Human papillomavirus detection and p16 methylation pattern in a case of esophageal papilloma

Afonso, Larissa Alves; Moysés, Natalia; Cavalcanti, Sílvia M. B.

doi:10.1590/s0100-879x2010007500055

Cited by 10 publications

(8 citation statements)

References 18 publications

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“…In our study, amongst the 38 SCPs analyzed, 7 (19%) were positive for HPV DNA (5 males and 2 females); 3 SCPs were of genotype 6, whereas 4 were of genotypes 16, 18, 31, and 81 that are known to have high oncogenic potential. Esophageal SCP with high oncogenic risk has been reported previously (15,16). In our study, one of the high oncogenic risk-containing papillomas presented 2 types of high-risk genotype within the same papilloma.…”

Section: Discussionsupporting

confidence: 61%

Analyzing esophageal squamous cell papillomas for the presence of human papilloma virus

Tıftıkcı

Kutsal²,

Altıok³

et al. 2017

Turk J Gastroenterol

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Background/Aims: Human Papilloma Virus (HPV) infection can be a predisposing condition for the development of squamous cell papilloma (SCP) of the esophagus, which can progress to dysplasia and to carcinoma as a result of chronic infection. The aim of the present study was to search for the presence of HPV in the esophageal SCP, and to genotype the detected HPV. Materials and Methods: Data from patients with definite diagnosis of SCP of the esophagus were identified from pathology records for two years period at different Hospitals. Slides from each patient were reviewed and samples with satisfactory papilloma tissues were submitted to molecular analysis. DNA has been isolated. DNA sequencing has been performed for genotyping HPV for all types. Results: Our study group consisted of 21 women and 17 men (a total of 38 patients), mean age was 41 years (range 17-67 years). Most of the papillomas were located at mid-esophagus (68%). Eight out of 38 patients (21%) had associated erosive esophagitis, and fourteen patients (36.8%) had Helicobacter Pylori (H. pylori). Of the 38 SCP analyzed, seven (19%) were positive for HPV DNA. Three of them were of genotype 6, whereas four were of genotype 16, 18, 31, 81 that are known as highly oncogenic. There were no correlations between the presence of HPV and the patient's age, the presence of reflux esophagitis or H. pylori, smoking habit and the location of the papillomas. Conclusion: The presence of high-risk type HPV in esophageal SCP may implicate a role of the virus in the pathogenesis of the esophageal tumor.

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Section: Discussionsupporting

confidence: 61%

Analyzing esophageal squamous cell papillomas for the presence of human papilloma virus

Tıftıkcı

Kutsal²,

Altıok³

et al. 2017

Turk J Gastroenterol

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“…High-risk HPV types demonstrate an integration tendency, as can be assumed in our study by the mRNA oncoproteins' expression. We should also mention, as many investigators indicate, that low-risk HPV types (HPV 6 in our case) have been found in some head and neck carcinomas and might be implicated in the carcinogenesis process [14, 18, 19]. …”

Section: Discussionmentioning

confidence: 64%

Prevalence of Human Papillomavirus in 45 Greek Patients with Oral Cancer

Kouvousi

Xesfyngi

Tsimplaki

et al. 2013

Journal of Oncology

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The relation between HPV and head and neck cancer has recently and extensively been investigated. The purpose of this study was to indentify HPV genotypes, as well as E6/E7 mRNA expression of high-risk HPVs (16, 18, 31, 33 and 45) in oral squamous cell carcinomas (OSCCs) from 45 Greek patients. The overall prevalence of HPV DNA positive OSCCs was 11.1% (5/45), while high-risk HPV DNA was found in 6.7% (3/45) of OSCCs. E6/E7 mRNA expression was detected in 8.9% (4/45) of the oral cavity samples. Our data indicated that HPV 16 was the commonest genotype identified in HPV-positive OSCCs by both DNA and RNA tests. This study confirms the prevalence of HPV infections among patients with OSCCs. Future analysis and followup of more OSCCs will enable us to correlate HPV detection and clinical outcome.

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“…A total of 39 studies were considered eligible for the present analysis , comprising 427 esophageal papillomas analyzed by different HPV detection methods. Included are both case reports and larger series, comprising up to 82 samples analyzed by PCR and 33 papillomas examined by ISH (Table ).…”

Section: Resultsmentioning

confidence: 99%

Detection of human papillomavirus in esophageal papillomas: systematic review and meta‐analysis

Syrjänen

2012

APMIS

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Since first suggested (in 1982), etiological role for human papillomavirus (HPV) in esophageal papillomas has aroused increasing interest. The objective of this study was to perform systematic review and formal meta-analysis of the literature reporting on HPV detection in esophageal squamous cell papillomas (ESCP). Literature was searched through May 2012. The effect size was calculated as event rates (95% CI), with homogeneity testing using Cochran's Q and I(2) statistics. Meta-regression was used to test the impact of study-level covariates (HPV detection method, geographic origin) on effect size, and potential publication bias was estimated using funnel plot symmetry. Thirty nine studies were eligible, covering 427 ESCPs from different geographic regions. Altogether, 132 (30.9%) cases tested HPV positive; effect size 0.375 (95% CI 0.319-0.434) using the fixed-effects (FE) model and 0.412 (95% CI 0.295-0.540) using the random-effects model. In meta-analysis stratified by (i) HPV detection technique and (ii) geographic study origin, the between-study heterogeneity was not significant (p = 0.071 and p = 0.105, respectively). In meta-regression, HPV detection method (p = 0.260) and geographic origin (p = 0.436) were not significant study-level covariates accounting for the heterogeneity in HPV prevalence. Some evidence for publication bias was found only for PCR-based studies, with a marginal impact on summary effect size estimates. In sensitivity analysis, all meta-analytic results were robust to all one-by-one study removals. In stratified meta-analysis and formal meta-regression, the variability in HPV detection rates in ESCPs is not explained by the HPV detection method or geographic origin of the study.

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Human papillomavirus detection and p16 methylation pattern in a case of esophageal papilloma

Cited by 10 publications

References 18 publications

Analyzing esophageal squamous cell papillomas for the presence of human papilloma virus

Analyzing esophageal squamous cell papillomas for the presence of human papilloma virus

Prevalence of Human Papillomavirus in 45 Greek Patients with Oral Cancer

Detection of human papillomavirus in esophageal papillomas: systematic review and meta‐analysis

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