Human papillomavirus DNA and P16<sup>INK4A</sup>expression in concurrent esophageal and gastric cardia cancers

Ding, Guang-Cheng; Ren, Jingli; Chang, Fu-Bao; Li, Jilin; Yuan, Ling; Song, Xin; Zhou, Shengli; Guo, Tao; Fan, Zong-Min; Zeng, Yi; Wang, Lidong

doi:10.3748/wjg.v16.i46.5901

Cited by 36 publications

(33 citation statements)

References 18 publications

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“…In addition, 15 studies provided the prevalence of HPV in different histological differentiations of patients with GC, which were divided into well-differentiated, moderately differentiated, poorly differentiated, and undifferentiated grades 16–30. Some studies provided concrete information about HPV prevalence in different clinical stages (TNM: I, II, III, and IV),16,19,27,31,32 the age and sex15,16,18,19,25,27,32 of the patients, and specific HPV types (HPV16 and HPV18) 15,16,20–24,29–31,33–39Table 1 provides the information about the studies.…”

Section: Resultsmentioning

confidence: 99%

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Human papillomavirus as a potential risk factor for gastric cancer: a meta-analysis of 1,917 cases

Zeng¹,

Luo²,

Zou³

et al. 2016

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BackgroundHuman papillomaviruses (HPVs) are causally associated with the tumorigenesis of several classes of cancers. However, the prevalence of HPV in gastric cancer (GC) has not yet been systematically reviewed. Hence, a meta-analysis was conducted to estimate the HPV prevalence in patients with GC, and its potential etiologic significance was assessed.MethodsThe pooled HPV prevalence and 95% confidence intervals (CIs) were estimated among all GC patients. Heterogeneity was described by using the I2 statistic. Sources of heterogeneity were explored by meta-regression and stratified analyses. The meta-influence was applied to evaluate the influence of a single study on the pooled estimates. Odds ratios (ORs) and 95% CIs were computed for case–control studies. For research providing clinicopathological parameters of age, sex, pathological, differentiated, and clinical stages, and HPV subtypes, the corresponding pooled ORs and 95% CIs were also calculated.ResultsThirty studies were included in the current meta-analysis, involving 1,917 patients with GC and 576 controls. The pooled HPV prevalence was 28.0% (95% CI: 23.2%, 32.7%) among all the patients with GC, and the I2 was 96.9% (P<0.001). A pooled OR of 7.388 (95% CI: 3.876, 14.082) was achieved based on 15 case–control studies (I2=56.7%, P=0.004). Moreover, the HPV prevalence was significantly higher in patients from China than in those from non-Chinese regions (31% vs 9%, I2=95.0%, P<0.001). The pooled prevalence of HPV16 was 21% in GC tissues, and the pooled prevalence of HPV18 was 7% with an OR of 3.314 (95% CI =1.617, 6.792). HPV16 was 3 times more frequently detected than HPV18.ConclusionHPV could play a potential role in the pathogenesis of GC. A causal relationship can be confirmed only by detecting HPV in the cells of GC precursor lesions (gastric dysplasia or adenoma). In addition, this study might be beneficial for expounding the potential etiologic significance of molecular mechanism of gastric tumorigenesis and providing opinions regarding precautionary measures.

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Section: Resultsmentioning

confidence: 99%

“…Information on age and sex was collected from 6 studies 16,18,19,25,27,32. HPV was positive in 75 of the 223 patients with GC aged >50 years, whereas it was positive in 45 of the 106 patients with GC aged <50 years.…”

Section: Resultsmentioning

confidence: 99%

Human papillomavirus as a potential risk factor for gastric cancer: a meta-analysis of 1,917 cases

Zeng¹,

Luo²,

Zou³

et al. 2016

OTT

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“…HPV is known to have a strong association with esophageal squamous cell carcinoma, 47 but its role in the development of EAC is much less clear. Outside of the esophagus, HPV has an established role in the development of cancers of the cervix 48 and oropharynx.…”

Section: Roles Of Virusesmentioning

confidence: 99%

Microbiome, Innate Immunity, and Esophageal Adenocarcinoma

Baghdadi

Chaudhary

Pei

et al. 2014

Clinics in Laboratory Medicine

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With the development of culture-independent technique, a complex microbiome has been established and described in the distal esophagus. Over recent decades, the incidence of esophageal adenocarcinoma (EAC)—a relatively rare cancer with high mortality—has increased dramatically in the United States. Several studies documenting an altered microbiome associated with EAC and its precedents (i.e., Barrett’s esophagus and reflux esophagitis) suggest that dysbiosis may be contributing to carcinogenesis, potentially mediated by interactions with toll-like receptors. Investigations attempting to associate viruses, in particular human papilloma virus, with EAC have not been as consistent. Regardless, currently available data is cross-sectional and therefore cannot prove causal relationships. Prospectively, microbiome studies open a new avenue to the understanding of the etiology and pathogenesis of reflux disorders and EAC.

