cancer prevention. HPV testing is a potent tool for identifying high-risk women, and when combined with Pap cytology, it provides a more comprehensive screening strategy. Our research also revealed a diverse HPV genotype distribution, suggesting the need for broader-spectrum vaccines like the nonavalent vaccine. Despite our study's limitations, our findings underscore the need for including HPV testing in national screening guidelines. Future research should focus on larger studies and the cost-effectiveness of broaderspectrum vaccines. Implementing policies based on these findings could lead to more effective cervical cancer prevention ...

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Human papilloma virus genotyping in women with abnormal cytology

Abstract: Streszczenie Cel pracy: Ocena obecności zakażenia HPV (Human Papilloma Virus) i identyfikacja najczęściej występujących typów HPV u pacjentek z nieprawidłowym wynikiem cytologii (nieprawidłowości komórek nabłonka płaskiego -wg klasyfikacji Bethesda). Materiał i metoda:

Cited by 3 publications

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Sexual Behavior and the Awareness Level of Common Risk Factors for the Development of Cervical, Anogenital and Oropharyngeal Cancer among Women Subjected to HR HPV DNA-Testing

Sexual Behavior and the Awareness Level of Common Risk Factors for the Development of Cervical, Anogenital and Oropharyngeal Cancer among Women Subjected to HR HPV DNA-Testing

Food and drug administration — approved molecular methods for detecting human papillomavirus infection

Pap Cytology and Human Papillomavirus (HPV) Genotypes in Western Romania: A Retrospective Analysis

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