Human Papillomavirus DNA Is Found in the Vas Deferens

Rintala, Marjut; Pöllänen, Pasi; Nikkanen, V.; Grénman, Seija; Syrjänen, Stina

doi:10.1086/340421

Cited by 66 publications

(58 citation statements)

References 13 publications

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“…DNA from HPV 16, 18, 31 and 45 have been associated with invasive squamous cell cancers of the genital tract and anus (66,67). HPV is primarily transmitted through direct epithelial contact (62), but high risk HPV types have been detected in both semen and spermatozoa (68)(69)(70)(71), as well as in the vas deferens (72). In the current report, 3 out of the 8 cases that tested positive for generic HPV DNA were subtyped as HPV-16 (the other 5 cases were indeterminate).…”

Section: Discussionmentioning

confidence: 60%

Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia

Bezold

Politch

Kiviat

et al. 2007

Fertility and Sterility

218

167

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Objective-To determine the prevalence of pathogens that cause sexually transmitted infections (STIs) in semen from asymptomatic male infertility patients with and without leukocytospermia (LCS), and associations between STIs, inflammatory markers and other semen variables.Design-Retrospective, controlled study. Results-STI DNA was detected in 45/241 (18.7%) of the samples (CMV 8.7%, HPV 4.5%, HHV-6 3.7%, HSV 3.7%, CT 2.5%, EBV 0.4%, and HBV 0%), with no difference in prevalence between LCS and non-LCS groups. STI DNA in semen was associated with a decrease in sperm concentration, motile sperm concentration, total sperm count and neutral α-glucosidase concentration, whereas LCS was associated with a decrease in total sperm count, % normal forms and fructose concentration. Setting-CenterReprint requests: Deborah J. Anderson, Ph.D., Department of Obstetrics and Gynecology, Boston University School of Medicine, 670 Albany Street, Suite 516, Boston, MA 02118, (FAX: 617-414-8481; e-mail: E-mail: deborah.anderson@bmc.org). Capsule: Sexually transmissible pathogens were detected in 19% of semen samples from infertility patients seeking routine semen analyses; their presence was not associated with leukocytospermia, but was associated with reduced semen quality.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conclusion(s)-STI pathogen DNA was detected in semen from a high percentage of asymptomatic male infertility patients and was associated with poor semen quality. Efforts to diagnose and treat subclinical genital tract infections should be intensified. NIH Public Access

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Section: Discussionmentioning

confidence: 60%

Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia

Bezold

Politch

Kiviat

et al. 2007

Fertility and Sterility

218

167

View full text Add to dashboard Cite

show abstract

“…Table 3. Prevalence of type-specific HPV infection by anatomic site or specimen, HPV Detection in Men study (N = 463) Infection at any site (n = 463) Penile shaft (n = 449) Glans/corona (n = 444) Scrotum (n = 441) Perianal area (n = 436) Anal canal (n = 386) Urethra (n = 278) Semen (n = 337) 8,11,[17][18][19]. However, lack of comparability of sampling sites included in these studies and in others wherein samples were pooled from different anatomic sites makes direct comparison difficult.…”

Section: Discussionmentioning

confidence: 99%

“…8,9,[11][12][13][14][15][16][17][18][19][20]. Consistently, the prepuce has the highest proportion of HPV-positive samples.…”

Section: Introductionmentioning

confidence: 95%

Human Papillomavirus Prevalence and Type Distribution in Male Anogenital Sites and Semen

Nielson¹,

Flores

Harris³

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

147

143

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Background: Human papillomavirus (HPV) is sexually transmitted and causes cervical cancer. Although HPV can infect men and women, little is known about infection in men. Specifically, the prevalence of type-specific HPV infection and the distribution of infections by anogenital anatomic site in men are incompletely characterized. Methods: We tested 463 men ages 18 to 40 years for HPV at the glans/corona, penile shaft, scrotum, urethra, perianal area, anal canal, and in a semen sample. Eligible men acknowledged no history of genital warts and had sexual intercourse with a woman within the past year. HPV testing by PCR and reverse line blot genotyping for 37 types was conducted on each of the specimens from the seven sampling sites. Results: When HPV results from any sampling site were considered, 237 (51.2%) men were positive for at least one oncogenic or nononcogenic HPV type, and another 66 (14.3%)

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“…However, HPV reservoirs may exist in men's genitalia, mostly in intraurethral epithelia (6,15), and in the vas deferens (17). A possible vehicle of HPV transmission from father to infant is the sperm, via fertilization.…”

mentioning

confidence: 99%

Transmission of High-Risk Human Papillomavirus (HPV) between Parents and Infant: a Prospective Study of HPV in Families in Finland

Rintala¹,

Grénman²,

et al. 2005

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The Finnish HPV Family Study is a prospective cohort study assessing the dynamics of human papillomavirus (HPV) transmission between parents and infant. Serial genital and oral scrapings from 76 families, including mother, father, and infant, and semen samples were collected over 2 years of follow-up, analyzed by nested PCR, and confirmed by hybridization with 12 high-risk (HR) HPV types. The most common HPV profile was HR HPV in all family members (29%), followed by HPV-positive mother-infant pairs (26%). HPV-positive father-infant pairs were less frequent (11%), and in six (8%) families, only the infant was HR HPV positive. The prevalence of genital HR HPV in the parents ranged from 13 to 25%, and that of oral HPV ranged from 8 to 34%. In the infants, HPV DNA was detected in 15% of the genital and 10% of the oral samples at birth, reaching peaks of 18 and 21%, respectively, at 6 months, and declining to 10% at 24 months. Persistent HPV in the mother was a risk factor for oral HPV in the infant (odds ratio [OR], 5.69; 95% confidence interval [95% CI], 1.5 to 21.3), while oral HPV in the mother at 6 months was a risk factor for genital HR HPV (OR, 6.38; 95% CI, 1.15 to 35.32). No such independent risk could be attributed to subclinical HPV in the father. Persistent maternal cervical HPV and subclinical oral HPV affect the risk of infant HPV. The age of 6 months is a critical point for the infant to acquire or be free of HR HPV DNA.

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Human Papillomavirus DNA Is Found in the Vas Deferens

Cited by 66 publications

References 13 publications

Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia

Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia

Human Papillomavirus Prevalence and Type Distribution in Male Anogenital Sites and Semen

Transmission of High-Risk Human Papillomavirus (HPV) between Parents and Infant: a Prospective Study of HPV in Families in Finland

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