Human Papillomavirus Genotype Prevalence in Invasive Penile Cancers from a Registry-Based United States Population

Hernandez, Brenda Y.; Goodman, Marc T.; Unger, Elizabeth R.; Steinau, Martin; Powers, Amy; Lynch, Charles F.; Cozen, Wendy; Saber, Maria Sibug; Peters, Edward S.; Wilkinson, Edward J.; Copeland, Glenn; Hopenhayn, Claudia; Huang, Youjie; Watson, Meg; Altekruse, Sean F.; Lyu, Cancan; Saraiya, Mona

doi:10.3389/fonc.2014.00009

Cited by 48 publications

(34 citation statements)

References 35 publications

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“…Men aged 45–70 years in all three countries continued to develop condyloma during follow‐up highlighting that men remain susceptible to acquiring new HPV‐related EGLs throughout their lives. HPV types 6 and 11 were the most common types to progress to condyloma and HPV types 16, 6 and 11 were the most common types to progress to PeIN, consistent with previous literature …”

Section: Discussionsupporting

confidence: 91%

“…HPV types 6 and 11 were the most common types to progress to condyloma and HPV types 16, 6 and 11 were the most common types to progress to PeIN, consistent with previous literature. 12,[26][27][28] The condyloma incidence rate was highest among men from the U.S. (1.90 per 100 person-years [p-y]) compared to men from Brazil (1.57 per 100 p-y) and Mexico (1.77 per 100 p-y), although the differences were not statistically significant. Condyloma incidence in the HIM Study was comparable to the placebo arm of the male quadrivalent HPV vaccine trial (IR 5 1.58 per 100 p-y) 29 and higher than incidence among men in England (IR 5 0.17 per 100 p-y), 30 Spain (IR 5 0.14 per 100 p-y) 31 and Germany (IR 5 0.18 per 100 py), 32 based on healthcare databases.…”

Section: Discussionmentioning

confidence: 99%

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Country‐specific HPV‐related genital disease among men residing in Brazil, Mexico and The United States: The HIM study

Sudenga

Torres

Fulp

et al. 2016

Intl Journal of Cancer

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The purpose of this study was to assess whether the incidence of histopathologically confirmed condyloma and penile intraepithelial neoplasia (PeIN) and rates of genital HPV infection progression to these lesions differs by country (Brazil, Mexico, and the U.S.). At each visit, lesions were biopsied and were categorized by pathologic diagnoses. The Linear Array genotyping method was used to identify HPV genotypes from genital swabs, while the INNO-LiPA HPV Genotyping Extra method was used for tissue specimens. Age-specific analyses were conducted for lesion incidence by country, with Kaplan–Meier estimation of cumulative incidence. The proportion of HPV infections that progressed to condyloma and PeIN, the median time to lesion development, and the incidence rates were estimated by country. When comparing demographic and sexual characteristics across the three countries, sexual orientation (p=0.008) and lifetime number of female sexual partners (p < 0.0001) were differentially associated with lesion incidence in the three countries. Condyloma incidence in Brazil and the U.S. decreased with age, while incidence remained constant across the lifespan in Mexico. There were no differences by country and age for PeIN incidence. HPV types 6 and 11 were the most common types to progress to condyloma, and HPV types 16, 6, and 11 were the most common types to progress to PeIN in all three countries. The continuous risk of condyloma and PeIN across all age groups and countries in this study emphasizes the need to ensure that strong HPV immunity, such as that obtained through vaccination, is maintained across the lifespan of men.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Country‐specific HPV‐related genital disease among men residing in Brazil, Mexico and The United States: The HIM study

Sudenga

Torres

Fulp

et al. 2016

Intl Journal of Cancer

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“…[47][48][49] A registry used as a VTR is an especially valuable research resource for basic scientists who are studying specific signaling molecules. [47][48][49] A registry used as a VTR is an especially valuable research resource for basic scientists who are studying specific signaling molecules.…”

