Human papillomavirus (HPV) persistence and HPV 31 predict the risk of recurrence in high-grade vaginal intraepithelial neoplasia

Potential impact of introducing a nonavalent HPV vaccination

“…HPV testing was performed using the Clinical Array Technology HPV 2 assay (CLART; Genomica, Madrid, Spain), which combines highly specific and sensitive PCR with low‐density array technology. Details regarding HPV testing have been reported elsewhere …”

“…Growing evidence supports the safety profile of the new vaccine . Ideally, the widespread implementation of the 9vHPV‐V will dramatically reduce the prevalence of HPV‐related conditions …”

“…[10][11][12][13][14][15][16] Ideally, the widespread implementation of the 9vHPV-V will dramatically reduce the prevalence of HPV-related conditions. [17][18][19] Data regarding trends in the prevalence of HPV types are still scant current evidence is based on non-recently published data. Here, we sought to investigate trends in prevalence of HPV types to test the potential utility of HPV vaccinations in women.…”

Retrospective study of the influence of HPV persistence on outcomes among women with high‐risk HPV infections and negative cytology

“…HPV testing was performed using a previously reported method . Demographic details, HPV data, and data related to the treatment of precancerous and cancerous lesions were reviewed retrospectively; data were retrieved from a dedicated database at the study institution that was updated prospectively at regular intervals.…”

LASER treatment for women with high‐grade vaginal intraepithelial neoplasia: A propensity‐matched analysis on the efficacy of ablative versus excisional procedures

“…Treatments included: topical application of imiquimod or 5‐fluorouracil (5‐FU), as well as ablative and excisional procedures executed via conventional surgery, electrosurgery and carbon dioxide LASER . The risk of developing invasive vaginal cancer in those patients remains unclear, ranging between 2% and 12% in different series . Recently, a multi‐institutional Italian study reports that more than 10% of women initially diagnosed with high‐grade vaginal intraepithelial neoplasia are detected with occult invasive vaginal cancer at the time of excisional procedure, thus suggesting the need to achieve a histological diagnosis before proceeding to ablative or medical treatments .…”