Human papilloma virus in erosive oral lichen planus

Jontell, Mats; Watts, Susan L.; Wallström, Mats; Levin, L. Stefan; Sloberg, K.

doi:10.1111/j.1600-0714.1990.tb00841.x

Cited by 51 publications

(50 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…10) is a chronic inflammatory disease of unknown aetiology and immune pathogenesis, with a small malignant potential. Information on HPV infection in OLP is scanty, but the few studies published report a high frequency [106,107] from 27.3% (75), to 42.0% [108] or even 65.0% [109]. Both Gonzales-Moles [110] and Jontell [109] observed that only the erosive variant of OLP was found to be HPV positive but this was not confirmed in another study [111].…”

Section: Oral Benign Lesions Hpv-relatedmentioning

confidence: 99%

“…Information on HPV infection in OLP is scanty, but the few studies published report a high frequency [106,107] from 27.3% (75), to 42.0% [108] or even 65.0% [109]. Both Gonzales-Moles [110] and Jontell [109] observed that only the erosive variant of OLP was found to be HPV positive but this was not confirmed in another study [111]. In the recent systematic review of HPV and OPMDs, the prevalence of any HPV genotypes and only HPV-16 in OLP were 5.12% and 5.61 respectively [12].…”

Section: Oral Benign Lesions Hpv-relatedmentioning

confidence: 99%

See 1 more Smart Citation

Oral HPV Infection: Current Strategies for Prevention and Therapy

Syrjänen

Termine

Capra³

et al. 2012

CPD

View full text Add to dashboard Cite

Infection with High Risk (HR) Human Papillomaviruses (HPVs) is the main aetiological agent of Cervical Squamous Cell Carcinoma (CSCC) and also associated in a subgroup of other neoplasms, including Oropharyngeal Squamous cell Carcinoma (OPSCC). HPV infection, in genital as in oral mucosa, can also be subclinical or associated with benign proliferative lesions (common warts, condylomas, papillomas) caused mostly by infection with Low Risk (LR)-HPVs. In the last decades, extensive research has resulted in growing knowledge on HPV biology and specifically viral life cycle, biochemical properties of viral proteins and their interaction with the host proteins leading to potential new targets of prophylactic or therapeutic vaccines and therapies for HPV infection. In addition, notable progresses have been made in the field of diagnostics to detect HPV DNA or RNA. The recent epidemiological data suggest the significant changes in HPV endemic, due to the changes in sexual habits especially among young generations (i.e. early sexual debuts, multiple sexual partners, oral and anal sex); this scenario has urged on the need of adequate campaigns of primary (sexual education, vaccination programs) and secondary prevention (diagnostics of HPV-related diseases). Due to the growing interest on HPV infection and HPV related cancers, the authors made a narrative review of the literature on oral HPV infection and oral-genital transmission. After this, in view of the controversies about the strategies of therapy and prevention of HPV infection, the present review focuses on the current state of art about the available tools for the therapeutic and, if any, preventive management of oral HPV infection.

show abstract

Section: Oral Benign Lesions Hpv-relatedmentioning

confidence: 99%

Section: Oral Benign Lesions Hpv-relatedmentioning

confidence: 99%

Oral HPV Infection: Current Strategies for Prevention and Therapy

Syrjänen

Termine

Capra³

et al. 2012

CPD

View full text Add to dashboard Cite

show abstract

“…Thus the association between HPV and these lesions has provided a basis for suggestion of etiological role of HPV. 22 Though different agents have been proposed their role remains speculative.…”

