Human papillomavirus and head and neck cancer: a systematic review and meta‐analysis

Hobbs, Christopher; Sterne, Jonathan A C; Bailey, Michael; Heyderman, Robert S.; Birchall, MA; Thomas, Steve

doi:10.1111/j.1749-4486.2006.01246.x

Cited by 328 publications

(268 citation statements)

References 32 publications

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“…Hobbs et alstudied the association between HPV and cancer in cases of head and neck squamous cell carcinoma. The strongest association was detected for tonsil (OR=15.1, 95%CI, 6.8-33.7), intermediate for oropharynx (OR=4.3, 95% CI, 2.1-8.9) and weakest for oral and larynx primary tumors (OR=2.0, 95% CI, 1.2-3.4 and 1.0-4.2 respectively) (Hobbs CGL et al, 2006). HPV11 is the most common cause of RRP and associated with a greater risk for progression to lung cancer than HPV6 (Dilorenzo et al, 1992;Rimell et al, 1997).…”

Section: Discussionmentioning

confidence: 96%

Whole Genome Analysis of Human Papillomavirus Genotype 11 from Cervix, Larynx and Lung

Chansaenroj

Theamboonlers²,

Junyangdikul³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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The prevalence of human papillomavirus genotypes differs in various target organs. HPV16 is the most prevalent genotype in the cervix while genotypes 6 and 11 are highly prevalent in skin and aero-digestive tract infections. In this study HPV11 positive specimens were selected from cervix, larynx and lung biopsy tissue to analyze the whole genome by PCR and direct sequencing. Five HPV11 whole genomes were characterized, consisting of two cervical specimens, two laryngeal specimens and one lung specimen. The results showed high homology of HPV11 in these organs. Phylogenetic analysis showed that all HPV11 derived from various organs belonged to the same lineage. Molecular characterization and functional studies can further our understanding of virulence, expression or transmission. Additional studies on functional protein expression at different organ sites will also contribute to our knowledge of HPV infection in various organs.

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Section: Discussionmentioning

confidence: 96%

Whole Genome Analysis of Human Papillomavirus Genotype 11 from Cervix, Larynx and Lung

Chansaenroj

Theamboonlers²,

Junyangdikul³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Extracted DNA was analyzed for mucosal high risk HPV-DNA and HPV genotypes (16,18,31,33,35,39,45, 51, 52, 56, 58, 59, 68, 73 and 82) by PCR optimized for DNA extracted from FFPE tissue, followed by bead-based hybridization (Luminex technology, Multimetrix, Progen, Heidelberg), as described previously. 17,18 HPV-DNA contamination protection steps (e.g., new microtome blades for every block, separated pre and post PCR areas) were applied and appropriate controls (tissue-free paraffin blocks, water-controls) were processed to monitor potential high risk HPV-DNA contamination.…”

Section: Hpv-dna Genotypingmentioning

confidence: 99%

CD56-positive lymphocyte infiltration in relation to human papillomavirus association and prognostic significance in oropharyngeal squamous cell carcinoma

