Human Papillomavirus and head and neck cancer: Epidemiology and molecular biology

McKaig, Rosemary G.; Baric, Ralph S.; Olshan, Andrew F.

doi:10.1002/(sici)1097-0347(199805)20:3<250::aid-hed11>3.0.co;2-o

Cited by 254 publications

(136 citation statements)

References 166 publications

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“…(ii) All 27 bladder cancers due to schistosomiasis were associated with the presence of HPV-16 DNA, which can be detected in tumor and serum but not in PBF. In contrast, no serum HPV- 16 cancer diagnosis ͉ cancer treatment ͉ bilharziasis R ecent studies indicate that the human papillomavirus (HPV) is associated with a significant fraction of cervical (1,2), head͞neck (3), and schistosomiasis-associated bladder cancers (4). Cervical cancers are almost uniformly associated with HPV infection (5).…”

supporting

confidence: 90%

Sensitive detection of human papillomavirus in cervical, head/neck, and schistosomiasis-associated bladder malignancies

Yang

Khafagi

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

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We assayed for the presence of human papilloma virus (HPV) DNA in serum and͞or peripheral blood fraction (PBF) of individuals with cervical, head͞neck, or bladder cancer due to schistosomiasis. Using mass spectroscopy coupled with competitive PCR, HPV DNA was detected at the individual molecule level by using ''Mass-ARRAY'' assays. The resultant sensitivity was superior to real-time fluorescent PCR-based assays, while specificity was maintained. Our principal findings were: (i) Virtually all tested cervical cancers and schistosomiasis-associated bladder cancers, and a plurality of head͞neck cancers, are associated with HPV DNA in the tumor. (ii) All 27 bladder cancers due to schistosomiasis were associated with the presence of HPV-16 DNA, which can be detected in tumor and serum but not in PBF. In contrast, no serum HPV-16 DNA signal was detected in seven individuals with schistosomiasis-associated bladder cancers after surgical removal of the tumor. cancer diagnosis ͉ cancer treatment ͉ bilharziasis R ecent studies indicate that the human papillomavirus (HPV) is associated with a significant fraction of cervical (1, 2), head͞neck (3), and schistosomiasis-associated bladder cancers (4). Cervical cancers are almost uniformly associated with HPV infection (5). In a review of published reports, McKaig et al. (3) found the overall prevalence of HPV DNA in head and neck tumors to be 35%. More recently, Gillison et al. (6) used quantitative PCR (QPCR) to confirm these findings in a large study of 253 tumor samples. They detected HPV DNA in 25% of specimens. Khaled et al. (4) found that nearly 50% of schistosomiasis-caused bladder cancers had HPV DNA by in situ hybridization. This body of work argues that HPV could be a useful tag for tracking a considerable fraction of cervical, head͞neck, and schistosomiasis-associated bladder cancers.HPV types 16 and 18 are among the ''high-risk'' viral types, because their presence is associated with preneoplastic lesions and carcinomas. In contrast, the ''low-risk'' types, most commonly types 6 and 11, are typically associated with benign lesions. The oncogenic potential of HPV is principally due to two viral oncoproteins, E6 and E7. Differences in oncogenic potential among HPV types have been attributed to type-specific differences in the E6 and E7 proteins (7). The E6 protein of oncogenic HPV strains has been shown to interact with the p53 protein and promote its degradation via a ubiquitin-dependent pathway (7). The E7 oncoprotein, similarly, can complex with the retinoblastoma (Rb) protein and inactivate it (8). Both p53 and Rb are important tumor suppressor genes whose products regulate the cell cycle, orchestrate DNA repair processes, and are involved with programmed cell death or apoptosis. Disruption of these tumor suppressor proteins by HPV leads to propagation of mutational changes and cell immortalization.Since the work of Anker, Sidransky, and coworkers (9-11) established that abnormal genomic DNA can be detected in serum of cancer patients, the technique of examin...

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supporting

confidence: 90%

Sensitive detection of human papillomavirus in cervical, head/neck, and schistosomiasis-associated bladder malignancies

Yang

Khafagi

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

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“…The active role of HPV may be as a promoter in the multistep process of carcinogenesis in squamous cells of the UADT. Two viral oncoproteins of highrisk HPVs, E6 and E7, promote tumor progression by inactivation of p53 and retinoblastoma tumor suppressor gene products, respectively (92)(93)(94). These viral oncoproteins are capable of disrupting the cell-cycle regulatory pathways in the genetic progression to SCC.…”

Section: Virusesmentioning

confidence: 99%

Squamous Cell Carcinoma of the Upper Aerodigestive Tract: Precursors and Problematic Variants

Wenig

2002

Modern Pathology

120

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“…Respecto a infecciones virales como factor de riesgo, se ha detectado la presencia del VPH en tumores escamosos de laringe, sin embargo el análisis no ha evidenciado una relación directa con este cáncer, no así con el carcinoma escamoso orofaríngeo (amígdala palatina y base de lengua), sobre todo con el serotipo 16 y 18 del VPH 19,20 . La exposición ocupacional a agentes químicos como el cromo, níquel, radio, gas mostaza, productos intermedios de la producción de cuero y de proceso de madera se han descrito como otros factores de riesgo.…”

Section: Factores De Riesgo Y Prevenciónunclassified

Importancia de la epidemiología en cáncer laríngeo: Incidencia y mortalidad por carcinoma escamoso de laringe

2017

Rev. Otorrinolaringol. Cir. Cabeza Cuello

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Human Papillomavirus and head and neck cancer: Epidemiology and molecular biology

Cited by 254 publications

References 166 publications

Sensitive detection of human papillomavirus in cervical, head/neck, and schistosomiasis-associated bladder malignancies

Sensitive detection of human papillomavirus in cervical, head/neck, and schistosomiasis-associated bladder malignancies

Squamous Cell Carcinoma of the Upper Aerodigestive Tract: Precursors and Problematic Variants

Importancia de la epidemiología en cáncer laríngeo: Incidencia y mortalidad por carcinoma escamoso de laringe

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