Human papillomavirus and oral squamous cell carcinoma: A review of HPV-positive oral squamous cell carcinoma and possible strategies for future

Jiang, Shan; Dong, Yong

doi:10.1016/j.currproblcancer.2017.02.006

Cited by 89 publications

(71 citation statements)

References 16 publications

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“…The prevalence of human papillomavirus (HPV) infection could be contributing to the growing number of cases of HPV-positive oral squamous cell carcinoma. Oral HPV infection can be transmitted between people, with oral sex and open-mouthed kissing as probable routes for oral HPV infection 42 . Thus, a core group of modifiable risk factors is common to many chronic diseases and oral diseases (Figure 2) 43,44 .…”

Section: Common Risk Factorsmentioning

confidence: 99%

Surveillance and monitoring of oral health in elderly people

Miyazaki

Jones

Beltrán-Aguilar

2017

International Dental Journal

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Continued ageing of the global population is expected to pose significant challenges to maintaining optimum lifelong health in individuals and populations. Oral health is an essential element of general health and quality of life throughout an individual's life course, yet it is often neglected in integrated approaches to general health promotion. Surveillance and monitoring systems are essential for developing oral health policy and strategy at both national and community levels. As major oral diseases, dental caries and periodontal diseases are core indicators for surveillance at every stage of life. In addition, oral mucosal lesions and masticatory function are essential indicators, especially in an ageing population. The assessment of risk factors such as tobacco use, alcohol consumption or dietary habits (e.g., sugar intake) is also important for oral disease prevention. Although surveillance is conducted through clinical examinations (normative assessments), this method is becoming more difficult to use because of high costs and human resource shortages, even in high‐income countries. Alternative and less resource‐demanding approaches, such as self‐reported protocols, are therefore needed at the global level. The World Health Organization's (WHO) oral health surveillance and monitoring activities have evolved into the Oral Health STEPwise approach, which includes questionnaire surveys (Step 1) and clinical examinations (Step 2). Collaboration between international organisations such as the World Dental Federation (FDI), WHO and the International Association for Dental Research (IADR) is now needed to coordinate global oral health surveillance and monitoring systems.

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Section: Common Risk Factorsmentioning

confidence: 99%

Surveillance and monitoring of oral health in elderly people

Miyazaki

Jones

Beltrán-Aguilar

2017

International Dental Journal

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“…However, the role of HPV vaccine in the prevention of oral HPV infection remains to be further investigated. It is still unclear whether the vaccine has effects on oral HPV infection [1]. There is also a lack of research on this topic.…”

mentioning

confidence: 99%

“…This fact has reinforced the necessity for research into clarification of the relationship among oral HPV infection, HPV-positive OSCC, and HPV vaccines. This article makes this question clearer and discusses possible strategies, considering that the association between HPV vaccine and HPV-positive OSCC is confirmed [1].The most effective protective measure for HPV infection is the HPV vaccine [3]. However, people's participation in HPV vaccination programs is significantly lower than for other vaccines.…”

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confidence: 99%

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A promising measure to prevent HPV-positive oral squamous cell carcinoma

Zhang¹,

Jiang²,

Zang³

2017

Infection International

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The article "HPV and oral squamous cell carcinoma: a review of HPV-positive OSCC and possible strategies for future" provides inspiring insights into the association between human papillomavirus (HPV) infection and oral squamous cell carcinoma (OSCC), as well as the possible strategies that we can adopt in future to minimize its health impact on the population [1]. This association has been widely recognized in recent years, particularly, for the high-risk HPV 16 and 18 strains. The cancer-inducing proteins E6 and E7 of HPV have been identified to be the main factors that inhibit the tumor suppressors p53 and retinoblastoma protein (pRb), contributing to the development of OSCC. It also has been confirmed that HPV infection is associated with OSCC prognosis. Compared to HPV-negative OSCC patients, HPV-positive OSCC patients have a better prognosis [2].At present, there is no suitable OSCC HPV infection detection method approved by the health administration. Potential methods include immunohistochemical detection of p16 expression, polymerase chain reaction (PCR), or in situ hybridization detection method, which are used to indirectly reflect the HPV infection status. Due to the ineffectiveness of these methods, there are no HPV infection status screening programs for the OSCC high-risk group. Therefore, developing effective HPV detection methods for the early detection and treatment of HPV-induced OSCC is of great significance.HPV vaccine has been listed by the US Food and Drug Administration (FDA) for >10 years. We have witnessed the development of the HPV vaccine from the initial stage of protection against two HPV strains (HPV 16 and 18) to much wider protection against nine strains (HPV 6, 11, 16, 18, 31, 33, 45, 52, and 58). The coverage of pathogenic HPV has increased from 70% to 90%. HPV vaccines play an important role in the prevention of HPV infection in the reproductive tract. However, the role of HPV vaccine in the prevention of oral HPV infection remains to be further investigated. It is still unclear whether the vaccine has effects on oral HPV infection [1]. There is also a lack of research on this topic. Studies with large sample sizes and on both genders are needed for the confirmation of the protective effects.In the recent 10 years, the incidence of OSCC has increased. This fact has reinforced the necessity for research into clarification of the relationship among oral HPV infection, HPV-positive OSCC, and HPV vaccines. This article makes this question clearer and discusses possible strategies, considering that the association between HPV vaccine and HPV-positive OSCC is confirmed [1].The most effective protective measure for HPV infection is the HPV vaccine [3]. However, people's participation in HPV vaccination programs is significantly lower than for other vaccines. Based on statistics from the US, in 2015, the HPV vaccination participation rate was 41.9% and 28.1%, respectively, among girls and boys aged 13-17 years. These rates are much lower than the target set by the US, which expects an 8...

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A systematic review on the molecular and clinical association between Human Papillomavirus and Human Immunodeficiency Virus co‐infection in Head, Neck and Oral squamous cell carcinoma

Chakraborty

Ramasubbu

Banerjee

et al. 2023

Reviews in Medical Virology

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Head and neck cancer, one of the most commonly prevalent malignancies globally is a complex category of tumours that comprises cancers of the oral cavity, pharynx, and larynx. A specific subgroup of such cancers has been found with some unique chromosomal, therapeutic, and epidemiologic traits with the possibility of affecting via co‐infection. About 25% of all head and neck cancers in the population are human papillomavirus infection (HPV)‐associated, typically developing in the oropharynx, which comprises the tonsils. In the period of efficient combined antiviral treatment, HPV‐positive oral cancers are also becoming a significant contributor to illness and fatality for Human Immunodeficiency Virus (HIV)‐infected persons. Although the prevalence and historical background of oral HPV transmission are not thoroughly understood, it seems likely that oral HPV transmission is relatively frequent in HIV‐infected people when compared to the overall population. Therefore, there is a need to understand the mechanisms leading to this co‐infection, as there is very little research related to that. Hence, this study mainly focus on the therapeutical and biomedical analysis of HPV and HIV co‐infection in the above‐mentioned cancer, including oral squamous cell carcinoma.

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Human papillomavirus and oral squamous cell carcinoma: A review of HPV-positive oral squamous cell carcinoma and possible strategies for future

Cited by 89 publications

References 16 publications

Surveillance and monitoring of oral health in elderly people

Surveillance and monitoring of oral health in elderly people

A promising measure to prevent HPV-positive oral squamous cell carcinoma

A systematic review on the molecular and clinical association between Human Papillomavirus and Human Immunodeficiency Virus co‐infection in Head, Neck and Oral squamous cell carcinoma

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