et al. 2016

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Human papillomavirus (HPV)-related squamous cell carcinoma of the oropharynx (OSCC) are clinical and biological distinct from their HPV-unrelated counterparts. Patients with HPV-related OSCC display improved prognosis and therefore we investigated possible immune cell infiltrations associated with this tumor phenotype. We retrospectively analyzed a randomly selected cohort of 140 OSCC for presence of immune cells and HPV by immunohistochemistry and PCR followed by beadbased hybridization (Luminex technology). HPV prevalence was 24.3% as determined by positive staining of p16INK4a and detection of high risk HPV-DNA. We found significantly higher numbers of CD56 positive (CD561) cells in tumor and surrounding microenvironment in HPV-associated compared to HPV-negative OSCC (t-test: p 5 0.004 and p 5 0.002). For the entire cohort presence of CD561 cells was associated with increased overall survival independent from HPV (Kaplan-Meier: p 5 0.002; Cox regression: p 5 0.042). Presence of CD561 cells also correlated with a better outcome in HPV-negative and especially in HPV-negative OSCC with alcohol consumption 2 standard drinks per day (Kaplan-Meier: p 5 0.05 and p 5 0.003). Immunofluorescence localization of granular Granzyme B (GZMB) within CD561 cells and coexpression of CD16 and CD56 suggests that detected CD561 cells mainly represent cytotoxic Natural Killer (NK) cells. The fraction of potentially cytotoxic NK cells was significantly higher in HPV-associated compared to HPV-negative OSCC (Mann-Whitney-U-Test: p 5 0.011). The elevated abundance and activity of cytotoxic NK cells in OSCC with HPV driven carcinogenesis might contribute to favorable outcome in HPV-related OSCC.Head and neck cancer (HNC, comprising cancers of the oral cavity, lip, pharynx, nasopharynx and larynx) is ranking at position seven of newly diagnosed cancers and cause of cancer death worldwide, with 4.8% of total cancer incidence and 4.6% of total cancer mortality. 1 In particular oropharyngeal squamous cell carcinomas (OSCC) are related to high risk human papillomavirus (HPV) infection, which is accepted to be causally connected to HNC. 2,3 A recently published metaanalysis demonstrates a rising incidence of HPV1 OSCC in the United States from 21% (pre-1990), to 51% (1990-1999), to 65% (2000-2013). 4 Patients with HPV-associated OSCC show lower levels of disease recurrence and progression compared to patients with HPV-negative OSCC. Even with good loco regional tumor control, patients with HPV-associated OSCC have similar rates of distant metastases as patients with HPVnegative OSCC. Further efforts are needed to understand clinical and biological features of this distinct disease. 2,5,6 Molecular basis of HPV-associated cancers differ from their HPVunrelated counterparts. 3 Pathways related to cell cycle control or apoptosis (commonly affected by mutations in HPVnegative cancers) are silenced at protein level by HPVoncoproteins (mainly E6 and E7). It has been speculated that lower levels of genetic alterations contribute to better treat...

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“…Fewer studies have addressed the association of HPV in laryngeal cancer [113,116,117]. Kreimer reviewed 35 PCR-based studies on 1,435 patients with laryngeal SCC and determined the cumulative pooled prevalence for HPV to be 24.0 %, (95 % CI 21.8, 26.3) [113].…”

Section: Hpv and Laryngeal Cancermentioning

confidence: 99%

Human Papillomavirus in Non-Oropharyngeal Head and Neck Cancers: A Systematic Literature Review

Isayeva

Maswahu

et al. 2012

Head and Neck Pathol

228

218

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Perhaps one of the most important developments in head and neck oncology of the past decade is the demonstration that patients with human papillomavirus (HPV)-mediated oropharyngeal cancers have significantly improved outcomes, compared to HPV-negative counterpart patients. This has become the basis for clinical trials investigating the impact on ''treatment deintensification'' for patients with HPV-mediated oropharyngeal cancers. Unfortunately, the significance of HPV in non-oropharyngeal head and neck cancers is much less certain. Our goal is to systematically review the published data regarding the role HPV in carcinomas of the oral cavity, larynx, sinonasal tract and nasopharynx with respect to HPV detection frequency, viral activity, and association with outcome. We also present preliminary data on HPV16/18 transcriptional status in oral cavity carcinomas, as well as salivary gland neoplasia, as determined by nested reverse transcription PCR for HPV E6/E7 RNA. The weighted prevalence (WP) of HPV DNA detection in 4,195 oral cavity cancer patients is 20.2 %, (95 % CI 16.0 %, 25.2 %). HPV16 is the most common type detected. Importantly, no data currently demonstrates a significant association between the presence of HPV DNA and improved outcome. The WP of HPV DNA in 1,712 laryngeal cancer patients is 23.6 %, (95 % CI 18.7 %, 29.3 %). Similarly, no association has yet been demonstrated between HPV DNA status and outcome. The WP of HPV DNA detection in 120 sinonasal cancer patients is 29.6 % (95 % CI 17.8 %, 44.9 %), and in 154 nasopharyngeal carcinoma patients is 31.1 %, (95 % CI 20.3 %, 44.5 %). Recent preliminary data also suggests an association between HPV and certain salivary gland neoplasms. The clinical significance of these findings is unclear. The published data strongly support the need for studies on patients with oral and laryngeal carcinomas that will be powered to find any differences in clinical outcome with respect to HR-HPV and p16 overexpression.

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Human papillomavirus and head and neck cancer: a systematic review and meta‐analysis

Cited by 328 publications

References 32 publications

Whole Genome Analysis of Human Papillomavirus Genotype 11 from Cervix, Larynx and Lung

Whole Genome Analysis of Human Papillomavirus Genotype 11 from Cervix, Larynx and Lung

CD56-positive lymphocyte infiltration in relation to human papillomavirus association and prognostic significance in oropharyngeal squamous cell carcinoma

Human Papillomavirus in Non-Oropharyngeal Head and Neck Cancers: A Systematic Literature Review

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