Human Papillomavirus (HPV)-Related Carcinoma of the Oropharynx with Squamous Cell and Adenoid Cystic Carcinoma-Like Features: Report of a Case

Hodgson, Christina K; Bayon, Rodrigo; Jensen, Chris S.; Robinson, Robert A.; D, Anand Rajan K

doi:10.1007/s12105-020-01233-0

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…In the last WHO Classification of Head and Neck Tumours from 2017, HMSC was introduced, but was not considered as its own entity due to too few reported cases in the literature, variable histology with focal overlap with nonkeratinizing SCCs and unknown prognostic significance [ 35 ]. Due to a possible similar micromorphological overlap with a basaloid SCC, indicated here as well as in previous studies [ 28 ], the occurrence of this morphological pattern outside the sinonasal region [ 16 , 17 ] and unclear clinical significance [ 16 ], we suggest that the HMSC, before it is more thoroughly characterized, could possibly be considered a histological subgroup of basaloid SCC.…”

Section: Discussionsupporting

confidence: 78%

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Analysis of Human Papillomavirus (HPV) and Polyomaviruses (HPyVs) in Adenoid Cystic Carcinoma (AdCC) of the Head and Neck Region Reveals Three HPV-Positive Cases with Adenoid Cystic-like Features

Zupancic

Holzhauser

Cheng

et al. 2022

Viruses

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An aetiological role of human papillomavirus (HPV) and/or human polyomaviruses (HPyVs) has been proposed in adenoid cystic carcinoma (AdCC). Moreover, HPV-related multiphenotypic carcinoma (HMSC) was recently introduced as an emerging entity of the sinonasal region. Here, we primarily want to study the role of HPV/HPyV in a large AdCC cohort and, secondly, possibly identify and characterize HMSC. Tumour DNA from 68 patients initially diagnosed with AdCC between 2000 and 2012 was, therefore, tested for 27 HPV types and 10 HPyVs. HPV DNA-positive samples were micromorphologically re-evaluated, further stained for p16INK4a, S100, p63 and CD117 and tested for the presence of the MYB-NFIB fusion transcript. Notably, no samples were HPyV-positive, while one sinonasal and two tonsillar carcinomas were HPV- and p16-positive. After re-evaluating the micromorphology, immunohistochemistry and presence of fusion transcripts, all tumours had the same appearance and fitted within the diagnosis of HMSC, but in all these three cases, the morphology of the HMSC and basaloid squamous cell carcinoma was overlapping. We conclude that HPV and HPyV have no major role in AdCC. However, based on our data, we also suggest that HMSC should be considered as a basaloid variant of squamous cell carcinoma, and not its own entity, until better characterized.

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Section: Discussionsupporting

confidence: 78%

“…The most common HPV type detected so far in HMSC is HPV 33, but other high-risk HPV types have also been described. Initially, HMSC was first reported to occur exclusively in the sinonasal region, but a recent case report has suggested that HMSC-like tumours may also occur outside this specific region [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Human Papillomavirus (HPV) and Polyomaviruses (HPyVs) in Adenoid Cystic Carcinoma (AdCC) of the Head and Neck Region Reveals Three HPV-Positive Cases with Adenoid Cystic-like Features

Zupancic

Holzhauser

Cheng

et al. 2022

Viruses

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Diagnostic algorithm for challenging blue cell sinonasal carcinoma

Laforga¹,

Abdullah

2023

Pathology - Research and Practice

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Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma—An Even Broader Tumor Entity?

Zupancic

Näsman

2021

Viruses

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Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC) is a recently defined tumor subtype with apparent favorable clinical outcome despite aggressive histomorphology. However, in recent years, additional numbers of cases, with more variable features and at locations outside the sinonasal region, have complicated the definition of HMSC. Here, we have performed a systematic review of all cases described so far in order to accumulate more knowledge. We identified 127 articles published between 2013 and 2021, of which 21 presented unique cases. In total, 79 unique patient cases were identified and their clinical and micromorphological nature are herein summarized. In our opinion, better clinical follow-up data and a more detailed tumor characterization are preferably needed before HMSC can finally be justified as its own tumor entity.

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Human Papillomavirus (HPV)-Related Carcinoma of the Oropharynx with Squamous Cell and Adenoid Cystic Carcinoma-Like Features: Report of a Case

Cited by 3 publications

References 33 publications

Analysis of Human Papillomavirus (HPV) and Polyomaviruses (HPyVs) in Adenoid Cystic Carcinoma (AdCC) of the Head and Neck Region Reveals Three HPV-Positive Cases with Adenoid Cystic-like Features

Analysis of Human Papillomavirus (HPV) and Polyomaviruses (HPyVs) in Adenoid Cystic Carcinoma (AdCC) of the Head and Neck Region Reveals Three HPV-Positive Cases with Adenoid Cystic-like Features

Diagnostic algorithm for challenging blue cell sinonasal carcinoma

Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma—An Even Broader Tumor Entity?

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