Section: ) Infectious Agentsmentioning

confidence: 99%

Lichen Planus –A Review

Madalli¹

2013

IOSR-JDMS

View full text Add to dashboard Cite

“…Th is very recent report shows 70% of patients with OLP being positive for HPV-16. Only one small sample of patients showed higher prevalence of HPV in erosive lichen (11). Mattila and coworkers (12) have reported 15.9% of HPV-positive patients with atrophic OLP.…”

mentioning

confidence: 95%

“…Th e sequences of the forward and reverse primers used were FW (GP5+): 5'-TTTGTTACTGTGGTAGATACTAC-3' and REV (GP6+): 5'-AAAAATAAACTGTAAATCATATT-3'. Th is allows the detection of 37 HPV types, specifi cally 6,11,16, 18, 26, 31, 33, 35, 39, 40, 42, 45, 51, 52, 53, 54, 55, 56, 58, 59, 61, 62, 64, 66, 67, 68, 69, 70, 71, 72, 73 (MM9), 81, 82 (MM4), 83 (MM7), 84 (MM8), IS39, and CP6108. HPV typing was performed, however, due to low amounts of DNA it was not possible to analyze the results.…”

mentioning

confidence: 99%

The prevalence of human papillomavirus in patients with oral lichen planus and normal oral mucosa

Radochová¹,

L²,

Slezák³

2015

View full text Add to dashboard Cite

Oral lichen planus (OLP) is a chronic infl ammatory disorder that aff ects the oral mucous membrane. Th e prevalence of OLP in the population is considered to be 1%-2% (1). Th e etiology of OLP is not known. Th e immune system very probably plays the primary role in the development of this disease. During the last decades, several studies have suggested that human papillomaviruses (HPVs) are involved in the development of premalignant and malignant lesions (2). Th e causal role of HPV has been reported for OLP and oral squamous cell carcinoma, but there are wide variations in disease prevalence with regard to diff erent geographic populations (3). Th e aim of this study was to determine the prevalence of HPV on the mucosa in patients with OLP and compare it with healthy mucosa.Study protocol has been approved by the local ethical committee. Written informed consent was obtained from all subjects entering the study. Patients with OLP were included based upon following criteria: clinically diagnosed OLP according to objective examination (single physician) and histologically confi rmed OLP. OLP was classifi ed according to criteria previously published by World health Organization and modifi ed by van der Meij et al. (4). Smokers and patients with alcohol abuse history were excluded from the study. Sex-and age-matched controls were chosen from individuals undergoing various dental procedures with no known mucosal disease. Native tissue samples were sent for HPV genome detection. HPV DNA was extracted from native tissue. All samples were screened for the presence of HPV DNA by PCR amplifi cation with primers GP5+/ GP6+ located within the HPV L1 gene. Th e sequences of the forward and reverse primers used were FW (GP5+): 5'-TTTGTTACTGTGGTAGATACTAC-3' and REV (GP6+): 5'-AAAAATAAACTGTAAATCATATT-3'. Th is allows the detection of 37 HPV types, specifi cally 6,11,16, 18, 26, 31, 33, 35, 39, 40, 42, 45, 51, 52, 53, 54, 55, 56, 58, 59, 61, 62, 64, 66, 67, 68, 69, 70, 71, 72, 73 (MM9), 81, 82 (MM4), 83 (MM7), 84 (MM8), IS39, and CP6108. HPV typing was performed, however, due to low amounts of DNA it was not possible to analyze the results. Chi-square and Student t-test were used for comparisons. P value <0.05 was considered statistically signifi cant. A total of 45 patients with confi rmed diagnosis of OLP were examined for HPV, of whom, 33 (73.3%) were woman and 12 (26.7%) were men. Th e mean age of the patients was 56 years (±14.96) with an overall range of 33-77 years. Th e control group consisted of 24 individuals, 19 (79.2%) were women and 5 (20.8%) were men. Th e mean age of the individuals in control group was 56.1 years (±11.41) with an overall range of 29-81 years. Th ere was no statistical signifi cance according to age (p = 0.96) and gender (p = 0.59) between OLP patients and controls. Th ere were 24 (53.3%) HPV-positive patients with OLP and 21 (46.7%) patients were HPV-negative. In the control group there were 12 sub-

show abstract

Human papilloma virus in erosive oral lichen planus

Cited by 51 publications

References 23 publications

Oral HPV Infection: Current Strategies for Prevention and Therapy

Oral HPV Infection: Current Strategies for Prevention and Therapy

Lichen Planus –A Review

The prevalence of human papillomavirus in patients with oral lichen planus and normal oral mucosa

Contact Info

Product

Resources

About