Human Papillomavirus Genotypes and Cervical Cancer in Northeast Thailand

Abstract

Human papillomavirus (HPV) is a major cause of cervical cancer. More than 100 HPV genotypes have been identified; however the distribution varies geographically and according to ethnicity. The purpose of this study was to investigate the prevalence and distribution of HPV subtypes among Northeast Thai women. Subjects included 198 cases of SCCA and 198 age-matched, healthy controls. HPV-DNA was amplified by PCR using the consensus primers GP5+/6+ system followed by reverse line blot hybridization genotyping. The prevalence of high-risk HPV infection was 21 (

Prevalence of High Risk Human Papillomavirus Infection with Different Cervical Cytological Features among Women Undergoing Health Examination at the National Cancer Institute, Thailand

“…In low incidence area of cervical cancer in Songkhla HPV infection was found 3.8%, while in high incidence area in Lampang HPV infection was found 8.0%. Earlier studies of cervical and vulvar lesions in Thailand demonstrated HPV-16 to be most prevalent (Natphopsuk et al, 2013;Ngamkham et nal., 2013;Swangvaree et al, 2013;Siriaunkgul et al, 2014).…”

HPV Detection and Genotyping in Vulvar Squamous Cell Carcinoma in Northern Thailand

“…The role of HPV as an etiologic factor of SCC in the other sites of anogenital tract has been increasingly recognized and genotype distribution has been assessed in cervical lesions in Thailand (Natphopsuk et al, 2013;Swangvaree et al, 2013). In vulvar carcinoma, the overall prevalence of HPV infection has been reported as 40.4%, which is lower than that of anal cancer in women (90.8%) and vaginal cancer (69.9%) (De Vuyst et al, 2009).…”

Human Papillomavirus Genotype Distribution among Thai Women with High-Grade Cervical Intraepithelial Lesions and Invasive Cervical Cancer: a Literature Review

“…The high prevalence of HR-HPV infection among Thai women with ICC also has been consistently reported across the regions ranging from 77% to 97% (Tungsinmunkong et al, 2006;Siriaunkgul et al, 2008;Siriaunkgul et al, 2011;Chinchai et al, 2012;Natphopsuk et al, 2013;Siriaunkgul et al, 2013;Aromseree et al, 2014). In addition, more than 60% of ICC was HPV 16 and/or 18-related supporting that the majority of ICC in all regions is associated with HPV16 and/or 18.…”

“…In addition, more than 60% of ICC was HPV 16 and/or 18-related supporting that the majority of ICC in all regions is associated with HPV16 and/or 18. Multiple HPV infection in Thai women varied widely from approximately 6% to 20% depending on histologic subtypes of ICC (Table 4) (Siriaunkgul et al, 2008;Siriaunkgul et al, 2011;Chinchai et al, 2012;Natphopsuk et al, 2013;Siriaunkgul et al, 2013).…”