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“…Thus, to improve the early diagnosis of GCA, it is important to investigate the molecular mechanisms underlying the development and progression of GCA and to identify possible biomarkers. A number of studies have analyzed the expression of MK or syndecan-1 in distal gastric adenocarcinoma; however, few studies have explored this in GCA (18)(19)(20). Human MK can bind syndecan proteoglycan family members, receptor-type tyrosine kinase-ζ, low-density lipoprotein, receptor-related protein and ALK.…”

Section: A B a Bmentioning

confidence: 99%

Midkine and syndecan-1 levels correlate with the progression of malignant gastric cardiac adenocarcinoma

Yao

Gao

et al. 2014

Molecular Medicine Reports

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Abstract. The present study aimed to determine whether the expression levels of midkine (MK) and syndecan-1 correlate with the malignant progression and poor prognosis of gastric cardiac adenocarcinoma (GCA). GCA tissue samples (n=72) were obtained from the Department of Pathology of the First Affiliated Hospital of Henan University of Science and Technology (Luoyang, China). The paraffin-embedded samples had been surgically resected and pathologically diagnosed between 2007 and 2009. Normal gastric cardiac biopsy specimens (n=40) were also collected as the control. The expression levels of MK and syndecan-1 were assessed by immunohistochemistry using the high-sensitivity streptavidin-peroxidase method. Statistical analysis was performed on the data obtained using the SPSS 17.0 statistics package. MK expression was detected in 76.4% of GCA samples and 5% of normal gastric cardiac mucosa specimens. A significant positive correlation was observed between the expression levels of MK and the infiltrative depth of the tumor, the presence of lymph node metastasis and the prognosis of the patients (P<0.05). Syndecan-1 expression was detected in 38.9% of GCA samples and 100% of normal gastric cardiac mucosa samples. The expression levels of syndecan-1 were negatively correlated with the grade of differentiation, serosal membrane invasion, lymph node metastasis and the patient's prognosis (P<0.05). Notably, the expression levels of MK and syndecan-1 were inversely correlated (r=-0.352, P<0.01) in the GCA tissue samples. These results suggest that high expression levels of MK in GCA tissues may indicate a differentiation stage that is characteristic of malignancy, a late clinical stage and a poor prognosis, whereas increased syndecan-1 levels may indicate a high degree of differentiation, an early clinical stage and a favorable prognosis. MK and syndecan-1 may serve as important biomarkers for monitoring the development and progression of GCA.

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Human papillomavirus DNA and P16^INK4Aexpression in concurrent esophageal and gastric cardia cancers

Abstract: HPV16 as a correlated risk factor may play an important role in the development of ESCC and GCA. P16(INK4A) may be a screening index in the HPV-associated carcinoma of gastric cardia.

Cited by 36 publications

References 18 publications

Human papillomavirus as a potential risk factor for gastric cancer: a meta-analysis of 1,917 cases

Human papillomavirus as a potential risk factor for gastric cancer: a meta-analysis of 1,917 cases

Microbiome, Innate Immunity, and Esophageal Adenocarcinoma

Midkine and syndecan-1 levels correlate with the progression of malignant gastric cardiac adenocarcinoma

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Human papillomavirus DNA and P16INK4Aexpression in concurrent esophageal and gastric cardia cancers

Abstract: HPV16 as a correlated risk factor may play an important role in the development of ESCC and GCA. P16(INK4A) may be a screening index in the HPV-associated carcinoma of gastric cardia.

Cited by 36 publications

References 18 publications

Human papillomavirus as a potential risk factor for gastric cancer: a meta-analysis of 1,917 cases

Human papillomavirus as a potential risk factor for gastric cancer: a meta-analysis of 1,917 cases

Microbiome, Innate Immunity, and Esophageal Adenocarcinoma

Midkine and syndecan-1 levels correlate with the progression of malignant gastric cardiac adenocarcinoma

Contact Info

Product

Resources

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Human papillomavirus DNA and P16^INK4Aexpression in concurrent esophageal and gastric cardia cancers