Human papillomavirus (HPV) 16 and the prognosis of head and neck cancer in a geographical region with a low prevalence of HPV infection

López, Rossana Verónica Mendoza; Levi, José Eduardo; Eluf-Neto, José; Koifman, Rosalina Jorge; Koifman, Sérgio; Curado, María Paula; Michaluart-Junior, Pedro; Figueiredo, David Livingstone Alves; Saggioro, Fabiano Pinto; Carvalho, Marcos Brasilino de; Kowalski, Luiz Paulo; Abrahão, Márcio; Góis-Filho, Francisco de; Tajara, Eloíza H.; Waterboer, Tim; Boffetta, Paolo; Brennan, Paul; Wünsch-Filho, Victor

doi:10.1007/s10552-014-0348-8

Cited by 76 publications

(82 citation statements)

References 25 publications

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“…A third Mexican report showed a frequency of 9.1%. 26 All reports used different methodologies and studied different populations. These factors may explain the different frequencies observed.…”

Section: Frequency Of Sexually Transmitted Infections In Mexicomentioning

confidence: 99%

Sexually transmitted pathogens, coinfections and risk factors in patients attending obstetrics and gynecology clinics in Jalisco, Mexico

Casillas-Vega

Morfín‐Otero

García

et al. 2016

SALUD PÚBLICA DE MÉXICO

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Objective. To determine the frequency of nine sexually transmitted pathogens, coinfections and risk factors in patients attending obstetrics and gynecology clinics in Jalisco, Mexico. Materials and methods. Samples from 662 patients attending obstetrics and gynecology clinics were analyzed. Treponema pallidum, HIV, and HCV were detected by serology. HPV was detected by Polimerase Chain Reaction (PCR), and its genotype was determined by Restriction Fragment Length Polymorphism (RFLP). Trichomonas vaginalis, HSV-1, HSV-2, Mycoplasma genitalium, Neisseria gonorrhoeae and T. pallidum were detected by multiplex PCR. Results. By serology, HIV frequency was 6.8%, T. pallidum was 2.26%, and HCV was 0.15%. By PCR, HPV frequency was 13.9%, (more frequent genotype was 16, 33.7%), followed by T. vaginalis (14.2%), HSV-1 (8.5%), M. genitalium (2,41%), N. gonorrhoeae (2.11%), HSV-2 (1.8%), and T. pallidum (1.05%). Patients

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Section: Frequency Of Sexually Transmitted Infections In Mexicomentioning

confidence: 99%

Sexually transmitted pathogens, coinfections and risk factors in patients attending obstetrics and gynecology clinics in Jalisco, Mexico

Casillas-Vega

Morfín‐Otero

García

et al. 2016

SALUD PÚBLICA DE MÉXICO

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“…3 The so-called HPV epidemic is most prominent in patients of Northern European and North American origin, whereas other areas of the world still see few HPVassociated tumors. [4][5][6] In studies that include an assessment of HPV status, a shift in the traditional risk factors is nearly universally noted: viral-associated tumors are seen in younger populations that have lymph node-positive oropharyngeal carcinomas and lower rates of smoking. 7 Having said this, most patients with HPV-associated oropharyngeal carcinoma are still men in their 50s who have a smoking history, and true nonsmokers constitute only a minority.…”

Section: Introductionmentioning

confidence: 99%

Genetic Landscape of Human Papillomavirus–Associated Head and Neck Cancer and Comparison to Tobacco-Related Tumors

Hayes

Waes

Seiwert

2015

JCO

124

111

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Head and neck cancer is the fifth most common cancer worldwide. It is often amenable to curative intent therapy when localized to the head and neck region, but it carries a poor prognosis when it is recurrent or metastatic. Therefore, initial treatment decisions are critical to improve patient survival. However, multimodality therapy used with curative intent is toxic. The balance between offering intensive versus tolerable and function-preserving therapy has been thrown into sharp relief with the recently described epidemic of human papillomavirus-associated head and neck squamous cell carcinomas characterized by improved clinical outcomes compared with smokingassociated head and neck tumors. Model systems and clinical trials have been slow to address the clinical questions that face the field to date. With this as a background, a host of translational studies have recently reported the somatic alterations in head and neck cancer and have highlighted the distinct genetic and biologic differences between viral and tobacco-associated tumors. This review seeks to summarize the main findings of studies, including The Cancer Genome Atlas, for the clinician scientist, with a goal of leveraging this new knowledge toward the betterment of patients with head and neck cancer.

