Human papillomavirus genotypes in genital warts in Latin America: a cross-sectional study in Bogota, Colombia

Abstract

Epidemiological studies on benign lesions related to human papillomavirus (HPV) infection are scarce in Latin America. We enrolled 342 consecutive patients with lesions suspected of being genital warts (GW). All patients underwent confirmatory biopsy and GP5+/GP6+/- Reverse Line Blot HPV testing on frozen tissue. In 261 (81%) cases, the diagnosis was confirmed by histopathology and HPV was detected in 90.6% of men and 87.7% of women. HPV 6 was by far the most common type in both women (62%) and men (56%), followed by HPV 11 (∼20%). Co-infection with these two types occurred in 7% and 12% of women and men, respectively. HPV16 ranked third in prevalence, with 16% of patients testing positive. Twenty-five percent of cases tested positive for multiple HPV genotypes. Although HPV 6 and HPV 11 were the main types detected and no differences between men and women were observed, we found HPV 11 contributed more to GW aetiology compared with previous reports, showing a variability of HPV type distribution in GW across populations. This information is valuable baseline data in Latin America for future estimations of the burden of GW in men and women and shows the potential benefit obtainable by prophylactic vaccination against HPV types 6 and 11.

Comparison of the risk factors and HPV types in males with anogenital warts with and without involvement of the urethral meatus in western Iran

“…Low-risk HPV types were the most commonly detected HPV types (75.0% and 69.2% in the AGW groups with and without UM involvement, respectively). Although low-risk HPV types HPV6 and HPV11 were found to be the causative agents in approximately 90% of AGWs (21), in a study from Latin America, low-risk HPV6 was found in only 56% of men with AGWs (22), which is nearly consistent with our findings. These differences may be related to variations in sex, sexual behavior, taking samples from different areas, and the sensitivity and specificity of the HPV genotyping methods.…”

Human Papillomavirus Virus (HPV) Genotype- and Age-Specific Analyses of External Genital Lesions Among Men in the HPV Infection in Men (HIM) Study

“…Differences in collection and diagnosis of lesions may have also varied between countries and pathologists, although the clinical procedures and the pathology panel were designed to minimize discrepancies. While the HPV prevalence in condyloma, particularly of low-risk types 6 and 11, was found to be ≥90% in a number of previous studies [2,[16][17][18], differences may also be attributed to variations by sex, country (affecting circulating types), and DNA extraction and HPV genotyping methods. The data presented here are the first results from a large, prospective cohort of men with regard to development of EGLs by genotype and age, laying the groundwork for subsequent studies of other risk factors that may contribute to HPV-related lesion development among men.…”

Simultaneous Induction of Benign Condyloma and High-grade Anal Dysplasia Induced by Low-risk Human Papillomavirus Type 42

“…In a study of anal carcinomas worldwide, a HPV42 single infection has been found in one of 438 (0.2%) cases (10). HPV42 was originally isolated from a benign vulvar papilloma and has been found in 1-2% of condylomas in recent studies (11)(12)(13). We and others have recently detected HPV42 mono-infections in AIN-containing intra-anal condylomas of HIV-positive patients (4,14).…”