Human Papillomavirus E6 biosensing: Current progression on early detection strategies for cervical Cancer

HPV E6 Protein Associated SOX21-AS1 Promotes YAP/TAZ Activation by Attenuating YAP1 Ubiquitination in Human Cervical Cancer

“…Similar results were also reported by other research groups [12]. The E6 protein is an essential nuclear and cytoplasmic protein of about 18 kDa [4]. It contains four cysteine arrays that constitute two relatively large zinc fingers, both of which are required for full function: 1. a transcriptional trans-activator, or coactivator [4]; 2.…”

“…The E6 protein is an essential nuclear and cytoplasmic protein of about 18 kDa [4]. It contains four cysteine arrays that constitute two relatively large zinc fingers, both of which are required for full function: 1. a transcriptional trans-activator, or coactivator [4]; 2. E6 modulates normal cellular processes by binding to cellular proteins, in particular, E6AP and E6BP [24]; 3.…”

“…Oncoproteins E6 and E7 of high-risk HPV have proved to contribute to carcinogenesis by intervening cellular biological processes, especially by targeting the tumor suppressors including p53 and pRb [4,5]. For example, E6 protein can attenuate p53 function by degradation through combination with E6-associated protein (E6AP) [6], or by suppression CBP-p300, a p53 coactivator [7].…”

Effect of Nursing Guideline about Genital Human Papilloma Virus Infection on Knowledge and attitude of Female University Students

“…Human papilloma virus infection (HPV), diagnosed through, Pap smear, cytology screening and HPV test. All HPV screening tests right now are being used depending on the identification of viral nucleic acids based on the fact that HPV can't be cultured (11) . The successful management of HPV infectionfocused on medical therapy and surgical therapy (2) .…”

An Enhanced Ensemble Diagnosis of Cervical Cancer: A Pursuit of Machine Intelligence Towards Sustainable Health

“…Cervical cancer is one of the most common types of cancer in women, mostly caused by HPV (Human Papilloma Virus). Several studies have shown that early detection of cervical cancer can significantly impact patients' treatment and recovery [4], [5]. Commonly used techniques for the detection of cervical cancer include Pap smear (Papanicolaou test) [6], HPV DNA genotyping [7], HCII (Hybrid Capture II), hybrid capture [8], [9] and Southern blot hybridization assay [10].…”