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“…The Human papillomavirus (HPV) type 16 was recognize by the International Agency for Research on Cancer as the only type of HPV that is carcinogenic to organs other than the cervix uteri, such as oral cavity oropharynx, tonsil, vulva, vagina, penis and anus 26 . In comparison with HPV negative tumors, HPV positive oropharyngeal squamous cell carcinomas have been associated with a better prognosis 9,10,27 , lesser history of tobacco and alcohol use 28 , higher socioeconomic status 3 , younger age on diagnosis and been more common in men and whites 17 among the world. In Brazil, the HPV 16 positive in tumor tissue was higher in women and patients with 50 years old or younger 27 .…”

Section: Discussionmentioning

confidence: 99%

“…In comparison with HPV negative tumors, HPV positive oropharyngeal squamous cell carcinomas have been associated with a better prognosis 9,10,27 , lesser history of tobacco and alcohol use 28 , higher socioeconomic status 3 , younger age on diagnosis and been more common in men and whites 17 among the world. In Brazil, the HPV 16 positive in tumor tissue was higher in women and patients with 50 years old or younger 27 . Sexual behavior is the most studied risk factor for the development of this tumor, but there is no concordance about which kind of sexual behavior is risky.…”

Section: Discussionmentioning

confidence: 99%

HPV positive oropharyngeal cancer: risky sexual behavior

Oliveira

Santos

Hojaij

2018

Rev. Med. (São Paulo)

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Rev Med (São Paulo ABSTRACT: Oropharyngeal squamous cell carcinomas have traditionally been associated with tobacco and alcohol use. Although smoking rates had been decreasing, there is an increase in the incidence of Oropharyngeal squamous cell carcinomas in the last years. This increase of Oropharyngeal squamous cell carcinomas is noticed in one specific type, Oropharyngeal squamous cell carcinomas associated with human papillomavirus (HPV) infection, mainly the HPV16 type, a high-risk HPV. Transmission of HPV is known as occur through sexual contact but many researches differ on which kind of sexual contact is the responsible for the HPV infection. Objective: The objective of this review is to verify in the literature if there is a pattern of sexual behavior that is more related with oropharyngeal squamous cell carcinoma HPV positive. The habits most associated with Oropharyngeal squamous cell carcinomas are oral sex and multiples sexual partners. The occurrence of this habits in the population varies from local culture, social status and ethnic group. In this context, health care professionals have a major responsibility in orientating about aspects of the disease, risk factors, vaccination and prognosis. Further researches are necessary to clarify the role of vaccination for HPV in future changes in the Oropharyngeal squamous cell carcinomas prevalence.Keywords: Oropharyngeal cancer; Papillomaviridae; Sexual behavior; Carcionma, squamous cell. RESUMO:O carcinoma de células escamosas de orofaringe é tradicionamente associado com uso de tabaco e álcool. Apesar da prevalência de tabagistas ter diminuído, a prevalência de carcinoma de células escamosas de orofaringe vem aumentando. Esse aumento do carcinoma de células escamosas de orofaringe pode ser notado em um tipo específico, o associado com infecção pelo papilomavirus humano (HPV), principalmente o HPV 16, um subtipo de HPV de alto risco. A transmissão do HPV é conhecidamente por contato sexual, mas muitas pesquisas diferem quanto ao tipo de contato responsável pela infecção pelo HPV. Objetivo: O objetivo dessa revisão é verificar se existe na literatura um padrão de comportamento sexual que está mais relacionado com o câncer de orofaringe HPV positivo. Os hábitos mais associados com carcinoma de células escamosas de orofaringe são realização de sexo oral e múltiplos parceiros sexuais. A ocorrência desses hábitos na população variam conforme a cultura local, nível social e grupos étnicos. Nesse contexto, profissionais de saúde têm grande responsabilidade na orientação sobre aspectos da doença, fatores de risco, vacinação e prognósticos. Outras pesquisas ainda são necessárias para determinar qual é o papel da vacinação contra HPV em futuras mudanças na prevalência do carcinoma de células escamosas de orofaringe.Descritores: Neoplasias orofaríngeas; Papillomaviridae; Comportamento sexual; Carcinoma de células escamosas. 99Oliveira DC, et al. HPV positive oropharyngeal cancer: risky sexual behavior.

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Human papillomavirus (HPV) 16 and the prognosis of head and neck cancer in a geographical region with a low prevalence of HPV infection

Abstract: Oropharyngeal squamous cell carcinoma is less aggressive in the HPV16 E6/E7 positive serology patients. HPV16 E6/E7 antibody is a clinically sensible surrogate prognostic marker of oropharyngeal squamous cell carcinoma.

Cited by 76 publications

References 25 publications

Sexually transmitted pathogens, coinfections and risk factors in patients attending obstetrics and gynecology clinics in Jalisco, Mexico

Sexually transmitted pathogens, coinfections and risk factors in patients attending obstetrics and gynecology clinics in Jalisco, Mexico

Genetic Landscape of Human Papillomavirus–Associated Head and Neck Cancer and Comparison to Tobacco-Related Tumors

HPV positive oropharyngeal cancer: risky sexual behavior

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