Section: Using the Population-based Cancer Registry As A Sample Framementioning

confidence: 99%

“…There are a number of examples where central cancer registries have served as VTRs. [47][48][49] A registry used as a VTR is an especially valuable research resource for basic scientists who are studying specific signaling molecules. Using the central cancer registry as a VTR makes it possible for basic science investigators to determine the activity levels of specific signaling molecules from a sample of cases that truly represent the underlying population and to explore how the expression of these proteins varies by factors such as age, sex, race, treatment, stage, and place.…”

Section: Using the Population-based Cancer Registry As A Sample Framementioning

confidence: 99%

Unlocking the potential of population‐based cancer registries

Tucker

Durbin

McDowell

et al. 2019

Cancer

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Population-based cancer registries have improved dramatically over the last 2 decades. These central cancer registries provide a critical framework that can elevate the science of cancer research. There have also been important technical and scientific advances that help to unlock the potential of population-based cancer registries. These advances include improvements in probabilistic record linkage, refinements in natural language processing, the ability to perform genomic sequencing on formalin-fixed, paraffinembedded (FFPE) tissue, and improvements in the ability to identify activity levels of many different signaling molecules in FFPE tissue. This article describes how central cancer registries can provide a population-based sample frame that will lead to studies with strong external validity, how central cancer registries can link with public and private health insurance claims to obtain complete treatment information, how central cancer registries can use informatics techniques to provide population-based rapid case ascertainment, how central cancer registries can serve as a population-based virtual tissue repository, and how population-based cancer registries are essential for guiding the implementation of evidence-based interventions and measuring changes in the cancer burden after the implementation of these interventions. Cancer 2019;125:3729-3737.

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“…Penile cancer is a rare disease in developed countries; however, it is more common in poor regions [12]. The human papillomavirus (HPV) infection has been described in 22.2 to 63% of penile carcinomas [13][14][15][16][17][18][19], being the HPV16 the predominant type. The large range of the HPV positivity among different studies may be due to sampling methods, HPV detection procedures, histopathological subtypes, and population cohorts [20].…”

Section: Introductionmentioning

confidence: 99%

Nuclear loss and cytoplasmic expression of androgen receptor in penile carcinomas: role as a driver event and as a prognosis factor

et al. 2018

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Androgen receptor (AR) is a member of the steroid and nuclear family receptor that acts as transcription factor. AR signaling plays pivotal role in the development and progression of prostate cancer. However, the role of AR in penile cancer (PeCa) is poorly explored. Our previous molecular studies unveiled frequent AR mRNA loss in PeCa, which was further predicted as a major driver alteration in this neoplasm. Herein, we assessed the AR protein expression in 59 usual PeCa tissues and 42 surrounding normal tissues (SNT) by immunohistochemistry using a tissue microarray. In a paired analysis, we found a total absence of nuclear AR expression in PeCa while 95.2% of SNT samples presented strong nuclear AR expression (P < 0.001). Interestingly, 17 of 42 PeCa presented weak or moderate cytoplasmic AR staining, contrasting with 5 of 42 SNT (P = 0.008). Increased levels of AR cytoplasmic expression were related with poor prognosis features including advanced clinical staging (P = 0.044), compromised surgical margins (P = 0.005), and pathological inguinal node status (P = 0.047). Furthermore, AR cytoplasmic expression was also related with shorter overall survival (P = 0.032). In conclusion, the frequent loss of nuclear AR protein levels suggests a potential function in PeCa development. Based on this result, the androgen deprivation therapy is not indicated for PeCa patients. In addition, the AR cytoplasmic expression found in a significant number of cases (40.5%) showed prognostic value and pathways activated by the non-genomic AR signaling may represent a promising therapeutic strategy.

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Human Papillomavirus Genotype Prevalence in Invasive Penile Cancers from a Registry-Based United States Population

Cited by 48 publications

References 35 publications

Country‐specific HPV‐related genital disease among men residing in Brazil, Mexico and The United States: The HIM study

Country‐specific HPV‐related genital disease among men residing in Brazil, Mexico and The United States: The HIM study

Unlocking the potential of population‐based cancer registries

Nuclear loss and cytoplasmic expression of androgen receptor in penile carcinomas: role as a driver event and as a prognosis factor

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